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Abhinay Ramaprasad

@abhinay.bsky.social

Malaria biologist. Can stitch together some code. MRC Career Development Fellow at School of Infection and Immunity, UofGlasgow @uofgsii.bsky.social. #NewPI. Fuelled by chai. www.parafugelab.com

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Paul Sigala@sigalalab.bsky.social · 5mo ago

Happy to announce a new review article by MD/PhD student Kade Loveridge on iron metabolism in #malaria #parasites. @uofubiochem.bsky.social @uuhsresearch.bsky.social @uofutahcihd.bsky.social @parasitesrule.org journals.plos.org/plospathogen...

Fifty shades of iron: Unorthodox mechanisms of iron acquisition and utilization in blood-stage Plasmodium parasites

Plasmodium falciparum parasites cause severe human malaria and depend on iron for essential metabolic processes during all phases of their complicated lifecycle, including when growing in human red bl...

journals.plos.org

@knuepferlab.bsky.social · 6mo ago

We are hiring! For more information on this 4-year project focussing on the molecular and temporal mechanisms of erythrocyte invasion by Plasmodium knowlesi parasites follow the link below. Exciting work in molecular parasitology and a great team are waiting for you :) jobs.rvc.ac.uk/vacancy.aspx...

Job Opportunity at the RVC: Postdoctoral Research Associate

We are looking for an enthusiastic and curiosity-driven Postdoctoral Research Associate to join our friendly, dynamic and growing discovery research group. The postholder will work in Dr Knuepfer’s gr...

jobs.rvc.ac.uk

bishara marzook@ghostpathogen.bsky.social · last yr.

Our paper has finally graduated from pre-print to peer-reviewed, pretty much unscathed, and is out now! www.cell.com/cell/fulltex...

The essential host genome for Cryptosporidium survival exposes metabolic dependencies that can be leveraged for treatment

An arrayed microscopy-based CRISPR screen revealed host genes affecting multiple infection phenotypes of the intracellular parasite Cryptosporidium. Hits in the host cholesterol biosynthesis pathway a...

cell.com

Marketa Novotna@marketanovotna.bsky.social · last yr.

I used inducible CRISPR/Cas9 to make Trypanosoma brucei cell line that allowed me to edit originally muti-copy histone gene. We uncovered a novel role of H4 histone tail in gene regulation. I enjoyed working on this exciting project with @joanarcf.bsky.social, a great mentor. doi.org/10.1038/s414...

Precision-edited histone tails disrupt polycistronic gene expression controls in trypanosomes - Nature Communications

Transcription in trypanosomatids, such as Trypanosoma brucei, is predominantly polycistronic and involves unconventional RNA polymerase II promoters. This study uses precision gene editing, site-satur...

nature.com

Omaya Dudin 𓂆 ¦🍉¦🦠¦🔬¦@dudinlab.bsky.social · last yr.

90% of you probably don’t need to read this. But maybe some of you are curious & 10% will feel seen. Or a little less alone. This isn’t about seeking sympathy. It’s about sharing something hard to say out loud; partly to heal, partly in case someone needs to hear it too. (1/3) tinyurl.com/DudinO

Omaya Dudin

Interview with Omaya Dudin, who uses Ichthyosporea as models to study how and why unicellular organisms evolved multicellularity at the University of Geneva.

cell.com

SheinerLab@sheinerlab.bsky.social · last yr.

Parasites need mitochondrial respiration to infect and spread. Effective anti-malaria and ani-toxoplasmosis drugs target respiratory complexes (e.g. atovaquone)! But how do the parasite complexes work and how do drugs inhibit them? Read Andrew Maclean and Alex Mühleip phenomenal work on this! 👇

Andrew Maclean@macleanlab.bsky.social · last yr.

Happy to share our latest paper. Result of a great collaboration between @sheinerlab.bsky.social @oninopantsu.bsky.social and Alexander Mühleip’s new group. www.nature.com/articles/s41...

Dr. Mattie Christine Pawlowic@goldenpipette.bsky.social · last yr.

If you have ever wanted to know "Where is the gut is the parasite?" this pre-print is for you. 🐮 Led by Peyton, with thanks to our wonderful collaborators at @moredunfoundation.bsky.social Frank Katzer, @geordieparasit.bsky.social and EMs by @lemgruber.bsky.social www.biorxiv.org/content/10.1...

Tissue atlas of Cryptosporidium parvum infection reveals contrasts between the natural neonatal calf model and laboratory mouse models

Cryptosporidium is an apicomplexan parasite that causes diarrhoeal disease. The species C. parvum is zoonotic and causes significant morbidity and mortality for both humans and farm animals; most comm...

biorxiv.org