Disease Transcriptomics (NMorais) Lab
@nmoraislab.bsky.social
Disease Transcriptomics Lab, led by Nuno Barbosa-Morais, at the NOVA Medical School in Lisbon, Portugal. https://diseasetranscriptomicslab.github.io/
🧬 From Data to Discovery! On 9 October, @biomics-twinning.bsky.social welcomed @ebi.embl.org experts to @gimminstitute.bsky.social for a full day of #UniProt training with 15 participants, a Biomedical Data Science Seminar and a new BIOMICS Friends interview! 🎥 #BIOMICS #UniProt #Bioinformatics
Thanks to the support of @biomics-twinning.bsky.social and @embo.org YIP, Nuno is now a Certified Night Science Trainer, after attending the wonderful “train the trainer” event at @embl.org Heidelberg last week, led by the two and only @itaiyanai.bsky.social and @martinlercher.bsky.social.
Itai Yanai@itaiyanai.bsky.social · last mo.This week we held our second-ever “train the trainer” event in Heidelberg at EMBO/EMBL to pass on our teachings on the creative scientific process to 50 instructors. We're on our way to achieving our mission of bringing creativity training to all scientists worldwide!
New preprint 📣! We reanalysed stress granule transcriptomes and found differential centrifugation is strongly biased by RNA length. Correcting for this erases most reported overlap. Mitochondrial RNAs remain as a modest signal, hinting at immune signalling. doi.org/10.64898/202...
When the PI’s away, the Lab will happily and productively play. 🙂
Garbage In, Plot Out 🧠 A bioinformatics pipeline will always give you something: a plot, a p-value, a cluster. It won’t tell you whether the parameters you chose were the right ones. That’s the black box problem in bioinformatics 📊. A thread on why critical thinking matters 🧵
🚀 Our new research lab website is now live! After a few months of moving, settling in, and rebuilding, the Disease Transcriptomics Lab is now online: diseasetranscriptomicslab.github.io Find out more about our research, tools, people, ethos, and opportunities to join us.
Disease Transcriptomics Lab · NMorais Lab
Decoding transcriptomes to understand disease. Computational biology research at NOVA Medical School, Lisbon.
diseasetranscriptomicslab.github.io
Finally out, a much improved peer-reviewed article published in NAR Genomics & Bioinformatics @academic.oup.com. 👏 @ritamtbs.bsky.social and @a-kaizeler.bsky.social! academic.oup.com/nargab/artic...
Exploring molecular signatures of senescence with marker, an R Toolkit for evaluating gene sets as phenotypic markers
Abstract. Many biological processes, including cellular senescence, manifest as diverse phenotypes across cell types and conditions. Lacking definitive mar
academic.oup.com
Disease Transcriptomics (NMorais) Lab@nmoraislab.bsky.social · 11mo agoFollowing the @bioconductor.bsky.social package, the @biorxivpreprint.bsky.social preprint: "Exploring molecular signatures of senescence with markeR, an R toolkit for evaluating gene sets as phenotypic markers". 💻🧬📰 👏 @ritamtbs.bsky.social 💪 www.biorxiv.org/content/10.6...
🎥 NEW Getting to know BIOMICS Members episode! Meet @mirimiam.bsky.social from @crg.eu, sharing his scientific journey, perspectives on collaboration, and research in evolutionary medical genomics. 📺 youtu.be/T5ZpgSiowY8 #BIOMICS #HorizonEurope #Genomics #BiomedicalScience
BIOMICS Core Member: Manuel Irimia
YouTube video by BIOMICS Twinning
youtu.be
🚀 Today’s #BIOMICS course at @gimminstitute.bsky.social: A packed room exploring #probabilistic #model #building, #Bayesian thinking, #AI, diffusion models, and active learning 🧠📈 Fantastic discussions and engagement throughout the day! #BIOMICS #AI #DataScience #MachineLearning #HorizonEurope
🚨 Now at @gimminstitute.bsky.social, Mafalda Dias & Jonathan Frazer, from @crg.eu talking about how we can read #evolutionary constraints with #deep #learning. #EUfunded #BIOMICS #EvoMG
My Working Life article @science.org - When I stopped trying to have all the answers, my lab members thrived | Science | AAAS www.science.org/content/arti...
When I stopped trying to have all the answers, my lab members thrived
This professor learned “to be there when people struggled without taking the wheel,” he writes
science.org
Happening now 🚨 #BIOMICS Seminar by Manuel Irimia on “Evolutionary landscapes of zygotic genome activation across animals” 📍 In-person at GIMM Lisboa + live on Zoom #BIOMICS #Seminar #Genomics #ZGA @mirimiam.bsky.social @nmoraislab.bsky.social
The Lab was well represented at the Bioinformatics Open Days @uminho.bsky.social (25-27 March), with Nuno giving a keynote lecture and @a-kaizeler.bsky.social, Francisca, and @ritamtbs.bsky.social presenting posters.
What comes after academia? 🤔 At our latest #BIOMICS workshop @GIMM, 17 participants explored career paths beyond the lab — working hands-on on CVs & LinkedIn profiles 💼 Thanks to our partners @crg.eu 🙌 🇪🇺 #HorizonEurope #FundedByEU #BeyondAcademia #PhDLife
We proudly have a new Master! 🥳 Our @djmarques.bsky.social stellarly defended his MSc dissertation, evaluated with a perfect 20/20! 🤓👏
On the last 25th of February, Nuno introduced the Lab to our new colleagues in a seminar entitled "Thinking critically about big data at NOVA Medical School". It was very well attended (don't be fooled by the empty first couple of rows) and received. We feel very welcome at NMS! 😊
Happy International Day of Women and Girls in Science! 👩🔬
Nuno will, proudly and enthusiastically, repeat as one of the lecturers of the pioneering ISCTE EE Postgraduate Course in Critical Thinking for Decision Making (execed.iscte-iul.pt/en/applied-o...), brilliantly coordinated by José Maria Pimentel.
Disease Transcriptomics (NMorais) Lab@nmoraislab.bsky.social · 2y agoNuno will proudly and enthusiastically be one of the lecturers of the pioneering ISCTE EE Postgraduate Course in Critical Thinking for Decision Making (execed.iscte-iul.pt/applied-onli...), brilliantly coordinated by José Maria Pimentel.
On World Cancer Day, Francisca's PhD project was awarded an Oncology Research Grant by the Portuguese League Against Cancer (Southern Regional Center) and the Benfica Foundation, to support her work on testing predictive biomarkers of therapeutic response in rectal cancer. 🙏🦀⚕️💪
We are proud of the Lab's participation in the CAML & GIMM PhD Meeting this week: @a-kaizeler.bsky.social, @ritamtbs.bsky.social and Francisca eloquently presented their work to their colleagues 👏. @ritamtbs.bsky.social won the award for Best Poster Presentation by a 4th year PhD student! 🥇
Following the @bioconductor.bsky.social package, the @biorxivpreprint.bsky.social preprint: "Exploring molecular signatures of senescence with markeR, an R toolkit for evaluating gene sets as phenotypic markers". 💻🧬📰 👏 @ritamtbs.bsky.social 💪 www.biorxiv.org/content/10.6...
Exploring molecular signatures of senescence with markeR, an R toolkit for evaluating gene sets as phenotypic markers
Many biological processes, including cellular senescence, manifest as diverse phenotypes that vary across cell types and conditions. In the absence of single, definitive markers, researchers often rel...
biorxiv.org
Rita Martins-Silva@ritamtbs.bsky.social · last yr.🚀 Exciting news: markeR is now available in the Bioconductor development version and will be part of the new release 3.22, scheduled for October 29! 🎉 Give it a try and let us know what you think! 🔗 bioconductor.org/packages/dev...
⏰ Only 1 day left to apply! Applications for the EvoMG-DN PhD positions close tomorrow. If you plan to apply, this is your final chance. Submit your application here → www.evomg-dn.eu #PhD #DoctoralTraining #ResearchCareers #LifeSciences #BiomedicalResearch #Genomics #EvolutionaryBiology #MSCA
Our Maria successfully defended her MSc dissertation on Tuesday afternoon and still found the energy to present her work on the isoform-specific impact of mutations in CDKN2A in cancer again the following morning, at the 9th Annual Conference of ULisboa redeSAÚDE. 💻🧬 👏🍾 💪
Before you submit your application, make sure you have everything ready: ✔ 2 referee details ✔ Academic transcripts ✔ Confirmation that you meet all eligibility criteria You can still apply through our website → www.evomg-dn.eu #PhD #LifeSciences #BiomedicalResearch #Genomics #EvolutionaryBiology
#Postdoc alert! We are looking for motivated individual with experience in computational systems biology to join our NetworkCommons initiative to benchmark and democratise network contextualisation methods across multiple applications. Deadline Dec 17th link here: tinyurl.com/yrrzxa94
Postdoctoral fellow - Petsalaki Group - NetworkCommons
Your group The Petsalaki, Saez-Rodriguez (EMBL-EBI) and Korcsmáros (Imperial College) groups develop cutting-edge computational and AI approaches to unravel cellular signalling and gene regulation fro...
tinyurl.com
We’re excited to introduce @mirimiam.bsky.social (@crg.eu ), one of our EvoMG-DN PIs! Explore the project and PhD details on our website → www.evomg-dn.eu #PhD #DoctoralTraining #ResearchCareers #LifeSciences #BiomedicalResearch #Genomics #EvolutionaryBiology #MSCA #HorizonEurope #EUResearch
Only one week left to apply for the EvoMG-DN PhD programme. All details and application info → www.evomg-dn.eu #PhD #DoctoralTraining #ResearchCareers #LifeSciences #BiomedicalResearch #Genomics #EvolutionaryBiology #MSCA #HorizonEurope #EUResearch #ResearchOpportunities #InternationalResearch
Front row view of our Maria smoothly presenting her MSc dissertation work on the isoform-specific impact of mutations in CDKN2A in cancer at the Oncobiology Club @gimmfoundation.bsky.social. 💻🧬👏
