@neuroweiler.bsky.social, @olechsylte.bsky.social and Matilda Cloves are presenting posters tomorrow (8 July) 🙌

Ever wondered what having auditory stimulation does to the sleep itself? Random stimulation disturbs SWS, memory, and travelling dynamics of slow waves. New paper in iScience with @mschoenauer.bsky.social, @denizkumral.bsky.social, and Steffen Gais! doi.org/10.1016/j.is... #sleep #neuroskyence

Fantastic news for IN-CODE! Prof. Marlene Bartos (Uni Freiburg) secured a €2.5M ERC Advanced Grant for "ReMember-CA3". Her team will investigate how the hippocampal CA3 circuit encodes memories without overwriting old ones, and how it retrieves them over extended periods of time. #ERC #Neuroscience

Calling all neuroscience postdocs! Come and share your work with the London neuroscience community. No CVs, publication records or recommendation letters needed. Learn more about SWC’s Emerging Neuroscientists Seminar Series and apply by 30 June: www.sainsburywellcome.org/web/content/...

Latest article from the lab is out: "Behavioral dynamics of different stages of sexual motivation in male and female rats".

Behavioral dynamics of different stages of sexual motivation in male and female rats

Sexual motivation is a complex concept involving both the initial drive to begin mating and the motivation to sustain copulation. Disruptions in sexua…

sciencedirect.com

I’m happy to share our new paper (with @mbartos.bsky.social) now out in Nature Neuroscience: "The dentate gyrus efficiently converges LEC and MEC inputs into multimodal, highly specific and reliable environmental representations" Download it @ rdcu.be/famDE More below 🧵

Out now in @plos.org CB: doi.org/10.1371/jour... Neural representations of tasks change over time, even in the absence of changes in task performance. But neurons change tuning at different rates. How does a neuron's stability relate to its interactions with the population? #compneuro #neuroskyence

Information theoretic measures of neural and behavioural coupling predict representational drift

Author summary Activity in the brain represents information about the outside world and how we interact with it. Recent evidence shows that these representations slowly change day to day, while memori...

doi.org

Thrilled to finally share this work! 🧠🔊 Using a new reinforcement-free task we show mice (like humans) extract abstract structure from sound (unsupervised) & dCA1 is causally required by building factorised, orthogonal subspaces of abstract rules. Led by Dammy Onih! www.biorxiv.org/content/10.6...

Congratulations to @olechsylte.bsky.social on receiving a Marie Skłodowska-Curie Actions (MSCA) Postdoctoral Fellowship! 🎉 Ole will investigate how the brain transforms spatial knowledge into goal-directed actions.

New preprint from the lab! A frontal motor circuit for economic decisions and actions: www.biorxiv.org/content/10.6... We use a novel task in mice, cortex-wide imaging and optogenetics, NPX recording and modelling to reveal a circuit mechanism that transforms abstract decisions to spatial actions.

A frontal motor circuit for economic decisions and actions

Flexible behaviour requires transforming abstract cognitive representations, such as value preferences, into concrete motor actions. During economic decision-making, individuals evaluate options to gu...

biorxiv.org

Please share! 🧠 Opportunity for a PhD position: Studying interneurons and memory, using cutting-edge techniques, such as patch-clamp electrophysiology, in vivo calcium imaging, optogenetics and behavioral experiments. Interested? Have a look here for more information: www.fens.org/careers/job-...

Now that the science days are over, I can happily share some of my designs :) Thanks to all the @in-code.bsky.social members who made these days a success! It was intense but worth it! And huge thanks to @sophiekb.bsky.social that was in charge of making this happen

🙋Are you interested in bridging theory & experiments? Applications are now open for 2026 entry to the Gatsby Unit & SWC joint PhD programme. Join us and be part of a vibrant research community! 💰 Fully-funded 4-year programme ℹ️ www.ucl.ac.uk/life-science... @sainsburywellcome.bsky.social

Applications are now open for the SWC Systems Neuroscience PhD Programme. Join us in London! 🧠 World-class neuroscience training 💰 Fully-funded 4-year programme 🖥️ Close links to @gatsbyucl.bsky.social Apply by 3 Nov: www.sainsburywellcome.org/web/content/...

🚨New paper alert! We studied the long-term consequences of SSRI use during pregnancy on the offspring in rats in a seminatural environment. We found that perinatal FLX exposure significantly increases sexual behavior in adult male rats. @uitnorgesarktiske.bsky.social #neuroscience #neuroskyence

Perinatal fluoxetine exposure increases male rat sexual behavior

Selective serotonin reuptake inhibitors (SSRIs) are commonly prescribed to pregnant women due to their efficacy and safety profile, leading to potenti…

sciencedirect.com

And for me the big question is: What about representational drift? 😄 Manifolds can be mapped, but individual neuronal responses change. That’s neat, but how does it make sense? How can perception stay stable if the neurons keep changing? I’m sure manifolds will help us understand that too… 🧠🧪 3/3

🚨 New Article Alert! 🚨 Our latest research reveals how long-term consumption of a cafeteria (CAF) diet impacts the ventral tegmental area in rats. 🍔🍟🍩#Neuroskyence @uitnorgesarktiske.bsky.social www.sciencedirect.com/science/arti...

Behavioral and neural alterations of the ventral tegmental area by exposure to junk food in rats

The brain reward system is essential for regulating appetitive and consummatory behaviors in response to various incentive stimuli. Junk food, charact…

sciencedirect.com

New preprint alert! Perinatal fluoxetine exposure increases male rat sexual behavior. @uitnorgesarktiske.bsky.social #neuroscience #neuroskyence

bioRxiv Neuroscience@biorxiv-neursci.bsky.social · last yr.

Perinatal fluoxetine exposure increases male rat sexual behavior https://www.biorxiv.org/content/10.1101/2025.05.26.656113v1

A non-value-based system in the brain automates decision-making and frees up cognitive resources for other tasks, a new study in mice suggests. By Holly Barker #neuroskyence www.thetransmitter.org/neurobiology...

Dopamine neurons signal default behavior to reinforce habits

Movement-sensing neurons in the striatum influence a mouse’s choice of action by favoring routine behaviors.

thetransmitter.org

A new paper from the group is online: we show that longterm low-frequency stimulation alleviates seizures beyond stimulation periods and reverses epilepsy-associated synaptic alterations. #TrEPILab www.sciencedirect.com/science/arti...

Long-term hippocampal low-frequency stimulation alleviates focal seizures, memory deficits and synaptic pathology in epileptic mice

Mesial temporal lobe epilepsy (MTLE) is a prevalent form of focal epilepsy characterized by seizures originating from the hippocampus and adjacent reg…

sciencedirect.com

Looking forward to an exciting Spring Hippocampal Research Conference in Verona with @mbartos.bsky.social @olechsylte.bsky.social @federicotorelli.bsky.social and @ute-fr.bsky.social

Impressive study in @nature from my colleague Marcus Stephenson-Jones at UCL in the @sainsburywellcome.bsky.social www.nature.com/articles/s41...

Dopaminergic action prediction errors serve as a value-free teaching signal - Nature

Dopaminergic action prediction error signals are used by mice as a value-free teaching signal to reinforce stable sound–action associations in the tail of the striatum.

nature.com

Read the full paper ‘Dopaminergic action prediction errors serve as a value-free teaching signal’ in @natureportfolio.nature.com @gatsbyucl.bsky.social @imperialcollegeldn.bsky.social www.nature.com/articles/s41...

Dopaminergic action prediction errors serve as a value-free teaching signal - Nature

Dopaminergic action prediction error signals are used by mice as a value-free teaching signal to reinforce stable sound–action associations in the tail of the striatum.

nature.com

Congrats to Aurore Gazala for winning the Eve Marder Best Paper Prize for “Subfield-specific interneuron circuits govern the hippocampal response to novelty in male mice” (Nat Comm, 2024) - awarded in person by Eve Marder at the IN-CODE retreat in Potsdam! @acazala.bsky.social #interneurons

Play the "IBNS 2025 Reindeer Games Contest"! Share one of the reindeer adds on social media and get the most likes! @ibnsconnect.bsky.social 1st prize - $100 Gift Card or $200 off IBNS Registration 2nd prize - Free one year IBNS regular membership or two years Student/Postdoc membership

Don't miss your last chance to attend IBNS in Tromsø!

Eelke Snoeren@eelkesnoeren.bsky.social · last yr.

What about visiting a neuroscience conference in Europe this year? There is still time to register for IBNS in Tromsø (June 24th-29th 2025)! Please like and share! For more information: www.ibnsconnect.org/annual-meeting @ibnsconnect.bsky.social #neuroskyence

🔬🤝🎨 Drawing over my 2photon recordings of axons in the dentate gyrus for our last picture contest ✨️

Check our new manuscript on ‚Coordinated representational drift supports stable place coding in the hippocampal CA1’ by Ole Sylte, Antje Kilias, Marlene Bartos and Jonas Sauer. www.biorxiv.org/content/10.1...

Coordinated representational drift supports stable place coding in hippocampal CA1

The phenomenon of representational drift (i.e., changing neuronal tuning during repeated exposure to the same stimuli), is a fundamental paradox in neuroscience that raises the question how stable beh...

biorxiv.org

New paper out! We found functional neuron classes in the mPFC with different spatial tuning properties (generalised vs. trajectory-specific) and distinct contribution to the encoding of task space. Great job by the first author Hannah! www.cell.com/cell-reports...

Conjoint generalized and trajectory-specific coding of task structure by prefrontal neurons

Neurons in the medial prefrontal cortex (mPFC) show spatially modulated activities. Muysers et al. show that mPFC neurons fall into distinct functional classes that differ in terms of their spatial tu...

cell.com

New from the lab!! 👉🏼 authors.elsevier.com/a/1kgT43BtfH... 📝 @cellpress.bsky.social We discovered that genetically-defined neuron types in the hippocampus form unique manifolds! Dual color imaging, chemogenetics and topological analysis all at once! With Juan Gallego @juangallego.bsky.social