Our MASLD paper is finally out @naturemetabolism.bsky.social @ebi.embl.org @opentargets.org ! Fantastic collaboration with Toni Vidal-Puig's group in the IMS, UCam (co-led), Papatheodorou @earlhaminst.bsky.social and other coauthors, led by Ioannis Kamzolas and Thodoris Koutsandreas. Check it out!

Open Targets@opentargets.org · 3w ago

Out now in Nature Metabolism! 🖥️🧬 An Open Targets project has identified a set of plasma proteins that could be used to diagnose and monitor patients with Metabolic dysfunction-Associated Steatotic Liver Disease (MASLD) www.nature.com/articles/s42...

New preprint alert! We integrated plasma proteomics, whole-blood transcriptomics, machine learning and network propagation to dissect high-risk thrombotic primary antiphospholipid syndrome (APS). 🩸🧬https://www.medrxiv.org/content/10.64898/2026.06.26.26356680v1

Can GNNs really learn biology, or just graph topology? Our new preprint shows that GNNs predict gene essentiality better only when using real biological interaction networks. Biological network organization, not generic graph topology, drives prediction. www.biorxiv.org/content/10.6...

Last call for our open Group Leader position at VIB.AI and Ghent University! Focus: AI in (bio)medicine Don’t miss this opportunity 👉 https://vib.ai/en/group-leader-vacancy

Join us: deliverome.org/careers More on the Deliverome Project: ifp.org/the-delivero... Follow along: deliverome.org

The Deliverome Project

An open receptor atlas for targeted delivery beyond the liver, integrating abundance, specificity, internalization, and routing.

deliverome.org

Grant writing tips from a grumpy reviewer ploughing through grants. 1. Often your reviewers are going to come from a broad range disciplines adjacent but *not actually in* in your field. Help us get orientated in the summary with an analogy/sketch and go back to analogy / sketch throughout.

King's College London are seeking a Lecturer in Applied Mathematics (Quantitative Modelling) to "develop an independent research programme in applied mathematics, mathematical modelling, or a closely related area" www.jobs.ac.uk/job/DRG116/l...

Lecturer in Applied Mathematics (Quantitative Modelling) at King's College London

Recruiting now: Lecturer in Applied Mathematics (Quantitative Modelling) on jobs.ac.uk. Click for details and explore more academic job opportunities on the top job board

jobs.ac.uk

Is #AI hitting a plateau in structure prediction? Help us find out at CASP17! 🧪🧬 Calling for Targets: Immune Complexes, protein - ligand complexes, RNA/DNA, conformational ensembles, membrane proteins, viral origins, and large complexes. The Rule of Thumb: If AF3 can’t model it, we want it.

We’re recruiting new Research Group Leaders! Why join? 🌍Work across EMBL’s 6 sites 🎓Participate in @embl.org courses and seminars 🔬Lead discovery-driven research in a collaborative environment Apply by 11 April: embl.wd103.myworkdayjobs.com/en-US/EMBL/j... #ResearchCareers @epetsalaki.bsky.social

Thank you very much for hosting me!

Elo Lab@elolab.bsky.social · 5mo ago

Thanks to Evangelia Petsalaki for the inspiring Frontiers of Science seminar: “Network-based approaches to study context-specific signalling”. It was a pleasure to learn about the exciting work from your lab and have great scientific discussions. @epetsalaki.bsky.social @turkubioscience.bsky.social

Our preprint is published in MSB! This time with the correct preprint post below! link.springer.com/article/10.1...

Integrative multi-omics defines melanoma drug response networks and ARID1A-dependent resistance mechanisms - Molecular Systems Biology

Resistance to BRAF/MAPK inhibitors is a significant challenge in melanoma treatment, driven by adaptive and acquired mechanisms allowing tumor cells to evade therapy. We explored early signaling respo...

link.springer.com

Evangelia Petsalaki@epetsalaki.bsky.social · 2y ago

We are proud to present "ARID1A-induced transcriptional reprogramming rewires signalling responses to drug treatment in melanoma" led by Charlie Barker and Sumana Sharma in collaboration with EPIC-XS Utrecht, ProtAvio, @sangerinstitute.bsky.social and UofAthens www.biorxiv.org/content/10.1...

This #RareDiseaseDay, we’re highlighting how open data sharing supports diagnosis, research, and families living with rare conditions. Watch to find out how access to rare disease data through @deciphergenomics.bsky.social can help families better understand their children’s rare conditions.

Our thoughts, impressions, and presentations of the "2nd EuroDepMap symposium" in Milan (Nov 2025) are online at @febsletters.bsky.social. febs.onlinelibrary.wiley.com/doi/10.1002/...

FEBS Press

Held on 20 November 2025 at Human Technopole in Milan, the 2nd European Cancer Dependency Map Symposium convened experimental and computational scientists to discuss how cancer dependency mapping in ...

febs.onlinelibrary.wiley.com

Our preprint is now published in MSB. link.springer.com/article/10.1... We decompose multi-omics into distinct phenotypic axes (drug response vs ARID1A-driven cell state), improving interpretation and revealing how baseline cell state rewires signaling and shapes MAPK inhibitor resistance.

Integrative multi-omics defines melanoma drug response networks and ARID1A-dependent resistance mechanisms - Molecular Systems Biology

Resistance to BRAF/MAPK inhibitors is a significant challenge in melanoma treatment, driven by adaptive and acquired mechanisms allowing tumor cells to evade therapy. We explored early signaling respo...

link.springer.com

Evangelia Petsalaki@epetsalaki.bsky.social · 2y ago

New preprint from our group @ebi.embl.org and the Vidal-Puig group! We combined pseudotemporal ordering of cross sectional MASLD patient data with network analysis to describe the disease progression and identify a signature of 24 plasma biomarkers for patient staging www.biorxiv.org/content/10.1...

Do you want to pursue your ideas in computational biology independently, running your group in @embl.org‘s uniquely collaborative environment, beside world’s most comprehensive biomolecular data resources @ebi.embl.org in Genome Campus next to @sangerinstitute.bsky.social? Apply to join us & share 🙏

EMBL-EBI@ebi.embl.org · 6mo ago

We’re hiring: Research Group Leader in computational biology. Are you generating more research ideas than you can explore? Lead cutting-edge AI & biology research at EMBL-EBI. Apply by 11 April 2026: embl.wd103.myworkdayjobs.com/en-US/EMBL/j... #ScienceCareers @ewaldlab.org @embl.org

📢 This Week at #IRBBarcelona: Join us for a plenary #seminar this Friday, with Dr. @isidrolauscher.bsky.social from @ebi.embl.org @sangerinstitute.bsky.social @cancerresearchuk.org  🤝 Hosted by @nlbigas.bsky.social and @milanlab.bsky.social  Register here ➡️ https://shorturl.at/imwHx 🧪

Looking for bioinformatician for exciting projects across the Centre of Genomics at the Human Technople. We also work with the FANTOM6 Consortium and other international consortia/projects. Details below: careers.humantechnopole.it/job/Bioinfor...

Rewiring of oncogenic signaling in #DrugResistance is a moving target. In our new study, we used biophysical phosphoproteomics to investigate #BRAF mutant cancer, linking phosphorylation changes to protein function and #MolecularMechanisms through #Multi-Omics integration. tinyurl.com/funsignaling

We’re hiring: Research Group Leader in computational biology. Are you generating more research ideas than you can explore? Lead cutting-edge AI & biology research at EMBL-EBI. Apply by 11 April 2026: embl.wd103.myworkdayjobs.com/en-US/EMBL/j... #ScienceCareers @ewaldlab.org @embl.org

Meet Leonie Johanna Lorenz 🇩🇪, a Predoctoral Fellow at EMBL-EBI who is bringing mathematical modelling to microbes. Find out more about how Leonie’s passion for modelling patterns extends from bacterial evolution to sewing 🧵 www.ebi.ac.uk/about/news/p...

Indeed an amazing place to start your group! Don't miss the opportunity!

John Lees@johnlees.bacpop.org · 6mo ago

We are hiring for group leaders again — EBI is a great place to start your research group! embl.wd103.myworkdayjobs.com/EMBL/job/Hin...

Pervanadate is more than just a phosphatase inhibitor! Read our paper just published in #sciencesignaling showing that pervanadate oxidises and activates SRC kinase too. Link: tinyurl.com/5ype7e2s Thanks for the 'focus' by: @nshahlab.bsky.social tinyurl.com/54fcjds3 @babrahaminst.bsky.social

Pervanadate-induced oxidation relieves autoinhibition of the protein tyrosine kinase SRC

A widely used tyrosine phosphatase inhibitor also oxidizes and activates the tyrosine kinase SRC.

science.org

EMBL is deeply saddened by the passing of our Interim Director General Peer Bork, a pioneering scientist who left an indelible imprint on life science research in Europe and beyond. We extend our deepest condolences to his family, friends, and colleagues. www.embl.org/news/people-...

Truly shocked and saddened by the loss of this brilliant man, scientist and mentor.

Lars Juhl Jensen@larsjuhljensen.bsky.social · 7mo ago

I think I speak for all alumni when I say that I am still in shock. Peer was a great scientist, but more importantly a great person.

On this day in 2021, I landed in a snowy, lockdown-silenced Heidelberg to start my lab. 5 years later we are a force to reckon with in our field, and the first generation are striking out on their own. I couldn’t be more proud, & grateful to them and our wonderful collaborators around the world 🌍 🧪

Looking to start your lab in generative biology / AI? Come join us at the @sangerinstitute.bsky.social Sanger is core-funded so you can generate data at scale to train the next generation of models and understanding. Design/Engineering/Chemistry/Proteins/Pathways! pls RT tinyurl.com/GenGenFaculty

HIRING: We recruit PhD students via the AITHYRA-CeMM PhD Program (cemm.at/phd-program). Seeking 3 types of candidates: (1) experimental systems biology in immunity or cancer; (2) bioinformatics & biomedical ML/AI; (3) tech-dev & bioengineering (CRISPR, single-cell, spatial, cell programming) (1/5)

CeMM PhD Program – Molecular Medicine Research in Vienna

Join the CeMM PhD Program in Vienna and pursue cutting-edge research in cancer, immunology, aging, and precision medicine. Applications open in 2025!

cemm.at

1/ We’re hiring PIs in AI × Biology The @astar-gis.bsky.social Genome Institute of Singapore (GIS) is expanding its AI & Computation domain and recruiting junior & senior PIs.

Our Human Genetics team @boehringerglobal.bsky.social (Biberach site, Germany) is actively searching for an experienced Statistical Geneticist. #StatisticalGenetics #HumanGenetics #BoehringerIngelheim #ComputationalInnovation #JobOpportunity lnkd.in/g6QPihVE

From @irbbarcelona.org #ICREAResearcher Patrick Aloy @ptck72.bsky.social has taken part in a study published in @nature.com that broadens the possibilities for designing more effective drug therapies 👇

IRB Barcelona@irbbarcelona.org · 8mo ago

🧬 Kinase Inhibitors can do more than block their targets! A study by @cemm.oeaw.ac.at-@aithyra.bsky.social and #IRBBarcelona reveals that many inhibitors also trigger the degradation of the kinases, uncovering an overlooked mechanism with therapeutic potential. Out in @nature.com ➡️ bit.ly/43SD9xj