Patrick Kenney, MD MS

@patrickkenney.bsky.social

Med-Peds ID, phage discoverer, more importantly husband and dad. Posts are my own. #medsky #IDsky #askmedpeds #phagetherapy

I played a small role helping set up local protocols for MTb evaluations - happy to see this work continuing to grow! Kutscher, et al, put in significant work - for those who've worked in a BSL3, the work required to complete an animal study, especially the length/complexity for MTb, is Herculean.

Repeated pulmonary dosing of β-glucan-chitosan-PLGA nanoparticles controls Mycobacterium tuberculosis in mice | Antimicrobial Agents and Chemotherapy

Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), remains a leading global health threat. In 2023, TB was responsible for an estimated 1.25 million deaths and once again became the single...

journals.asm.org

We just posted a new preprint describing an anti-MRSA phage targeting the terminal β-GlcNAc on wall teichoic acid. The host becomes phage resistant, but methicillin susceptibility is the consequence in some pathways; cotreatment with methicillin is synergistic at achievable MICs. #phagesky #IDsky

Lytic anti-Staphylococcus aureus phage M963 resensitizes its host to methicillin by a tarS-dependent mechanism

Bacteriophage M963 targeting a clinical strain of methicillin-resistant Staphylococcus aureus (MRSA) was isolated from wastewater. Purification was optimized and the phage was subsequently characteriz...

biorxiv.org

I started studying phages just over 4 years ago. The project that started it all is finally published. We isolated 6 closely related anti-Acinetobacter phages and showed that they are not capsule-specific and can reduce bacterial load in a rat model. More work still to come on this! #phagesky #IDsky

A bacteriophage genus infects carbapenem resistant Acinetobacter baumannii via a non-capsular receptor and provides protection in vivo

Microbiology; Virology

cell.com

If there was any doubt at all that the CDC is fully destroyed, this page on autism and vaccines on its website confirms it. It's now just another vessel of dangerous health misinformation. I have no words. This is beyond sad.

Bild

Glad to see someone is still trying this drug for the US! The FDA declined to approve a few years ago based on (if I remember right) some issues about prespecified endpoints on an otherwise solid trial. I have concerns about overuse, but this could keep people out of hospital and off OPAT. #IDSky

UW Infectious Disease Fellowship Program@uwidfellowship.bsky.social · 12mo ago

GSK’s oral tebipenem phase III study stopped early 2/2 efficacy for cUTI , 58.5% vs 60.2% with IV imi-cil (?!?) for drug-resistant infections. Clinical cure (no sx) 93.5 vs 95.2. FWIW we usually use erta, not imi-cil. Great to have PO option though! #IDWeek #IDSky www.gsk.com/en-gb/media/...

"First do not harm" is not a suggestion it is a core feature of the job. If you can't check your biases at the door when you provide healthcare, find another job. Calling ICE on a patient is some disgusting behavior. www.washingtonpost.com/health/2025/...

Patient seeking care at NIH hospital detained by ICE

NIH officials called immigration authorities after scrutinizing the patient’s identification presented to security at the National Institutes of Health Clinical Center.

washingtonpost.com

New moment of “WTF”: -pt with rare infection (so rare will leave unnamed, as could reveal identity) -nl times: reach out to CDC for testing -now: “they confirmed they are not currently accepting specimens for serology…they suggested we could reach out to Canada National Reference Center” 😳😳😳

Another Recovery paper. I think this one is a victim to earlier success. Study numbers are low, most had vaccine, and most had other antivirals. I don't think you can make any conclusions here. My 2¢ - future studies need to focus on soft outcomes (hospital, ED, etc) or special populations. #IDSky

@id-journal.bsky.social · last yr.

Adding molnupiravir or nirmatrelvir–ritonavir to usual care showed no clinical outcome improvements. Low recruitment limits conclusions, especially for nirmatrelvir–ritonavir. #idsky

All 4 of my NIH research grants are terminated. These were grants on MDR-TB treatment & strategies for supporting adolescents living w/ HIV. This is a massive waste of resources. I am heartbroken for my Harvard team, my partners in Peru, the next generation of scientists & our country. Shame.

🧵1/ With rising STI rates across the U.S., the very programs that protect us were slashed. Cuts to CDC’s Division of STD Prevention gut a system built to stop syphilis, gonorrhea, HIV, and more. Here’s what we’re losing and why it matters to everyone. #IDSky #PublicHealthSky

Where does TrumpElon think innovation for all their favorite biotech corporations comes from? PCR only exists because somebody was looking for bacteria in hot springs at Yellowstone. I’m just a private practice ophthalmologist who barely understands p values but even I know this shit is important.

Rachael Sirianni, PhD@docsirianni.bsky.social · 2y ago

This is my institution. These are the people I work with making these decisions. The situation is heartbreaking. Public medical schools have no other choice; there is no other source of funding, and everyone in academia is at extreme risk right now.

A labor of love, finally in peer review, is up as a preprint. This manuscript describes the first group of phages I isolated and characterized after starting what has become my career research focus. 2+ years of work (during ID fellowship mid-COVID!) in one very long document 😬 #phagesky #IDSky

A Novel Bacteriophage Genus Infects Carbapenem Resistant Acinetobacter Baumannii Via a Non-Capsular Receptor and Provides Protection in Vivo

Extensive drug resistance (XDR) in Acinetobacter baumannii and other pathogens has revitalized bacteriophage as a therapeutic consideration. Six phages (AB1I1L,

papers.ssrn.com

Rubio terminated 5800 USAID contracts – more than 90% of its foreign aid programs – in defiance of the courts. Here’s a list of just some of the lifesaving awards that were terminated. Nearly all were Congressionally mandated. They’ve saved millions of lives. 🧵