Catch us at a conference: Ivan Liachko takes the stage at FutureinReview on 6/1 for a panel called “Gut Feeling: Hacking Your Microbiome”. Later that week, from 6/4 to 6/7, he’ll be on the ground at ASM Microbe 2026 in DC. Say “hey 👋” and connect for the latest in Hi-C!

Breeding is supposed to narrow diversity. A new hexaploid oat pangenome in @nature.com shows that's not the whole story. HiFi + Hi-C across 30+ lines revealed breeders have been adding structural diversity all along. Jeff Maughan, PhD, breaks it down in the clip below:

The biggest sustainability challenges are rooted in biology we’re still learning to understand. Hi-C helps build better genomes and unravel microbial communities that support healthier soils, stronger crops, and more resilient ecosystems. Happy 🌎 Day from Phase Genomics.

Long reads get you contigs. Proximo™ Hi-C Kits for Plants get you chromosomes you can put to work or meaningful trait / QTL mapping and functional analysis. Tell us about your research and take 20% off through May 1👇 info.phasegenomics.com/hi-c-plant-g...

One oat line has more structural variation than a panel of wheat lines. That finding, from the 1st chromosome-scale oat assembly, led to a 30-line hexaploid oat pangenome published in @nature.com using HiFi + Hi-C. Full breakdown from senior author Jeff Maughan, PhD, in the clip below:

Your research budget just got a little more room to grow. Take 20% off Proximo™ Hi-C Kits for plant genomics until May 1st. Hi-C unlocks chromosome-scale insights from your long reads. Get started here 👇 info.phasegenomics.com/hi-c-for-plants

New in the Journal of Water and Health: ProxiMeta™ Hi-C metagenomics improves antimicrobial resistance tracking in wastewater. Key findings: → 2,816 traits detected → 554 genes linked to hosts → 52.9% of genes were ARGs 🔗 iwaponline.com/jwh/article/...

32% off ProxiMeta™ Hi-C kits ends 3/15 (then save 16% through end of month). You’ll get: ✅ High-quality MAGs from complex samples ✅ More complete genomes than traditional binning ✅ Accurate host attribution for phages, plasmids, and AMR genes 👉 info.phasegenomics.com/march-magness

March MAGness is here! Score special pricing on ProxiMeta™ Hi-C kits for metagenomics & microbiome studies in everything from complex soil samples, to gut microbiomes, to bioreactors: 🔬 32% off | March 2–15 🔬 16% off | March 16–31 Get started here 👇 info.phasegenomics.com/march-magness

FISH finds what it's looking for, and only what it's looking for. In a new study in @AjHematologyshows, Hi-C confirmed FISH findings, plus chromothripsis, CN-LOH & complex rearrangements that FISH probes can’t pinpoint. 🔗https://onlinelibrary.wiley.com/doi/epdf/10.1002/ajh.70219

New Nature Plants study using Proximo™ Hi-C shows how a hybrid eelgrass species inherited low-light tolerance genes from its deep-water parent that could change how we approach coastal restoration. More from Todd Michael, PhD & team at @salkinstitute.bsky.social l 📄 www.nature.com/articles/s41...

New Publication in @plosbiology.org: Optimized Hi-C analysis (Z-score filtering) boosts specificity & reveals virus-host interactions using Phase Genomics’ ProxiMeta™ Hi-C: 79 genus-level matches + 293 new linkages in well-studied, climate-critical soils. journals.plos.org/plosbiology/...

Benchmarking with synthetic communities provides a baseline for virus-host inferences from Hi-C proximity linking

Virus discovery has accelerated but linking viruses to hosts remains challenging. This study uses synthetic microbiomes to optimize and benchmark Hi-C for virus-host linkage inference, and applies thi...

journals.plos.org

"A year and a half ago, we couldn't have resolved this hybrid genome." New tech (long reads + Hi-C) let researchers separate parental haplotypes in eelgrass revealing which genes drive low-light tolerance. Todd Michael, PhD breaks down how:

Phase Genomics IRL: a few days together in Portland for real-time collab & creativity. Aligning on new products, pressure-testing ideas, a little fun behind the wheel. It’s how we build even better Hi-C tools for the researchers who rely on them. A few of our favorite moments👇

Tissue prep drives variability early in Hi-C workflows. A new STAR Protocol adds cryogenic tissue grinding before crosslinking, with safe pause points for optimized lab workflows. See how it improves reproducibility & library quality → star-protocols.cell.com/protocols/4702

Cell Press: STAR Protocols

STAR Protocols is an open access, peer-reviewed journal from Cell Press. We offer structured, transparent, accessible, and repeatable step-by-step experimental and computational protocols from all are...

star-protocols.cell.com

Wheels up ✈️ Our CEO Ivan’s headed to Newport Beach for Microbes in Wastewater. He’ll show how ProxiMeta™ links microbes, phages & the mobilome to track #AMR in wastewater. No coding. Just discovery. If you’ll be in Newport for the conference, say hi to @ivanliachko.bsky.social

We heard you. Our 25 in ’25 promo is extended through Jan 16. Save 25% on Phase Genomics Hi-C kits via direct order, book a complimentary bioinformatics consult, and access discounted full-service ProxiMeta™ packages. Get started → info.phasegenomics.com/25-in-25

Bees carry more than nectar. Their gut microbiomes buzz with plasmids, sharing tetracycline resistance genes across hives. Chris Robinson, PhD from Irene Newton, PhD’s lab used Hi-C to track these mobile elements & explore colony-specific patterns traditional metagenomics misses.

Stuck on Hi-C data? First 25 researchers to email get a free consult with our computational scientists—whether you're using our kits or another provider's. Email info@phasegenomics.com with "25 in '25 Bioinformatics Promo" in the subject line to claim yours.

Save 25% on Hi-C kits through Dec 31. From complex plant genomes to metagenome binning, Phase Genomics brings clarity to your toughest research questions. Email info@phasegenomics.com with "25 in '25 Kit Promo" in the subject line to claim your discount.

🌿 Scientists produced a high-quality, chromosome-scale genome for American pickleweed, a salt-loving, tetraploid marsh plant. With ~80k genes and detailed methylation data, this resource paves the way for understanding salt-tolerance & supporting salt-marsh conservation. 🔗 bit.ly/3XAQ7vT

New at #AMPath2025: He Fang, PhD, will showcase Genomic Proximity Mapping® (GPM) and CytoTerra® in #sarcoma. Stop by Level 2, 258ABC on 11/13 from 2:30 – 3:30 pm ET to discover how GPM uncovers hidden structural variants and mosaicism in challenging archival samples.

🌿 New in @NaturePlants! Researchers used Phase Genomics’ Hi-C to build a haplotype-resolved chromosome-scale #genome of a hybrid eelgrass (Zostera marina × Z. pacifica), revealing genomic clues to low-light tolerance that could boost coastal restoration. www.nature.com/articles/s41...

Hybridization and low-light adaptability in California eelgrass (Zostera spp.) - Nature Plants

Seagrass genomes of the deep-water Zostera pacifica and shallow-water Z. marina from the Eastern Pacific Ocean provide evidence for low-light adaptation exemplified in the wild hybrid Z. marina × paci...

nature.com

Big spotlight on Genomic Proximity Mapping® (GPM®) from Elsevier's JMD: See how UW researchers use our GPM platform, CytoTerra®, to detect cryptic structural variants and mosaicism missed by standard tests. Full press release from @elsevierconnect.bsky.social: www.elsevier.com/about/press-...

Phase Genomics Hi-C helped untangle the pomegranate genome, ordering contigs into chromosome-scale scaffolds, clarifying chromosome counts & revealing domestication patterns. Full study from the Volcani Center: link.springer.com/article/10.1...

Phase Genomics’ Hi-C tech helped undergrads assemble the “best duckweed genome yet,” giving them hands-on research experience, boosting PhD prospects, and advancing plant biology. Full story from Alex Harkess at HudsonAlpha on YouTube: na2.hubs.ly/H01P7mG0

Hi-C at scale is reshaping plant biology. With Phase Genomics’ kits, Alex Harkess & HudsonAlpha have published dozens of genomes, uncovered how rising CO₂ alters chromatin structure, and explored how climate change ripples through living systems. 🔗 youtu.be/5-Ub7FnpHzs?...

Hi-C in Action: Faster Discoveries, More Publications, Bigger Impact | with Alex Harkess

YouTube video by Phase Genomics

youtu.be

Happy #WorldPhageDay. Tiny, abundant, and anything but boring, phages shape microbial communities, move genes around, and can tip the balance in all kinds of ecosystems. The catch: to know a #phage only you must know its host. ProxiMeta Hi-C technology gives us that link.

🌳 New chromosome-level Ulmus minor (field elm) genome unlocks clues to Dutch elm disease resistance. Using long reads and Hi-C, the team built this 2.1Gb genome and mapped clusters of resistance genes conserved across elm species to aid restoration. na2.hubs.ly/H01HQ2Q0

ProxiMeta™ Hi-C fills the missing link in shotgun metagenomics, connecting viruses to hosts & revealing hidden microbial relationships. Hear more from Phil Hugenholtz & Phase Genomics CEO Ivan Liachko on how Hi-C unlocks the microbiome → www.youtube.com/watch?v=DYMv...