New research just dropped today that makes octopuses even weirder than they already are… let me explain🧵🧪🐙🐡🦑
osn-scott.bsky.social
@osn-scott.bsky.social
Synthetic biologist, passionate about levelling the playing field in bioinnovation - open source biostack. Open Science Network Society, Creator of the Open Yeast Collection and Yeast Protein Expression Toolkit, Reclone.org, iGEM Eng. Team, FreeGenes
🚨TWO YEARS FROM TODAY! 🚨 TOTAL SOLAR ECLIPSE OVER AUS/NZ ☀️🌑🌏 Here's the view 6M+ people in #Sydney will have. Last one here was 1857. Next one here is 2858. It's a once-in-a-thousand-year (totality) event! Are you thinking of coming along to Sydney? A thread of info for you 🧵👇 📸 TimeAndDate
@breakliquid.bsky.social and I are delighted to say our OpenEVO preprint is finally live! An open source hand-made turbidostat that's modular, affordable, and made to be customized. Designed with love for the research community. Enjoy!!!💚 www.biorxiv.org/content/10.6...
OpenEvo: An Open-Source Platform for Automated Evolution and Analysis
Here we introduce OpenEvo, a fully open-source, low-cost turbidostat platform for automated continuous culture and directed evolution experiments. Existing tools are expensive, complex, or lack open-s...
biorxiv.org
I love my lil lab! Sacrificed so much to get here, but I am so damn proud of this research nook that sustains me. The biological equivalent of Carl Sagan's Spaceship of the Imagination. I'm a journeyman helmsman at best, but this little sloop is agile in rough seas.
SPLICECRAFT v1.0 IS LIVE!!!!!!!!!!!! Open your terminal and type in "pipx install splicecraft" if you want to try it out, then spam "splicecraft update" often as I push updates frequently. A labor of love for the community I adore. Enjoy! 💚
PHEW! The last few days were a MARATHON of vibecoding. Got a TON done, still more to go, but I can safely cancel my SnapGene subscription as of today and replace it with my SpliceCraft software for all cloning and genetic design going forward. Exhaustingly tedious but worth it.
Corgi Dog Hacker
ALT: Corgi Dog Hacker
static.klipy.com
Excited to say I'll be releasing version 1.0.0 of SpliceCraft in just 4 days time! It won't be perfect, but I have done as much as I could to bring it to this state and will be open to all criticism on the behavior, utility, errors, etc. Let ego not be the death of good tooling.
Excited to share that my 2025 collection of science-inspired drawings is now live on the Protein Data Bank (PDB) website. Thank you @rcsbpdb.bsky.social! It is free to explore and download. I’d love to hear what you think! pdb101.rcsb.org/sci-art/bezs...
PDB101: Irina Bezsonova Gallery
PDB-101: Training, Outreach, and Education portal of RCSB PDB
pdb101.rcsb.org
Proud of this work with @osn-scott.bsky.social. We challenge the assumption that DNA should be expensive and hard to access. We provide clear steps to making biology more open for strengthening the bioeconomy. 🧬
Canadian Journal of Microbiology@canjmicrobio.bsky.social · 6mo agoInnovation in biotech is bottlenecked by expensive, restricted DNA parts. A new Open Bio Research Alliance could make DNA building accessible, affordable, and open—boosting Canada’s bioeconomy and biosecurity. #SyntheticBiology #OpenScience #Bioeconomy https://ow.ly/pNtW50XW8No
Innovation in biotech is bottlenecked by expensive, restricted DNA parts. A new Open Bio Research Alliance could make DNA building accessible, affordable, and open—boosting Canada’s bioeconomy and biosecurity. #SyntheticBiology #OpenScience #Bioeconomy https://ow.ly/pNtW50XW8No
Excited to share my first PhD project: LabConstrictor 📒🐍 Have you ever created a Jupyter notebook with all your love 🫶, only for others to be unable to install it 🥲? LabConstrictor, comes to solve this! Check out how it works in the preprint 🔗 arxiv.org/abs/2603.107... or follow this thread ⬇️
🚨JOB ALERTS🚨 @flowgenomics.bsky.social in Toronto is hiring a Laboratory and Operations Manager 🧬 and Dr. Yufeng Zhao (University of Toronto) is hiring a Postdoctoral Researcher focused on advancing Organ-on-a-Chip (OOC) models ❤️🩹 www.synbiocanada.org/job-board
Job Board — SynBio Canada
Job Board
synbiocanada.org
Plant assembly in OpenCloning soooooon!
Manuel Lera-Ramirez@manu-lera.bsky.social · 5mo agoSomeone requested #GoldenBraid Assembly, now it's live on #OpenCloning. Still missing the omega Level 1 assembly (coming very soon). For GoldenBraid reference: goldenbraidpro.com and pmc.ncbi.nlm.nih.gov/articles/PMC...
Registration now open for SynBio 8.0, June 15-17 at the University of Waterloo. www.synbiocanada.org/synbio8 Join us at Canada’s premier synthetic biology conference, bringing the community together to showcase advances from across the country and across the full breadth of the field! #synbio8 🍁🧬
Pleased to share the final version of this behemoth of a paper, now finally published. I guess I can retire now? www.nature.com/articles/s41... More functional data, many thousands of words removed, and a few other updates from last year's preprint.
Sequence and chemical specificity define the functional landscape of intrinsically disordered regions - Nature Cell Biology
Langstein-Skora, Schmid, Huth et al. propose that intrinsically disordered region functionality can be driven by the interplay between linear binding motifs and contextual chemical characteristics suc...
nature.com
Alex Holehouse@alexholehouse.bsky.social · 2y agoWe’re pleased to share our substantially updated (more below on that…) version of our manuscript exploring the relationship between conservation in sequence/function for intrinsically disordered regions (IDRs) www.biorxiv.org/content/10.1...
Alliance version 8.3.0 is now live at alliancegenome.org. Release notes are here www.alliancegenome.org/release-notes
Alliance of Genome Resources
alliancegenome.org
I am happy to share my @nature.com News & Views summarizing the recent adjustments to the Global Carbon Budget www.nature.com/articles/d41...
Revised estimates of CO2 sources and sinks improve global carbon accounting
Updated estimates of the worldwide sources and sinks of anthropogenic carbon dioxide provide a firmer basis for monitoring climate action.
nature.com
It’s good to see papers start to address LLMs as structural plagiarism — provenance, more hidden than the original words or training data. www.nature.com/articles/s42...
LLM use in scholarly writing poses a provenance problem
Nature Machine Intelligence - LLM use in scholarly writing poses a provenance problem
nature.com
🚀 A long-requested feature just landed in #OpenCloning 🔬🧬 You can now manually annotate sequences and create primers right from the editor ✨ Hope it makes your workflow a bit smoother! 📨 If you want to stay updated with upcoming features, subscribe to the mailing list (link in the comments)
First time on Bsky and first big announcement! I am excited to announce that our new study explaining the missing heritability of many phenotypes using WGS data from ~347,000 UK Biobank participants has just been published in @Nature. Our manuscript is here: www.nature.com/articles/s41....
Estimation and mapping of the missing heritability of human phenotypes - Nature
WGS data were used from 347,630 individuals with European ancestry in the UK Biobank to obtain high-precision estimates of coding and non-coding rare variant heritability for 34 co...
nature.com
Are you an early-stage graduate student (2nd or 3rd year) or early-stage postdoc based in the US or Canada, working primarily in Drosophila? Would you like to help improve the experience of all trainees working in Drosophila research? If so, read on. (Please repost to reach a broad audience.)
'When Mendel began his investigation, his first inclination was to try breeding mice of different colors. However, before his mice experiment really got going, Mendel was forced to switch the subject of his experiments to peas by a prudish bishop uncomfortable with animals having sex in the abbey.'
Origins of the Lab Mouse
How the mouse found its way from Victorian novelty to a biomedical mainstay.
asimov.press
My former mentor, colleague, and friend Hamilton Smith passed away this week. He was a giant in science, a Nobel Laureate, but also one of the nicest people you could ever meet. He will be missed by many. www.jcvi.org/media-center...
Remembering Hamilton O. Smith
Hamilton O. Smith August 31, 1931 – October 25, 2025 It is with profound sorrow that we announce the loss of Hamilton O. Smith, M.D., a...
jcvi.org
R.I.P Hamilton Smith, 1978 Nobel Laureate for the discovery of type II restriction-modification systems (HindII).
13 years ago, the revolutionary genetic tool #CRISPR/Cas9 was published in Science, work that Emmanuelle Charpentier and Jennifer Doudna won a #NobelPrize for in 2020. On #WorldCRISPRDay, read the landmark paper that describes the discovery: https://scim.ag/42JHuSN
A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunity
A prokaryotic RNA–directed targeting system can be designed to cleave any DNA sequence.
scim.ag
🌎👩🔬 For 15+ years biology has accumulated petabytes (million gigabytes) of🧬DNA sequencing data🧬 from the far reaches of our planet.🦠🍄🌵 Logan now democratizes efficient access to the world’s most comprehensive genetics dataset. Free and open. doi.org/10.1101/2024...
Wow, more than 2.4M of assembled bacteria in the new release of ABT! We plan to index these using our efficient colored De Bruijn graph index, Fulgor. We recently conducted experiments with nearly 1M genomes…getting there :) www.biorxiv.org/content/10.1...
AllTheBacteria - all bacterial genomes assembled, available and searchable
The bacterial sequence data publicly available via the global DNA archives is a vast potential source of information on the evolution of bacteria. However, most of this sequence data is unassembled, o...
biorxiv.org
Related but cool combo of cytogenetics and phenotype. Know when the first QTL was mapped? Sax, K. 1923. The association of size differences with seed coat pattern and pigmentation in Phaseolus vulgaris. Genetics 8:552-560.
A reminder you/your lab can support FlyBase at Cambridge through the following link. Every bit helps. Please share if you yourself can't donate. www.philanthropy.cam.ac.uk/give-to-camb...
Drosophila Genetic Database
The Drosophila Genetic Database, FlyBase, is on the brink of collapse due to the sudden termination of the FlyBase NIH grant, which includes salaries for 5 literature curators based at the University ...
philanthropy.cam.ac.uk
Dr Sian Gramates@drglam.bsky.social · 12mo agoNews via The Transmitter www.thetransmitter.org/community/ha...