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Paula Tirado

@paulatiradom.bsky.social

Biologist 🧬| PhD researcher at @InstitutoCajal 🧠🔬 Adult and developmental neurogenesis in the hippocampus

11 Posts60 Follower139 Folgt
Paula Tirado@paulatiradom.bsky.social · last yr.

So happy to see this one finally out! Have a read if you are interested in adult neurogenesis and neural development ✨🧠🧪

Aixa V. Morales@aixa-v-morales.bsky.social · last yr.

Ever wondered how adult #NeuralStemCells develop and acquire their lifelong potential? Excited to share our latest work on the origin of #AdultNeurogenesis by Cris Medina @paulatiradom.bsky.social Lingling Li & @pilar-rguezm.bsky.social now in @plosbiology.org🧪🧠 @institutocajal.bsky.social 👇🧵

New neurons are generated throughout adult life in the adult neurogenic niche in the hippocampus through activation of reversibly quiescent neural stem cells (NSCs). The cover highlights DCX+ immature neurons (blue) in the hippocampal dentate gyrus of a conditional mutant mouse for Sox5, with recombined Sox5 deficient cells in magenta. Medina-Menéndez et al. report that Sox5 is required to control the correct establishment of quiescence during the first postnatal weeks of dentate gyrus development, which is essential for establishing long-lasting adult neurogenesis. https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3002654
Aixa V. Morales@aixa-v-morales.bsky.social · last yr.

Our new work on the establishment of quiescence in #adultneurogenesis , done at @institutocajal.bsky.social @csic.es, is out in @plosbiology.org . Proud of a Great team, Cristina Medina, @paulatiradom.bsky.social , Lingling Li , @pilar-rguezm.bsky.social and the rest ! 🎊🎉🧠

PLOS Biology@plosbiology.org · last yr.

Quiescent hippocampal #NeuralStemCells (NSCs) support #neurogenesis in adulthood. @aixa-v-morales.bsky.social &co show that NSCs have different levels of quiescence & that Sox5 controls the balance between shallow & deep quiescence during hippocampal development @plosbiology.org 🧪 plos.io/44Su34u

Top: DCX+ immature neurons (blue) in the hippocampal dentate gyrus of a conditional mutant mouse for Sox5, with recombined Sox5 deficient cells in magenta. Image credit: Cristina Medina-Menéndez. Bottom: Summary of NSC quiescence dynamics during early postnatal DG development (left) and their alterations in Sox5null mice (right).
Pilar Rodríguez 🧠🐁@pilar-rguezm.bsky.social · last yr.

💥 We are very proud of our last paper now plublished in @plosbiology.org ! Really thorough study of how NSCs acquire quiescence during early postnatal stages by @aixa-v-morales.bsky.social lab. Great job @paulatiradom.bsky.social 💪. Congrats!

PLOS Biology@plosbiology.org · last yr.

Quiescent hippocampal #NeuralStemCells (NSCs) support #neurogenesis in adulthood. @aixa-v-morales.bsky.social &co show that NSCs have different levels of quiescence & that Sox5 controls the balance between shallow & deep quiescence during hippocampal development @plosbiology.org 🧪 plos.io/44Su34u

Top: DCX+ immature neurons (blue) in the hippocampal dentate gyrus of a conditional mutant mouse for Sox5, with recombined Sox5 deficient cells in magenta. Image credit: Cristina Medina-Menéndez. Bottom: Summary of NSC quiescence dynamics during early postnatal DG development (left) and their alterations in Sox5null mice (right).
Pilar Rodríguez 🧠🐁@pilar-rguezm.bsky.social · 2y ago

En un #28F de hace 2 años escribí un pequeño hilo en Twitter para hablar de una enfermedad rara que, cada día, lo es un poco menos: el síndrome de Lamb-Shaffer. ¿Os parece si hacemos un poco de mudanza y me lo traigo a Bluesky? 📦 ⬇️ Aquí viene un poco de copia-pega