Save the date: The 10th Single Cell Proteomics Conference (SCP2027) will be on July 12 - 14, 2027 single-cell.net/proteomics/s...

Developing treatments for Alzheimer’s and Parkinson’s diseases is limited by the incomplete understanding of the molecular processes underlying them. Single-cell proteomics is opening a new window into these diseases: - It allows for a different type of analysis, different in kind. 1/

We're looking for mass spectrometry enthusiasts who thrive on quantitative rigor, innovation and enjoy challenges: - Colleagues eager to propel biological discoveries by inventing the technologies of the future.

Twenty-four researchers gathered at PTI for a full day of hands-on learning, collaboration, and discovery at the 2026 Single-Cell Proteomics Workshop. Thank you to everyone who joined us and helped make the workshop a success! www.parallelsq.org/blog/2026-si...

My Biemann Medal lecture is now available on YouTube. In it, I trace the exhilarating journey of developing single-cell proteomics, beginning on Christmas Day in 2010, when, as a PhD student, I became convinced that understanding biology would require measuring proteins. youtu.be/z0dIhG4C3qI?...

Biemann Medal Lecture: An exhilarating journey towards single-cell proteomics

YouTube video by Nikolai Slavov

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Since the 1960s, the genetic code has been used to predict protein sequences from DNA and mRNA sequences. Our @nature.com article demonstrates that these predictions miss thousands of protein sequences present in human tissues. www.nature.com/articles/s41... 1/

Nikolai Slavov@slavov-n.bsky.social · 2y ago

We report many proteins not predicted by the genetic code. They are stable & abundant O( 10³ ) copies / cell. Generative mechanisms include codon-anticodon mismatches & RNA modifications. Their abundance depends on codon frequency & protein stability. www.biorxiv.org/content/10.1...

As usually, the Single-Cell Proteomics Conference aims to maximize accessibility. Thus, #SCP2026 will enable virtual attendance via Zoom. It's free but requires registration at single-cell.net Only presentations by speakers who consent to Zoom broadcast will be included in the virtual program.

What are the biggest opportunities in biology today? Understanding the proteome is a huge one. It motivated us to launch @parallelsq.bsky.social: > To increase the sensitivity, scale and resolution for exploring one of biology's most exciting frontiers: youtu.be/9Gz6km1J9Wo?...

The Proteome: Biology's Next Frontier

YouTube video by Nikolai Slavov

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The program for #SCP2026 is online. The talks span diverse technologies and biological questions. Join the discussions, flash talks, and hands-on workshop. 🗓️ July 14-16, 2026 | Boston, USA 🔗 Check out the full program: single-cell.net/proteomics/s...

It's wonderful sharing the journey with a collaborative and thoughtful community. I'm deeply grateful to all who have contributed to the research recognized by the Biemann medal, a very special distinction for research that is gaining momentum. Let's opens new perspectives and explore together !

The annual meeting of the American Society For Mass Spectrometry (@asms.org) has been very special for me as the Biemann Medal recognized our contributions to developing single-cell proteomic technologies and using them to open new perspectives.

The final version of our @annualreviews.bsky.social article is now published OA: www.annualreviews.org/content/jour...

Single-Cell Proteomic Technologies: Tools in the Quest for Principles

Over the last decade, proteomics analysis of single cells by mass spectrometry transitioned from an uncertain possibility to a set of robust and rapidly advancing technologies supporting the accurate ...

annualreviews.org

These numbers are key to understanding RNA and protein analysis. The different counting statistics fundamentally shape technological challenges and opportunities. www.nature.com/articles/s41...

Congratulations to Nikolai Slavov, recipient of the 2026 ASMS Biemann Medal! This award recognizes significant early-career achievement and highlights emerging leaders shaping the future of #massspectrometry. #TeamMassSpec

I am deeply honored to have been selected to receive the Biemann Medal by the American Society For Mass Spectrometry (@asms.org). While this award is presented to an individual, it reflects the collective contributions of exceptional teams at @slavovlab.bsky.social and @parallelsq.bsky.social.

With years of research at its foundation, Nikolai and Harrison highlight the inspiration supporting PTI's own moonshot to make single cell proteomics scalable and accessible for researchers worldwide. Thanks @cowboybearninja.bsky.social for the video! youtu.be/9NNvkJYa43c

Unfolding PTI's Origin Story with Nikolai Slavov and Harrison Specht

YouTube video by Parallel Squared Technology Institute

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This July 14 - 15, the 9th Single-Cell Proteomics Conference (single-cell.net) brings together a community that is redefining what’s possible: Robust methods enable scalable proteoform measurements from single cells without sacrificing depth or quantitative accuracy. 1/3

You can help enable the quantification of thousands of samples/day without sacrificing depth or accuracy. What makes this position special is that these technologies are directly and tightly integrated with biological discovery. 2/2 jobs.lever.co/convergentre...

A special opportunity for lovers of mass spectrometry proteomics to join a like-minded team at PTI. Join a collaborative initiative to enable direct protein analysis at unprecedented scale, in partnership with leading instrument developers, academics, and industry leaders. 1/2

We’re testing conceptual hypotheses, dissecting disease progression, proteostasis, protein degradation, PTMs, and aggregation, all with focus on creative, rigorous data interpretation. If you want to do science that changes how we think, this is it. 👇 jobs.lever.co/convergentre...

🔥 We’re hiring! A rare opportunity to rethink neurodegeneration: 🟦 Develop creative, rigorous approaches to data interpretation toward mechanistic insights. Join our team at PTI to study neurodegenerative disease using direct protein analysis at single-cell resolution. 1/2

During his graduate studies, Mahlon Collins worked with ALS patients who underwent painful spinal taps to donate CSF for his biomarker research. Now, he leads neurodegenerative disease research at @parallelsq.bsky.social. Learn more about Mahlon's journey: bit.ly/3NoKX4g

From patient donations to cellular insights: Mahlon Collins on single-neuron proteomics and the future of Alzheimer’s research

Mahlon Collins leads neurodegenerative disease research at the Parallel Squared Technology Institute (PTI). A neurobiologist by training, he has witnessed firsthand the tremendous burden these disease...

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Single-cell proteomics is moving past descriptive snapshots to quantitative models of cellular regulation and biological mechanisms. Come to #Boston this July to shape the next chapter and have your voice heard. Abstract deadline: Apr 1, 2026. single-cell.net/proteomics/s...

We're delighted to have Mahlon Collins featured in an @ionopticks.bsky.social article! The article goes over Mahlon's work on AD research, with a focus on advancing single-neuron proteomics at PTI. ionopticks.com/2026/01/09/f...

The focussed research organizations enabled by @convergentresearch.bsky.social are driving forward an ambitious agenda ! youtu.be/L5W-lV1K_xQ?...

Convergent Research: A mission control for frontier technology

YouTube video by Convergent Research

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Biology’s earliest decisions are written in proteins. Using single-cell proteomics, we discovered protein (and functional) symmetry breaking in mammalian embryos long before major transcriptome differences are detectable. cell.com/cell/fulltex...

Single-cell proteomics enables discoveries! It illuminates the frontiers of biomedical research.

Slavov Laboratory@slavovlab.bsky.social · 8mo ago

Our latest article is out in Cell ! Together with the Zernicka-Goetz lab, we show that fertilization triggers proteomic asymmetry in mammalian zygotes, giving rise to alpha vs. beta 2-cell blastomeres with distinct developmental potential. cell.com/cell/fulltex...

Among all proteome changes in Alzheimer’s disease (AD), 20S proteasomes stand out. ⬛️ Their abundance strongly declines in AD patients. => This decline parallels a reduction in 20S substrate proteins and leads to abnormal protein accumulation in AD. biorxiv.org/content/10.1...

To facilitate technology dissemination, we will host a workshop in our laboratory. Register to secure a spot! Workshop participation is free with in-person conference registration but requires an advanced registration. To facilitate interactions and hands-on experience, participation is limited.

Nikolai Slavov@slavov-n.bsky.social · 9mo ago

𝗔𝗯𝘀𝘁𝗿𝗮𝗰𝘁 𝘀𝘂𝗯𝗺𝗶𝘀𝘀𝗶𝗼𝗻 𝗶𝘀 𝗼𝗽𝗲𝗻 ! The 9th Single Cell Proteomics Conference (#SCP2026) will take place in #Boston, July 2026. The Single Cell Proteomics Conference focuses on providing opportunities for scientific discussions, interactions and community development. single-cell.net/proteomics/s...

Research Fest highlighted PTI's scientific achievements to date as well as the team that made it all happen. We are thankful for the members on our team and the community who support our work, and wish everyone a Happy Thanksgiving. youtu.be/YFfeJqHC3tM

Panel Discussion with Nikolai Slavov, Harrison Specht, Sarah Sipe, and Kevin McDonnell

YouTube video by Parallel Squared Technology Institute

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