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@peterwlaird.bsky.social

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Jesse Boehm@boehmjesse.bsky.social · 12h ago

Hot off the press in Nature! After 10 years, 2,780 patients and 300+ scientists, today we announce the Human Cancer Models Initiative (HCMI) release of 665 organoids and other next generation models! All models and data available to accelerate cancer drug discovery! @nature.com rdcu.be/fx3I3

A compendium of next-generation patient-derived models for diverse cancers

Nature - The international collaboration of the Human Cancer Models Initiative presents a comprehensive resource of next-generation cancer models from 2,780 donors with 25 cancer types and...

rdcu.be

@peterwlaird.bsky.social · last yr.

Our paper on deep single-cell DNA methylation analysis is out in Nature Communications rdcu.be/evfJm. Super elegant work by Nathan Spix describing replication dynamics, X-inactivation, and cell lineage identification.

High-coverage allele-resolved single-cell DNA methylation profiling reveals cell lineage, X-inactivation state, and replication dynamics

Nature Communications - Here, the authors describe scDEEP-mC, an improved single-cell whole-genome bisulfite sequencing method for complex libraries and deep genomic coverage, and show advanced...

rdcu.be

John Greally@greally.bsky.social · last yr.

I can't believe we're still allowing completely inadequate and uninterpretable Epigenome-Wide Association Studies (EWAS) to be published. I don't care that this study is probably well-intentioned, and probably trying to draw attention to awful events in Syria. www.nature.com/articles/s41...

Epigenetic signatures of intergenerational exposure to violence in three generations of Syrian refugees - Scientific Reports

Scientific Reports - Epigenetic signatures of intergenerational exposure to violence in three generations of Syrian refugees

nature.com

American Association for Cancer Research (AACR)@theaacr.bsky.social · last yr.

AACR urges Congress to reaffirm its long history of steadfast and bipartisan support for medical research by ensuring that NIH has all of the resources needed to advance its lifesaving mission to prevent, diagnose, and treat cancer and other diseases: AACR.org/NIH

AACR Legislative Action Center

Directly contact your elected officials about the importance of cancer research, the need for continued funding and the latest lifesaving breakthroughs. In the United States, you can do so by sending ...

aacr.org

American Association for Cancer Research (AACR)@theaacr.bsky.social · last yr.

The AACR is deeply concerned that the Administration’s recent actions are threatening NIH and its mission to accelerate progress for patients with cancer and other diseases that afflict millions of Americans. Read our statement: https://buff.ly/4gRXNB8

Fyodor Urnov@urnov.bsky.social · last yr.

In Stalin's USSR geneticists were, for political reasons, labelled "fly lovers who hate people" (мухолюбы-человеконенавистники). Soviet genetics died as a field. A complementary way to kill biomedical research that yields lifesaving medicines is to defund it for equally political reasons:

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@andrewpospisilik.bsky.social · 2y ago

Wondering whether your cancer risk might start before you are born? Our latest work published in #Nature Cancer suggests it does, through regulation by Trim28 and #epigenetic silencing. Congratulations to @ilariapanzeri.bsky.social for spearheading! Read it here: www.nature.com/articles/s43...

TRIM28-dependent developmental heterogeneity determines cancer susceptibility through distinct epigenetic states - Nature Cancer

Panzeri et al. use a Trim28+/D9 mouse model with intrinsic developmental heterogeneity to show that ‘heavy’ and ‘light’ developmental morphs exhibit different timing, type and severity of cancer, link...

nature.com

Duncan Sproul@sproullab.bsky.social · 2y ago

New pre-print alert 🚨 Interested in what @ikafetzo.bsky.social learned about DNA hypomethylation in cancer from investigating surprising gains DNA methylation in DNMT1 KO cells? Read all about it here: www.biorxiv.org/content/10.1... For a quick summary see this 🧵 1/8 #epigenetics

DNMT1 loss leads to hypermethylation of a subset of late replicating domains by DNMT3A

Loss of DNA methylation is a hallmark of cancer that is proposed to promote carcinogenesis through gene expression alterations, retrotransposon activation and induction of genomic instability. Cancer-...

biorxiv.org

@peterwlaird.bsky.social · 2y ago

Thrilled to share the results in Cancer Cell of years of hard work to develop classifiers for all major TCGA cancer subtypes, enabling assessment of differential drug response among cancer subtypes in clinical trials. www.cell.com/cancer-cell/...

Classification of non-TCGA cancer samples to TCGA molecular subtypes using compact feature sets

Ellrott et al. provide a means to assign patient samples from clinical trials and other cancer genome studies to published TCGA molecular subtypes. Applying machine learning to data from five different molecular platforms for 8,791 TCGA tumor samples, they contribute a public resource of 737 top classifier models, which can form the foundation for clinical assay development.

cell.com

Van Andel Institute (VAI)@vai.org · 2y ago

Congratulations to VAI's Dr. Russell Jones and Dr. @peterwlaird.bsky.social for being named to this year's Clarivate Highly Cited Researchers list — a distinction that marks them as leaders in their fields. #HighlyCited2024

Van Andel Institute scientists named to prestigious Highly Cited Researchers list – Van Andel Institute

VAI scientists Russell Jones, Ph.D., and Peter W. Laird, Ph.D., are included in this year’s Clarivate Highly Cited Researchers list, a distinction marking them as leaders in their fields.

vai.org