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Natasha O'Brown

@natashaobrown.bsky.social

Forever developmental biologist at ❤️ studying the blood-brain barrier #BBB in the best model system #zebrafish to understand how different molecular and cellular interactions affect BBB function. www.obrownlab.com

178 Posts3298 Follower2092 Folgt
Natasha O'Brown@natashaobrown.bsky.social · 4w ago

I just used this and filed my formal complaint. As @barrlab.bsky.social said, it was super easy. Just note it needs to be under 5000 characters - boy could I go longer... please if you haven't already, please submit a comment!📝

Maureen Barr@barrlab.bsky.social · last mo.

Posted my comments opposing OMBs proposed rule. It was so easy, using this great letter writing tool of @faseborg.bsky.social www.faseb.org/science-poli... Did you submit yours yet? The deadline is soon - July 13. This is essential to save science and research in the US.

I write in my personal capacity as a research-active faculty member, not on behalf of my institution. I am a distinguished professor at a leading state R1 university. I am also a Senior Principal Investigator whose research laboratory is NIH. I submit these comments in strong opposition to OMB's proposed rule revising 2 C.F.R. Part 200 (Docket OMB-2026-0034). I am requesting that OMB withdraw this rule entirely because of the devasting consequences it will have on biomedical research, human health, the economy, and the nation. The proposed pre-issuance review requirement (§ 200.205) eliminates that independence by giving political appointees – who may have no experience or training in the biomedical research field - veto power over peer-reviewed funding decisions. As a Senior PI / Lab director whose research is supported by NIH, I am deeply concerned that the best science will not be funded, instead politicians will decide not based on merit and research quality, but rather ideology. Peer-review is critical for gold-standard science. This proposed discretionary termination provision (§ 200.340) jeopardizes the future and well-being of the researchers in my laboratory, my department, my university, my state, and the United States. My research program has been continuously funded by the NIH for over two decades. My laboratory is like a small business – with NIH funding, I employ eight full-time personnel. These scientists are at all stages of their careers – newly minted bachelors who are working as research technicians or graduate students; postdoctoral researchers who are completing additional training in order to go onto careers in academia, biotech, industry, governments; senior scientists who have devoted their entire careers to biomedical research and training the next generation of scientists, physicians, dentists, teachers, etc. The proposed international collaboration restrictions (§§ 200.202(e), 200.220) will isolate US scientists and lead to the demise…
Thiago Carvalho@cyrilpedia.bsky.social · 3mo ago

'We primarily do comparative analysis using human stem cells/organoids and genetically modified mouse models, with some minor use of frog models. We use this approach because, for developmental anomalies, it is impossible to assess true function without in vivo models' @karenjliu.bsky.social

Why in vivo models of disease remain indispensable

Summary: The call to arms for alternatives to model organisms of disease will fail without ongoing integration with – and validation against – complex animal models and support from the animal modelli...

journals.biologists.com

Jean Laurens@jeanlaurens.bsky.social · 4mo ago

I created this collection of common brain models in neuroscience, all to scale Across species, brains share fundamental principles and many homologous regions But as size increases, complexity and connectivity change. We need the full spectrum, from flies to rodents, non-human primates, and humans

A scaled collection of brains from common neuroscience model organisms arranged side by side. From left to right: a large human brain and a smaller macaque brain on the top row; below them progressively smaller brains from a marmoset, rat, mouse, zebrafish, and a tiny Drosophila (fruit fly). A coin provides size reference. An inset shows a small, irregularly shaped brain organoid.
Zebrafish Rock!@zebrafishrock.bsky.social · 6mo ago

“Here we developed an experimental-computational platform, WARP, for whole-brain imaging of neuronal activity during behavior, expansion-assisted spatial transcriptomics, and cellular-level registration of these two modalities.” New work from @mishaahrens.bsky.social et al. 🐟 🧠

bioRxiv Neuroscience@biorxiv-neursci.bsky.social · 6mo ago

Whole-Brain Co-Mapping of Gene Expression and NeuronalActivity at Cellular Resolution in Behaving Zebrafish https://www.biorxiv.org/content/10.64898/2026.02.07.704095v1

eLife@elife.bsky.social · 6mo ago

An animal model for cerebral small vessel disease Zebrafish can be used to study the cellular mechanisms responsible for cerebral small vessel disease, which is a leading cause of stroke and dementia. 🔗 buff.ly/wchKmpT

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