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New in @bmc.springernature.com: "In this nationally representative sample of U.S. children and adolescents, a higher LCD score was associated with increased odds of obesity." #pediatrics #lowcarb #obesity #protein #highprotein link.springer.com/article/10.1...

Association between low-carbohydrate diet score and childhood obesity: a national population-based study - BMC Pediatrics

Background Aimed to investigate the association between a low-carbohydrate diets (LCD) score and the prevalence of obesity in a large, nationally representative sample of children and adolescents in the United States. Methods This cross-sectional study utilized data from participants aged 2–17 years from the National Health and Nutrition Examination Survey (NHANES) spanning 2003 to 2018. The exposure of interest was an LCD score, calculated based on the relative intake of carbohydrates, proteins, and fats from the mean of two 24-hour dietary recalls. The primary outcome was obesity, defined as a body mass index at or above the 95th percentile for age and sex. Multivariable logistic regression analysis with three progressive models, restricted cubic spline (RCS) analysis, and subgroup analyses were performed. Results A total of 12,684 participants were included in the final analysis, including 7,392 with obesity and 11,679 without obesity. After comprehensive adjustment for demographic, socioeconomic, and dietary covariates (including total energy intake), a higher LCD score was positively associated with the odds of obesity. When treated as a continuous variable, each one-unit increase in the LCD score corresponded to a 2% increase in the odds of obesity (OR = 1.02, 95% CI: 1.01–1.03, P < 0.001). When categorized into quartiles, participants in the highest quartile (Q4) had 40% higher odds of obesity compared to those in the lowest quartile (Q1) (OR = 1.40, 95% CI: 1.17–1.68, P < 0.001). The RCS analysis confirmed a significant non-linear association between the LCD score and the odds of obesity (P for non-linearity = 0.001). Furthermore, subgroup analyses indicated that the association varied across strata; for instance, a significant positive association was observed in children aged 12 years and younger but not in older adolescents, and was stronger in males than in females, though formal tests for interaction were not statistically significant. Conclusion In this nationally representative sample of U.S. children and adolescents, a higher LCD score was associated with increased odds of obesity. This finding suggests that a dietary pattern characterized by a lower proportion of carbohydrates and higher proportions of fat and protein may reflect poor overall dietary quality rather than a structured, health-promoting diet, which is associated with higher obesity prevalence. Clinical trial number Not applicable.

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New in @bmc.springernature.com: "Our findings indicate that maternal diets – such as those high in animal-sourced protein and fat and low in dietary fibre – are of elevated risk for GDM."🥦 #diabetes #type2diabetes #lowcarb #pregnancy #plantbased link.springer.com/article/10.1...

Maternal macronutrient intake and gestational diabetes: systematic review of prospective observational studies and dose-response meta-analyses - BMC Medicine

Background Gestational diabetes mellitus (GDM) is a common pregnancy complication associated with markedly elevated risk of type-2 diabetes in later life. Pregnancy or pre-pregnancy diet is a likely risk factor for GDM, with macronutrients—including proteins, fats, carbohydrates, and alcohol—being the primary dietary components to influence risk. In this study, we have conducted a systematic review and meta-analyses of pregnancy or pre-pregnancy dietary macronutrient intakes, including by source and type, on GDM occurrence to better elucidate the role of maternal diet on GDM. Methods We ran an online search on 15 August 2025 in OVID Medline, EMBASE, and EBM Reviews, augmented with reference searching to identify prospective observational studies reporting pregnancy or pre-pregnancy dietary intakes and GDM incidence. Screening, data extraction, and risk of bias assessment using the Newcastle–Ottawa Scale were performed by at least two reviewers. Macronutrient exposures and GDM incidence were considered with random effects higher versus lower (HvL) and dose-response analyses. Certainty of evidence was then considered with GRADE to comment on maternal macronutrient intakes and GDM. Results From 3990 initial titles, we identified 25 prospective observational studies of 115,496 pregnant women reporting at least one macronutrient intake and GDM. There was moderate certainty evidence that animal-sourced protein (HvL: RR 1.62 (95% CI 1.20 to 2.18) I2 82%) and animal-sourced fat (HvL: RR 1.59 (95% CI 1.34 to 1.88) I2 0%) intakes were associated with higher GDM in a dose-response manner. Total protein (HvL: RR 1.63 (95% CI 1.22 to 2.18) I2 64%) and vegetable fat (HvL: RR 1.25 (95% CI 1.06 to 1.47) I2 0%) showed positive associations with outcome in HvL but without dose response, while dietary fiber (HvL: RR 0.65 (95% CI 0.44 to 0.96) I2 89%) was the only macronutrient to indicate a protective effect against GDM with higher intakes in a dose-response manner, with moderate certainty evidence. Conclusions This study is the first to consider maternal intake of all macronutrients, including by source and type, on GDM occurrence. Our findings are largely in line with healthy dietary advice for the general population (promoting high fiber and low animal-sourced fat intakes); however, higher protein intakes (both total and animal-sourced) may be a specific concern that is not currently considered in dietary guidance during pregnancy, requiring further research. Trial registration PROSPERO (CRD420251001515).

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