Back from #ESM2026 in Verona, grateful and proud. Two of my research contributions, co-authored with Mireia @pathogenomics.bsky.social, were presented. Honoured to receive the Travel Award and Best Oral Presentation. Thank you, Mireia, for your guidance and support. @i2sysbio.es @esmyco.bsky.social

Sempre atent amb els usuaris, el primer dia de les PAU #metrovalencia ofereix el seu exclusiu tram-llauna de sardines per accedir al campus de Burjassot-Paterna de la @uv.es

Nextstrain #ANDV trees updated with a few improvements: - 2 outbreaks marked - host scientific/common name added - province now visible on map - date colouring added Here's a quick tour of how to change colours, geography & names! Links to trees here (scroll down): nextstrain.org/groups/hodcr...

📢 Abstract deadline extended! Submit your abstract for the ESM Annual Congress 2026 by 10 May 2026 final deadline. Share your research, case studies & innovations in mycobacteriology. Submit/register: www.esmycobacteriology.eu/event-regist... #Mycobacteriology #ESM2026

Metabuli & Metabuli App v1.2 improve novel species classification with higher precision and recall. New light mode is 1.8× faster and requires 50% less storage while keeping precision. New RefSeq, GTDB, HRGM, and HROM databases added. 💾 github.com/steineggerla... 📄 doi.org/10.64898/2026.03.13.711249

Really excited to be able to share our latest preprint, describing how during its evolution in cattle, H5N1 has got better at using a type of alternative receptor that's abundant in cows, but not found in humans and birds. www.biorxiv.org/content/10.6...

🧬 pathotypr is now on Bioconda! @pathogenomics.bsky.social conda install -c bioconda pathotypr Alignment-free lineage classification & drug resistance genotyping from WGS. Works with any pathogen bring your own SNP markers. ⚡ Rust, ~1s/sample 🖥️ CLI + GUI 🔗 github.com/PathoGenOmics-Lab/pathotypr

New paper from Hugh Cottingham, @katholt.bsky.social , @yekwah.bsky.social @nenadmacesic.bsky.social and co. Great to see the speed/accuracy tradeoff info here, I don't think I've seen it laid out like this before. www.microbiologyresearch.org/content/jour...

💥Our latest @embojournal.org on membrane damage and repair. Di @dichen02.bsky.social @crick.ac.uk found that calcium is a conserved signal for ATG8/LC3 lipidation on membranes using novel probes to record calcium leakage. Congratulations Di et al! link.springer.com/article/10.1...

Ca²⁺ leakage is a conserved signal for non-canonical ATG8/LC3 lipidation and membrane repair - The EMBO Journal

Endomembrane damage of intracellular vesicles triggers signals that activate membrane repair in mammalian cells to restore homeostasis. However, the signals that drive diverse membrane repair recruitm...

link.springer.com

metode.cat/revistes-met... Una magnífica exposició de @martidominguez.bsky.social per al @museuciencies.cat

El món vegetal de Darwin - Revista Mètode

«Darwin Botànic» és el títol de l’exposició que el Museu de Ciències Naturals de Barcelona ha instal·lat en l’Hivernacle del parc de la Ciutadella. El subtítol «Les plantes com a evidència de l’evoluc...

metode.cat

Pathotypr: harmonised MTBC lineage assignment and resistance-associated variant detection for genomic surveillance https://www.biorxiv.org/content/10.64898/2026.03.24.714002v1

Pathotypr: harmonised MTBC lineage assignment and resistance-associated variant detection for genomic surveillance https://www.biorxiv.org/content/10.64898/2026.03.24.714002v1

In benchmarking, Pathotypr showed very high concordance with phylogenetic lineage assignment and achieved very fast analysis speeds, making near real-time TB genomic surveillance feasible even on standard desktop hardware. It is available as both a command-line tool and an easy desktop GUI.

The toolkit integrates multiple modules in one workflow: Train / Predict for lineage classification, Split FASTQ / Classify for genotyping from reads or assemblies, and Match Ref to identify the closest reference genome for each sample.

Pathotypr supports all 14 currently recognised MTBC lineages, including human-adapted lineages L1-L10 and animal-adapted clades A1-A4. It also incorporates recently described diversity such as L10, helping standardise TB genomic surveillance across settings.

Excited to share Pathotypr with @paururo.bsky.social, our open-source toolkit for rapid, harmonised MTBC lineage assignment and drug-resistance genotyping from both genome assemblies and raw reads. @i2sysbio.es. tool github.com/PathoGenOmic.... preprint: doi.org/10.64898/202...

GitHub - PathoGenOmics-Lab/pathotypr: Genome classificator using machine learning and SNP markers.

Genome classificator using machine learning and SNP markers. - PathoGenOmics-Lab/pathotypr

github.com

🔬 Hoy es el Día Mundial de la Tuberculosis. Esta imagen refleja algo que rara vez se ve: las horas dentro de un BSL-3, la bioseguridad, el trabajo silencioso detrás de cada avance. @i2sysbio.es @pathogenomics.bsky.social

World TB Day 2026. TB is still a major public health challenge in Europe: 19,000 deaths, 204,000 cases, and up to 55,000 drug-resistant TB cases in 2024. ESM calls for stronger research, surveillance, and equitable access to diagnosis, treatment, and prevention. #WorldTBDay #TB

Researchers from the PathoGenOmics Lab @pathogenomics.bsky.social in #I2SysBio work daily to combat transmission of M. tuberculosis through genomics #microsky #WorldTBDay #Tuberculosis

PathoGenOmics Lab@pathogenomics.bsky.social · 4mo ago

🔬 World TB Day 2026 — Behind the mask, inside BSL-3. Our team works daily to understand M. tuberculosis evolution, resistance & transmission through genomics. TB still kills 1.25M people/year. Research matters. @i2sysbio.es #WorldTBDay #EndTB #Tuberculosis

🔬 World TB Day 2026 — Behind the mask, inside BSL-3. Our team works daily to understand M. tuberculosis evolution, resistance & transmission through genomics. TB still kills 1.25M people/year. Research matters. @i2sysbio.es #WorldTBDay #EndTB #Tuberculosis

You can now view a tree of 2,399,238 bacterial genomes we made from AllTheBacteria (on the great Taxonium): taxonium.org/atb That's a big tree! (unless you're used to SC2 trees)

Final version of our last paper is out! www.nature.com/articles/s41...

Plasmids promote antimicrobial resistance through insertion sequence-mediated gene inactivation - Nature Microbiology

Inactivation of chromosomal genes through plasmid-encoded IS elements is an extended mechanism of antimicrobial resistance evolution in bacteria.

nature.com

El Instituto de Biología Integrativa de Sistemas celebra su décimo aniversario con un acto conmemorativo en el Parc Científic de la Universitat de València www.i2sysbio.es/communicatio... @i2sysbio.es

Happy Bioinformatics Day!🧬💻Celebrate the power of data for understanding life at every level. In @pathogenomics.bsky.social we combine experiments with bioinformatics to understand bacterial evolution, virulence, and infection dynamics. #SoyBioinformatica @paururo.bsky.social @ahmig.es @i2sysbio.es

Proud to celebrate 10th anniversary of @i2sysbio.es 🎉 Being part of a community dedicated to discovery, collaboration, and advancing science is truly inspiring. Grateful to contribute, learn, and grow alongside such passionate colleagues. Here’s to many more years of knwledge and impact! 🔬✨

I made a map of 3.4 million Bluesky users - see if you can find yourself! bluesky-map.theo.io I've seen some similar projects, but IMO this seems to better capture some of the fine-grained detail

Bluesky Map

Interactive map of 3.4 million Bluesky users, visualised by their follower pattern.

bluesky-map.theo.io

¿Quieres un impulso a tu formacion investigadora🔬? En @i2sysbio.es ofertamos beca JAE Intro @amrhubcsic.bsky.social al. Plan formativo "Frenar la adquisición de resistencia en bacterias patógenas💊". 6 meses remuneración de 600 €/mes. Aplica antes del 10 marzo en www.convocatorias.csic.es/convoca/

🚀 #ESM2026 registration is open! 46th Annual Congress of the European Society of Mycobacteriology. 📍 Verona, Italy | 🗓️ 22–25 June 2026 🔗 www.esmycobacteriology.eu/event-home

get_mnv v1.0.1 🧬 It turns multiple SNVs in the same codon into true MNVs, so your protein impact annotation is correct. v1.0.1 adds GFF3 + multi-sample VCF support, bgzip/Tabix + BCF output, and reproducible JSON summaries/manifests. github.com/PathoGenOmic... @i2sysbio.es @pathogenomics.bsky.social

Release 1.0.1 · PathoGenOmics-Lab/get_MNV

Added --gff support for gene annotation (GFF/GFF3). --chrom support for selecting one or multiple contigs. --sample support for selecting a sample in multi-sample VCFs. --strict validation mode fo...

github.com

Bien. Ahora, imaginad: si nosotros con un orden de magnitud menos de pasta somos capaces de sacar trabajos equivalentes, ¿que pasaría si se invirtiera en los que ya estamos aquí?

Jorge Chacártegui@jchacartegui.bsky.social · 6mo ago

Pescando en río revuelto americano para llevarse selebros. www.lamoncloa.gob.es/serviciosdep...