Phil Carella

@philcarella.bsky.social

Exploring the evolutionary diversity of plant-pathogen interactions. Group Leader at the John Innes Centre. 🇨🇦 in 🇬🇧

How do transcription factors bind DNA strongly, and in a switch like manner, while remaining sequence specific? Our new paper on a canonical plant TF suggests the answer is a previously underappreciated assembly state: transcription factor nanoclusters. www.science.org/doi/10.1126/...

Nanoclustering of a plant transcription factor enables strong yet specific DNA binding

Transcription factor nanoclusters balance the DNA binding trade-off between weakly binding oligomers and nonspecific condensates.

science.org

Most TF families predictive for organismal complexity were gained during early plant evolution and act as homo- as well as heterodimers. Together, this suggests that gain of TF families as well as the rewiring of GRNs after gene duplication events are causative for plant morphological evolution.

Stefan A. Rensing @rensingstefan.bsky.social · 2w ago

Can the pretrained transformer-based architecture TabPFN predict plant organismal complexity based on their complement of transcription factors? Yes it can: www.biorxiv.org/content/10.6... Happy to hear your thoughts! @dvarshney.bsky.social @jandevries.bsky.social @watertoland.bsky.social

Engineering an Exo70 integrated domain of a barley NLR for improved blast resistance (Indira Saado, Helen J Brabham, Josh W Bennett, Anson Ho Ching Lam, Inmaculada Hernández-Pinzón , Matthew J Moscou, Juan Carlos De la Concepcion , Mark J Banfield) doi.org/10.1093/plce... #PlantScience @aspbofficial

Engineering an Exo70 integrated domain of a barley NLR for improved blast resistance

Engineering the barley NLR RGH2 enhances recognition of blast pathogen effectors from rice and wheat, leading to improved disease resistance.

doi.org

VACANCY - We’re looking for a Research Assistant to join the Penfield Group, working to understand the effects of temperature on plant reproductive development. https://okt.to/QvL4co Deadline - 18 August 2026 Contract - Until 7 August 2029, full-time

Research Assistant (Penfield Group) | John Innes Centre

An exciting opportunity has arisen for a Research Assistant to join the Penfield Group at the John Innes Centre, working on cutting-edge science in the field of Crop Genetics.

okt.to

Now published in JBac. Absolutely great publishing experience!!! Thank you to editors and reviewers.https://journals.asm.org/doi/10.1128/jb.00286-26 Another great one from @tommclean.bsky.social @johninnescentre.bsky.social @hbio-isp.bsky.social

TrbA binds and locks a sliding clamp KorB to repress transcription on multi-drug resistance plasmids | Journal of Bacteriology

Precise regulation of gene expression ensures gene products are produced at the right time and in the right amounts. Recent works uncovered a new mechanism of bacterial gene regulation based on a clamp sliding and locking in a multi-drug resistance plasmid, RK2. KorB functions as a CTP-dependent DNA-sliding clamp capable of traveling over a long genomic distance. Sliding KorB is captured and locked in place by a partner protein, KorA, forming a stable complex at target promoters to repress transcription. Here, we show that another RK2 regulator, TrbA, also uses this clamp sliding-locking mechanism, and identify an aromatic interface enabling TrbA-KorB-mediated transcriptional repression. Our findings show how a single sliding clamp integrates multiple partners to build a complex transcriptional regulatory network.

journals.asm.org

Tung Le@tunglejic.bsky.social · 3mo ago

Here, @tommclean.bsky.social shows that another RK2 regulator, TrbA, likely also use this “clamp sliding-locking” mechanism to regulate gene expression. Interesting how a single sliding clamp might integrate multiple partners to potentially build a complex regulatory network... shorturl.at/YQJOI

I’m thrilled to share that our search for a tenure-track colleague in my *truly wonderful and collegial* Genetics, Genomics, Evolution and Development Division in the MCB Department at Berkeley @berkeleymcb.bsky.social is live! Please share this broad search widely: aprecruit.berkeley.edu/JPF05481

Assistant Professor -Genetics, Genomics, Evolution, and Development - Molecular and Cell Biology

University of California, Berkeley is hiring. Apply now!

aprecruit.berkeley.edu