Excited to announce a new paper out today in Cancer Discovery @aacrjournals.bsky.social on clinical mechanisms of resistance to BTK degraders. Led by @quinnsievers.bsky.social and part of our ongoing collaboration with Meghan Thompson, Nurix Therapeutics & Justin Taylor (U. Miami):

Excited to present the first pre-print from our group, an investigation the human bone marrow microenvironments in patients with myelodysplastic syndromes (MDS) and normal age-matched subjects using Xenium genotype-informed spatial transcriptomics: www.biorxiv.org/content/10.6...

Excited to announce a new paper out now in Cancer Discovery @aacrjournals.bsky.social on a unique CAR T cell platform that eliminates AML and B-ALL without harming vital endogenous immune cells or other normal human tissues: pubmed.ncbi.nlm.nih.gov/42059863/

Excited to announce a new paper out today in Nature Genetics identifying a new approach to mitigate the risk of therapy-related myeloid malignancies in patients with cancer. Collaboration with Kelly Bolton’s lab @kellybolton.bsky.social @washumedicine.bsky.social www.nature.com/articles/s41...

CDK4/6 inhibition mitigates chemotherapy-induced expansion of TP53-mutant clonal hematopoiesis - Nature Genetics

Analysis of clinical trial data suggests that CDK4/6 inhibitors prevent the expansion of TP53-mutant clones in the blood, potentially mitigating the risk of secondary myeloid neoplasms in patients tre...

nature.com

Excited to announce a new publication from our @mskcancercenter.bsky.social Histiocytosis group identifying a predictor for impaired response to MEK inhibition in histiocytosis patients and potential for ERK inhibition. Out today in @Cancer_Cell. www.sciencedirect.com/science/arti...

RAF-independent MEK mutations drive refractory histiocytic neoplasms but respond to ERK inhibition

Histiocytic neoplasms are clonal disorders of the monocyte/macrophage lineage defined by mutations activating mitogen-activated protein kinase (MAPK) …

sciencedirect.com

Excited to announce a new paper in ‪@aacrjournals.bsky.social‬ with Junwei Shi and Tony Daniyan. We perform screens of GAPs and GEFs in AML and discover a hematopoietic-specific GAP (ARHGAP45) required in a variety of hematologic malignancies: aacrjournals.org/cancerdiscov...

Now online in Cancer Discovery @aacrjournals.bsky.social: Systematic Evaluation of GAPs & GEFs Identifies a Targetable Dependency for Hematopoietic Malignancies - by Pu Zhang, Zhendong Cao, Anthony Daniyan, Omar Abdel-Wahab, Junwei Shi, et al. doi.org/10.1158/2159...

Excited to announce our annual New York City Edward P. Evans MDS Centers Symposium across @mskcancercenter.bsky.socia & @columbiacancer.bsky.social. This year to be held at @mskcancercenter.bsky.socia. See this flyer below and register here: forms.fillout.com/t/1wX3dGmym4us

Excited to announce a new paper out today in @cp-cell.bsky.social discovering RNA mis-splicing derived neoantigens & their cognate T cell receptors (TCRs) as well as characterization of endogenous neoantigen T cells in leukemia patients. authors.elsevier.com/sd/article/S...