Our award-winning, NYTimes Critics’ Pick film, HUMAN NATURE, is now free for K-12 classrooms! It explores the science, ethics, and human impact of #CRISPR. Deemed “essential viewing” by Nobel laureate Jennifer Doudna. ▶️ bit.ly/humannatureedu #ScienceEducation #STEMEd #K12Education

After 30 min on "nano banana" in Gemini-3 I would like to know: does BioRender have a future for plain vanilla scientific schematics? I got LLM instructions for how to write the prompt for the image below and 1.1 sec later ...

PSA: this prompt in Gemini-3 takes a zoom transcript with 12 participants and 90 min of technical discussion and in 0.5 sec converts it into 28 pages of flawlessly formatted, clearly legible, zero-reduction-of-dataset-dimensionality text. There are MANY reasons to be concerned about AI - but wow ...

Out now in the The Atlantic — IGI's Jennifer Doudna and Fyodor Urnov on this year's remarkable progress in using #CRISPR to treat rare diseases. Read here: https://ow.ly/5vJ750XFQon

🎙️ON AIR: Startups want to make genetically engineered babies. We talk to @innovativegenomics.bsky.social's @urnov.bsky.social, @wsj.com's @klong.bsky.social and Center for Genetics and Society's Katie Hasson about what's at stake. ❓Would you support genetically engineering embryos? 📻 Listen:

Bay Area Startups Want to Make Genetically Engineered Babies. What Could Go Wrong? | KQED

We’ll talk to experts about how innovations in genetic engineering are being directed what is at stake.

buff.ly

With the important exception of folks from Denmark - to whom this unfortunately does not apply, undskyld - this is 8 min of pure ristretto-grade joy. (oh and if you like football / soccer, the goals are phenomenal) www.youtube.com/watch?v=z8qF...

🎙️ ICONIC Radio Commentary | Scotland v Denmark | Scotland National Team

YouTube video by Scotland National Team

youtube.com

Every single person working today in every branch of cell and gene therapy - viral, nonviral, editing, transgenesis - owes a deep debt of gratitude to Dr. High.

Eric Topol@erictopol.bsky.social · 9mo ago

“I had hemophilia for nearly five decades. I went to Philadelphia and had a 45-minute infusion, and my hemophilia was gone.” Genes-> Medicine nature.com/articles/s41...

Holy mother of my personal lord Gregor Mendel. We now have WHAT?!?

Maddy Seale@maddyseale.bsky.social · 9mo ago

And now we have Arabidopsis plants with 8 chromosomes instead of 10 and no obvious phenotypic differences, this week in @science.org #PlantScience Paper here: www.science.org/doi/10.1126/... Perspective here: www.science.org/doi/10.1126/...

Re ChatGPT in college ed. I first GSIed in 1991 at Brown and joined Berkeley faculty in 2000 - 50 semesters of teaching upper-div. The "conversations" I've had w the LLM about areas I teach in blow me away. Fellow faculty - specifically for upper-div bio we may be obsolete soon. Don't at me. Try it.

I need to understand how Marco managed to get a camera in front of my car. (those very few of you who do not understand what this is about - enjoy every second of that unique state)

Marco Trizzino@marcotrizzino.bsky.social · 9mo ago

Current situation in my household (we have a 6 year old girl)

It's Saturday. With that. I am forced to watch a 35 min UC video about cybersecurity and it's a stunning phenocopy of what, IMHO, is the single best TV comedy work from the UK (other than the Python TV series and FT). Give it a shot. Its joys unfold slowly. www.youtube.com/watch?v=FBaV...

Look Around You: Season 1 Pilot - Calcium

YouTube video by DocShadow660

youtube.com

How incredibly gracious and sweet they named the vehicle "Doc Ricketts." "Canary Row" is one of my favorite books of all time and this story warmed my heart. Plus the fish is totes adorbs. www.nytimes.com/2025/09/08/s...

A New, ‘Adorable’ Deep-Sea Fish Swims Into View

nytimes.com

Of David's countless accomplishments is the important work that Matt Porteus did in his lab on early-stage genome editing with engineered nucleases (pubmed 12730593). He and Matt both speak about this in the documentary "Human Nature." A true titan. www.nytimes.com/2025/09/07/s...

David Baltimore, Nobel-Winning Molecular Biologist, Dies at 87

nytimes.com

If only, if ONLY there was some method to change these newly discovered TF binding "motifs" at endogenous gene regulatory regions to see if ANY of this new phenomenology has ANYTHING to do with actual gene regulation... 1. PHE PHE SER. 2. SER MET HIS. www.nature.com/articles/s41...

Multiple overlapping binding sites determine transcription factor occupancy - Nature

A new method enables comprehensive screening and identification of low-affinity DNA binding sites for transcription factors, and reveals that nucleotides flanking high-affinity binding sites create ov...

nature.com

"Epigenetics: the way genes learn from experience" (Mikula BC, Genetics 140-379; 1985). Here it is, folks - an atlas of human genes learning from experience. Holy Waddington. www.researchsquare.com/article/rs-7...

In Brief: A new center in San Francisco will offer tailor-made CRISPR therapies to cure children with rare diseases www.nature.com/articles/s41...

Fellow editors - nota bene 10x!

Griffiths Lab@griffithslab.bsky.social · last yr.

Sometimes, knocking out a gene isn't a good way to figure out the function of that gene ... In our new @jcellsci.bsky.social paper, we report potent transcriptional adaptation by cytotoxic T lymphocytes (CTLs) in response to CRISPR/Cas9-mediated deletion of the important polarity protein CDC42 🧵⬇️

PSA: if you're not a mouse person you may enjoy knowing that mouse Sca1 (the hematopoiesis marker) is not encoded by Sca1 (spinocerebellar ataxia 1) but rather Ly6a. I mean, OF COURSE it is. What else could it be? I'm an hg38 person and below is a self-portrait while I was figuring this out.

F1.1 (Taz Urnov) acquired and edited this gem for Soho Press. www.npr.org/2025/08/13/n...

A dogged reporter takes on a mysterious cabal in 'The Diary of Lies'

Philip Miller's sinister thriller is set in a Great Britain that's lost its bearings. But even when she's terrified, fictional journalist Shona Sandison will always risk everything to get the story.

npr.org

A new CRISPR Cures center, fuded by $20M from @chanzuckerberg.bsky.social and led by @urnov.bsky.social, will create 8 custom therapies for patients in the next 3 years. “Our goal is to aggressively walk the walk of CRISPR platformization,” Urnov told me. @endpts.com endpoints.news/crispr-cures...

'CRISPR Cures' center launches with $20M to make customized gene editing therapies

Scientists seeking to make personalized gene editing therapies a reality for more people have launched a new initiative to develop cures for the rarest of diseases left behind by drug companies.

endpoints.news

"Quaternary kissing loops"👌

Korostelev Lab@korostelevlab.bsky.social · last yr.

With our ‪@RTI-UMassChan.bsky.social‬ colleagues Xiaobin Ling and Wenwen Fang, we report cryo-EM structures of enigmatic bacterial RNA nanocages made of ROOL RNAs. Octamers are held by "A-minor staples" and other interactions. Congrats Xiaobin, Dima et al! www.nature.com/articles/s41...

Thanks to the BBC's The Inquiry program for great conversations with IGI's @jenniferdoudna.bsky.social @doudna-lab.bsky.social and @urnov.bsky.social about Baby KJ, #CRISPR on-demand, and the future of personalized medicine! Listen here: www.bbc.com/audio/play/w... Photo credit: TODAY

Paul Wade was my patient and gracious mentor in Alan Wolffe’s lab (‘97-99). He did gorgeous work back then and continues to do so.

Jackson Hoffman@jxhoffman.bsky.social · last yr.

Congrats on the new paper to Krystal who "doesn't do social media" but does do a ton of ATAC and Cut&Run to show how GATA3 pioneers enhancers with BRG1 and sometimes AP-1! #NIEHS #NAR doi.org/10.1093/nar/...

IGI's @urnov.bsky.social today at the #FDA Roundtable on Cell & Gene Therapy. Grateful for an opportunity to share more about using #CRISPR on demand to treat rare diseases! Watch here: www.youtube.com/watch?v=0qDh... 🧬

FDA Roundtable on Cell and Gene Therapy

YouTube video by U.S. Food and Drug Administration

youtube.com

I have written a concerto for it. phys.org/news/2025-06...

Physicists create 'the world's smallest violin' using nanotechnology

Physicists at Loughborough University have used cutting-edge nanotechnology to create what they believe may be "the world's smallest violin," which is small enough to fit within the width of a human h...

phys.org

Here: Baby KJ at home with his mom Nicole. This really happened, folks. Hundreds of people from 8 organizations (led by Rebecca Ahrens-nicklas and Kiran Musunuru) came together to make a bespoke gene editor for this kiddo. He was once in the 7th percentile of body weight. Look at him now! ❤️

I watch my original field - chromatin and gene control - from a distance. The literature showing that so-called higher-order chromatin organization appears to have no substantial effect on gene expression grows and grows. Which is not stalling the scholars of that organization. :-) :-) :-)

It's Sunday. With that. Soccer postulate #1: score more goals than your opponent. Postulate #2: if you are a goalie and Messi is on the opposing team, do not pass the ball to Messi. www.youtube.com/watch?v=Au3H...

MESSI BREAKS INTER MIAMI GOAL RECORD 🚨 Inter Miami vs. Columbus Crew | MLS Highlights | ESPN FC

YouTube video by ESPN FC

youtube.com

A clear, succinct, datapoint-by-datapoint summary of recent work on design, synthesis, nonclinical testing, regulatory review, and patient dosing on the world's first "CRISPR on-demand" clinical trial for Baby KJ of Philadelphia. 🙏 @oligogirl.bsky.social !

Annemieke Aartsma-Rus@oligogirl.bsky.social · last yr.

#apaperaday is back from holiday. Yuzu is still with the birbsitter so a holiday picture it is. Today's pick is from @nejm.org by Musunuru et al on an N=1 case (patient with severe metabolic disease) treated by base editing (CRISPR therapy). DOI: 10.1056/NEJMoa2504747 Very good way to restart!

A clear-eyed report by @jasonmast.bsky.social on the path from N=1 (baby KJ) to N=many. www.statnews.com/2025/05/26/w...

What Baby KJ means for the CRISPR gene editing industry

The custom-built gene editing treatment for 6-month-old KJ Muldoon could not have come at a more welcome or jarring time for CRISPR-powered biomedicine.

statnews.com