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Nisha Philip

@nishaphilip.bsky.social

Malaria Transmission, fish and mountains University of Edinburgh https://biology.ed.ac.uk/philip

9 Posts157 Follower113 Folgt
SPPIRIT Network@sppirit-network.bsky.social · 10mo ago

📢 Just 1 month to go until our SPPIRIT ECR symposium 📝 Abstract deadline extended to 10 October 2025 - don’t miss out!

SPPIRIT Network@sppirit-network.bsky.social · 11mo ago

📢 7 weeks to go until our SPPIRIT symposium A fantastic opportunity for ECR parasitologists across Scotland to network and showcase their research. 🗓️ 31 October 2025 | 📍 Roslin Institute, Edinburgh 🎟️ Free to attend → tinyurl.com/3yzjnm5h Secure your spot today!

Nisha Philip@nishaphilip.bsky.social · 11mo ago

Delighted to report our publication on a divergent cyclic nucleotide binding protein that regulates malaria transmission to mosquitoes. Great work by Domi Kwecka , @jennyregan.bsky.social @choel Kim #malaria #ookinete #mosquitoes #signalling journals.plos.org/plospathogen...

A divergent cyclic nucleotide binding protein promotes Plasmodium ookinete infection of the mosquito

Author summary Malaria parasites complete their life-cycle within mammalian and mosquito hosts requiring specialised forms to invade and establish infection in host tissue. In order to transmit to the...

journals.plos.org

EMBL Events@events.embl.org · last yr.

🔬✨'Women in Malaria' peer-to-peer workshop at #EMBLMalaria ♀️ This informal session brought together women across the #malaria community to share experiences, challenges, and strategies for navigating their careers and shaping the field. Grateful for the openness, insights, and energy in the room 🙌🏼

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Nisha Philip@nishaphilip.bsky.social · 2y ago

📣📣 🦟 Wondering what the putative EPAC in Plasmodium does. See our new study characterising a cryptic cyclic nucleotide binding protein required for mosquito infection by the ookinete. Well done Domi Kwecka and team #ookinete #malaria www.biorxiv.org/content/10.1...

A divergent cyclic nucleotide binding protein promotes Plasmodium ookinete infection of the mosquito

Colonisation of the mosquito by the malarial parasite is critically reliant on the invasive ookinete stage. Ookinete invasion of mosquito is coordinated by the apical complex, a specialised parasite s...

biorxiv.org

Abhinay Ramaprasad@abhinay.bsky.social · 2y ago

🥁🥁 Job alertttt!! Interested in weird biology of malaria parasites? Inducible genetic screens? Single-cell RNAseq? Come postdoc with us - www.parafugelab.com ! International applicants or applicants just finishing up their PhD, both welcome!! www.jobs.gla.ac.uk/job/research...

Research Assistant/Associate

Job Purpose We are seeking to recruit a motivated and creative Research Assistant/Associate (postdoctoral researcher) to work within an MRC-funded research programme https://gtr.ukri.org/projects?...

jobs.gla.ac.uk

Nisha Philip@nishaphilip.bsky.social · 2y ago

Repositioning Brusatol as a Transmission Blocker of Malaria Parasites

Currently, primaquine is the only malaria transmission-blocking drug recommended by the WHO. Recent efforts have highlighted the importance of discovering new agents that regulate malarial transmission, with particular interest in agents that can be administered in a single low dose, ideally with a discrete and Plasmodium-selective mechanism of action. Here, our team demonstrates an approach to identify malaria transmission-blocking agents through a combination of in vitro screening and in vivo analyses. Using a panel of natural products, our approach identified potent transmission blockers, as illustrated by the discovery of the transmission-blocking efficacy of brusatol. As a member of a large family of biologically active natural products, this discovery provides a critical next step toward developing methods to rapidly identify quassinoids and related agents with valuable pharmacological therapeutic properties.

pubs.acs.org