Almost 10 years ago - "All biology is computational biology" (2017) - journals.plos.org/plosbiology/... Today - "The total eclipse of bioinformatics: From disruption to convention, and a gentle warning" (2026) - journals.plos.org/ploscompbiol...

All biology is computational biology

Here, I argue that computational thinking and techniques are so central to the quest of understanding life that today all biology is computational biology. Computational biology brings order into our ...

journals.plos.org

Highly under-rated context management for Claude Code ( github.com/lllyasviel/VCC ) and Pi ( github.com/sting8k/pi-vcc ), esp. great with local models. Searchable context is presented as a "UI View" with code chunks replaced with one-line summary pointers like "* Write 'src/pets.py' (.txt:40-62)".

GitHub - lllyasviel/VCC: Compile agent conversations!

Compile agent conversations! Contribute to lllyasviel/VCC development by creating an account on GitHub.

github.com

A beautiful wooden model of pancreatic trypsin inhibitor (5PTI, Wlodawer et al, 1984). From: pmc.ncbi.nlm.nih.gov/articles/PMC...

Big milestone for the AI Protein Design Program last November: our first AI binder design workshop! Proud of the team and grateful to @kmichie.bsky.social for her amazing talk. This is just the beginning… excited for what’s next! #AI #ProteinDesign #AIPDP

This is the first time in a long time I've tried an alternative Python notebook implementation and instantly known I'll switch to using it: docs.marimo.io Batteries included - variable browser, cell dependency tree for automatic reactive updates, a notebook-aware AI chat right there in the sidebar.

marimo

The next generation of Python notebooks

docs.marimo.io