New publication from our lab at @hfhs-bjc.bsky.social! In this manuscript we describe the acute effects of intra-articular injection of liposome-encapsulated IDO-1 following ACL rupture. authors.elsevier.com/sd/article/S...

Acute local and systemic effects of intra-articular administration of liposomal Ido-1 following anterior cruciate ligament rupture

Joint injuries, such as rupture of the anterior cruciate ligament (ACL), are associated with the development of post-traumatic osteoarthritis (PTOA). …

authors.elsevier.com

Fantastic new article from the Gardinier Lab! Comprehensive in vitro and in vivo work to show the role of ARHGEF3 deletion in bone formation.

Henry Ford Bone & Joint Center@hfhs-bjc.bsky.social · 2mo ago

🚨🚨 New Publication Alert!!! 🚨🚨 The Gardinier Lab just published new research in the Journal of Bone and Mineral Research @asbmr.bsky.social! They demonstrated the effects of ARHGEF3 deletion on #bone formation and resorption! Check it out here: academic.oup.com/jbmr/advance...

Guess I've been walking widdershins for no reason at all.

Nature Portfolio@natureportfolio.nature.com · 2mo ago

A study in Nature Communications demonstrates that counterclockwise bias in roaming pedestrians is a robust and reproducible feature and originates from individual tendencies rather than from collective interactions. go.nature.com/3RUObPv ⚛️🧪

St. Clair County represent!!! @pwhl--detroit.bsky.social

PWHL Detroit@pwhl--detroit.bsky.social · 2mo ago

Port Huron's finest 😌

Favorite part of the @tigers.bsky.social game tonight. #Detroit

New pre-print up on bioRxiv! In it, we discuss the acute effects of intra-articular IDO-1 administration after ACL injury. Inflammatory cytokines ⬇️. Circulating Tregs⬆️. Joint tissue CTLA4+ cells ⬆️. And more! www.biorxiv.org/content/10.6...

Acute Effects of Intra-Articular Liposomal IDO-1 following Anterior Cruciate Ligament Injury

Joint injuries, such as rupture of the anterior cruciate ligament (ACL), is associated with the development of post-traumatic osteoarthritis (PTOA). It is known that ACL rupture can lead to disruption...

biorxiv.org

Awesome to see our Department Chair @shouldergeek.bsky.social and members of the @henryfordhealth.bsky.social Sports Med team at America's Thanksgiving Parade in #Detroit!

Who says PIs dont stand by their posters!? Presenting our ACL reconstruction research at #TERMISAM2025 in #Detroit.

Fantastic time at the 18th World Congress of the International Cartilage Regeneration & Joint Preservation Society in Boston. Presented our work on IDO-1 and #Kynurenines in #osteoarthritis, and a project focused on improved healing in #ACL reconstruction. As always - huge thanks to the team!

Another great publication from @amandality.bsky.social and team! Sure does make one reconsider the old "wear and tear" hypothesis about #osteoarthritis. Exciting times in OA research!

Henry Ford Bone & Joint Center@hfhs-bjc.bsky.social · 11mo ago

🚨🚨 New Publication Alert: The Ali Lab published a review on advancements in genomics, genetics, and epigenetics of #osteoarthritis. Fantastic work Thomas Wilson, Madhu Baghel and @amandality.bsky.social! www.oarsijournal.com/article/S106...

Sharing our new publication on the topic of recruiting endogenous, pharmacologically-mobilized MSCs to degenerative lumbar intervertebral discs. Early results but step in the right direction! 1/ journals.sagepub.com/doi/full/10....

Local RANTES/CCL5 Delivery and Peripheral Blood Mobilization of Endogenous Marrow-Derived Mesenchymal Stem Cells to Mitigate Lumbar Intervertebral Disc Degeneration - Sapan Gandhi, Christopher S. Lai,...

Study Design Translational rodent study. Objectives To investigate (1) chemokine-mediated mesenchymal stem cell mobilization and homing to the intervertebral d...

journals.sagepub.com

Amazing #fishing trip to Northern Ontario with K1 before he moves in @umich.edu next week! 🥹

More miR-awesomeness from @amandality.bsky.social and team in the @hfhs-bjc.bsky.social! Great diagnostic potential for miR's in both #Osteoarthritis and #RheumatoidArthritis.

Henry Ford Bone & Joint Center@hfhs-bjc.bsky.social · last yr.

🚨🚨New publication alert! The Ali Lab @amandality.bsky.social ‬ in the @hfhs-bjc.bsky.social uses sequencing to profile microRNAs in early-stages of both osteoarthritis and rheumatoid arthritis! Now published in Scientific Reports ‪@natureportfolio.nature.com‬, read it here: rdcu.be/eylic

Excited to put this new system to good use, and thankful for the rich history of uCT imaging here @hfhs-bjc.bsky.social from the Yeni Lab. Looking forward to some fun contrast-enhanced imaging of articular cartilage and intervertebral disc! #orthosky

Henry Ford Bone & Joint Center@hfhs-bjc.bsky.social · last yr.

The Henry Ford Health Bone & Joint Center has a storied history with microCT imaging of MSK tissues, thanks primarily to Dr. Yeni's group. Today we took a large leap forward with the installation of a brand new Scanco MicroCT-90 system! #orthopaedics #imaging #bone #cartilage

We got some fishing in on the Huron River yesterday in Ann Arbor after K1 finished new student orientation @umich.edu.

This was a fantastic opportunity to strengthen ties with our @michiganstateu.bsky.social colleagues! Grateful to be able to share our stem cell mobilization work. Many thanks to the Co-Chairs @amandality.bsky.social @mattharkeyphd.bsky.social, Charles Day MD and Jane Manfredi DVM PhD!

Henry Ford Bone & Joint Center@hfhs-bjc.bsky.social · last yr.

Members of the Bone & Joint Center had a great time sharing and learning about musculoskeletal research at @michiganstateu.bsky.social and @henryfordhealth.bsky.social during the HFH+MSU Musculoskeletal Research Retreat. Our Chairman @shouldergeek.bsky.social delivered inspiring opening remarks!

Our paper on enhancing the repair of #RotatorCuff tears using pharmacologic methods to recruit endogenous MSCs is out in AJSM today! The project was fun, but I can't say enough about my amazing co-authors. Read it here: journals.sagepub.com/doi/10.1177/...

Another fantastic @henryfordhealth.bsky.social Research Symposium in the books! Inspiring to hear about all of the awesome research from across the campus. Equally amazing to hear from @boneybonebone.bsky.social of the Yeni Lab @hfhs-bjc.bsky.social talking about facet joint measurement via DTS!

K1 sent pics below of the 🇳🇱 flagged Iver Bright tanker (left) and the 989 ft. M/V American Century diesel-powered freighter (right) while fishing on the St. Clair River.

With the @tigers.bsky.social home opener less than two weeks away, it's time to channel Sparky Anderson. #GrittyTigers #Detroit

Great paper from @boneybonebone.bsky.social of the Yeni Lab in the @hfhs-bjc.bsky.social. DTS could be very useful for understanding facet joint loading associated with spondyloarthropathies, or even new interbody or interspinous spacer devices! #Orthosky #Spine

Henry Ford Bone & Joint Center@hfhs-bjc.bsky.social · last yr.

New paper from Dr. Yeni, @boneybonebone.bsky.social, et al. just published in @jbiomech.bsky.social! The team used digital tomosynthesis (DTS) to quantify spinal facet joint width. They also showed that this technique can be used in vivo to dynamically observe human facet joint loading! #Orthosky

Grateful to be a (very) small part of such an amazing study! All credit to the awesome @amandality.bsky.social and her team for this important #osteoarthritis discovery just published in @naturecomms.bsky.social. The miR-evolution is now!

Amanda Ali@amandality.bsky.social · 2y ago

Excited to share our work on the small but mighty microRNA-126-3p in @naturecomms.bsky.social! We found this microRNA is elevated in four knee osteoarthritis cohorts and show in an animal model that it reduces the severity of knee osteoarthritis - at least in part via angiogenesis. rdcu.be/ebycj

A very Detroit end to day spent helping some neighbors. Spotted this pheasant pair just off Kercheval and Field. (Sorry for the poor quality)

ACL rupture frequently leads to post-traumatic osteoarthritis. We previously showed that ACL rupture disrupts conversion of Tryptophan (Trp) to Kynurenine (Kyn). Injecting IDO-1 into the knee after ACL rupture we restore Trp -> Kyn...and downstream Kyn metabolites! More on these later!

Our folks just sent pictures of the St. Clair River in East China, Michigan. Lots of ice piling up and the CGC Mackinaw cutting a path.

Was great to be back at @michigantech.bsky.social and hanging in the Keweenaw Peninsula again for a few days!

Took advantage of the unseasonable weather today and went fishing with the whole family on the Huron River in Ann Arbor. No fish but plenty of fresh air and sunshine!

Time to get the new printer up and running for the boys!

The 1,013.5 ft. M/V Paul R. Tregurtha was anchored just offshore in East China, Michigan on the St. Clair River today. Longest #freighter on the #GreatLakes!

I love the random, amazing stuff one can find walking around Detroit...like this awesome firetruck in Corktown!