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PanakovaLab

@panakovalab.bsky.social

Heart development | heart regeneration | congenital heart disease | imaging | seeing is believing

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Katherine Brown@katherine-brown.bsky.social · last yr.

Big news - I'm going to be moving to a new position at The Company of Biologists, working across all our journals. This means my job is up for grabs! If you're an experienced editor with a love of developmental biology and its community, this could be the role for you. Full details in the link.

biologists.com

Natasha O'Brown@natashaobrown.bsky.social · 2y ago

And somehow I missed it going live last week 😂 - our #zebrafish glial-vascular paper is available for those finterested! One of the best ways to end 2024 as a #newPI www.cell.com/iscience/ful...

Zebrafish glial-vascular interactions progressively expand over the course of brain development

Glial-vascular interactions are critical for the formation and maintenance of brain blood vessels and the blood-brain barrier (BBB) in mammals, but their role in the zebrafish BBB remains unclear. Using three glial gene promoters—gfap, glast, and glastini (a truncated glast)—we explored glial-vascular development in zebrafish. Sparse labeling showed fewer glial-vascular interactions at early stages, with glial coverage and contact area increasing with age. Stable transgenic lines for glast and glastini revealed similar developmental increases, starting at ∼30% coverage at 3 days post-fertilization (dpf) and peaking at ∼60% by 10 dpf, and consistently higher glial coverage in the forebrain and midbrain than in the hindbrain.

cell.com