Babis Pappas
@pappasgroup.bsky.social
Phosphates, Chemical Reaction Networks, Self-Assembly https://pappasresearchgroup.com/
Published in #AngewandteChemieNovit: A Review on Acyl Phosphate-Driven Acylation in Biology, Chemistry, and in Between by Lenard Saile & Charalampos G. Pappas. Read it here: doi.org/10.1002/anov...
We are excited to share our cover-featured review in Angewandte Chemie Novit! Fantastic work by Lenard on acylations across biology, chemistry, and in between. Why nature choose acyl phosphates? Coupling reactivity with confinement may hold the answer. onlinelibrary.wiley.com/doi/10.1002/...
We are very happy to share our recent publication in Nature Communications on selection between click and acyl transfer reactions! Congrats to Deb and everyone else involved in the work! www.nature.com/articles/s41...
Happy to share that our work on phosphate leaving groups has been selected as the supplementary cover image for the latest issue of @jacs.acspublications.org Credit to @Ella Maru for the great design. pubs.acs.org/doi/10.1021/ja…
We are happy to share our article, now published in @jacs.acspublications.org !🎉Leaving groups that do not really leave! Congrats to Arti for showing that phosphate leaving groups persist after amide bond formation, affecting the supramolecular properties of the system. pubs.acs.org/doi/10.1021/...
Tailored Phosphate Leaving Groups Direct Pathway-Dependent Self-Assembly
Phosphate esters and anhydrides are central to biology, storing and transferring chemical energy to sustain processes from metabolism to translation. Among them, acyl phosphates are highly reactive, y...
pubs.acs.org
Just out in @ChemRxiv! Switchable amino acyl phosphates! We show how azobenzene-embedded acyl phosphates enable photoperiodic control over non-equilibrium self-assembly. chemrxiv.org/engage/chemr...
Thank you very much @gomobel.bsky.social for highliting our work on @chemistryworld.com. Chiral acyl phosphates meet self-assembly..! Thanks also @claudiabonfio.bsky.social and @jeannecrassousiscr.bsky.social for the very nice comments about our work!!
Fer @gomobel.bsky.social · 10mo agoReally cool stuff by @pappasgroup.bsky.social in @angewandtechemie.bsky.social – chiral chemical fuels drive molecules to self-assemble into different structures, depending on handedness 🧬 My latest for @chemistryworld.com 👉🏼 www.chemistryworld.com/news/chiral-... #ChemSky #RealTimeChem #Chemistry
Just out in @ChemRxiv More than a leaving group!! We show how phosphate leaving groups can regulate reaction pathways and drive orthogonal amide bond formation. Well done Arti! chemrxiv.org/engage/chemr...
Thank you @ella-maru.bsky.social for the great design.
@ella-maru.bsky.social · 10mo ago#SundayCover: Chemical system control itself with a simple handshake! 🤝 The @pappasgroup.bsky.social at @uni-freiburg.de developed a new feedback mechanism for controlling non-equilibrium systems based on chirality.
Just out in @chemrxiv.org Click or Acyl transfer? We show how amino acyl phosphates and peptide nucleophiles direct acyl transfer vs click chemistry, enabling temporal control in abiotic networks. Well done @debjyoti8419.bsky.social chemrxiv.org/engage/chemr...
Happy to see the work from @lenardsaile.bsky.social and Kun Dai highlighted #onTheCover of @angew_chem (inside back cover). Thanks @EllaMaru for the great design. Chiral aminoacyl phosphates!!! onlinelibrary.wiley.com/doi/full/10.... onlinelibrary.wiley.com/doi/10.1002/...
Inside Back Cover: Chirality Makes or Breaks Chemically Driven Self‐Assembly
In their Research Article (e202508481), Lenard Saile and Kun Dai et al. describe a feedback mechanism that controls non-equilibrium systems. Enantiomeric aminoacyl phosphates, depicted as left and ri...
onlinelibrary.wiley.com
We are happy to share that our article on chirality-driven non-equilibrium assembly is published in @angewandtechemie.bsky.social !Congrats to Lenard and Kun for showing how left and right handed aminoacyl phosphates enable control over kinetics and pathways onlinelibrary.wiley.com/doi/10.1002/an…
We are very happy to share our recent publication in @cp-chem.bsky.social on abiotic aminoacylation and side chain recognition through compartmentalization! Congrats to Kun and Lenard, and everyone else involved in the work! www.cell.com/chem/fulltex...
Phase behavior and pathway-selective oligomerization driven by amino acid side-chain recognition
What basic ingredients enable amino acid side-chain recognition and assembly without complex biological machinery? We show that even simple molecular sorters can organize amino acids in space and time...
cell.com
We are looking for a postdoctoral researcher to work on a project funded by the Boehringer Ingelheim Foundation on dynamic peptide self-assembly. 📄 Full position ad: bit.ly/4jAIrmg 📅 Application deadline: May 31, 2025 #Postdoc #ChemistryJobs #SystemsChemistry #AcademicJobs #Freiburg #livMatS
bit.ly
Congratulations Mahesh for successfully defending your thesis! The first PhD student from the group. An amazing research journey ends here and we wish you all the best for your future research adventures!!
Happy for our published article in @NatureComms showing the departure from randomness in peptide bond formation through aminoacyl phosphate esters. Congratulations to Arti and everyone involved.@livMatS_UniFR @UniFreiburg @FreiburgChem @FitFreiburg nature.com/articles/s41...
Selective peptide bond formation via side chain reactivity and self-assembly of abiotic phosphates - Nature Communications
In biological processes, peptide bonds are formed via reactive phosphate-containing intermediates, facilitated by compartmentalized environments. Here, the authors use aminoacyl phosphate esters that ...
nature.com
We have a PhD position on reaction networks driven by aminoacyl phosphate esters funded from @ercresearch.bsky.social at @uni-freiburg.de. Deadline for application is 20/03/25. More information can be found here: static1.squarespace.com/static/5fc39...
