Philip Gunkel
@philipgunkel.bsky.social
Postdoc at the MPI for Multidisciplinary Sciences in Göttingen; Research focus: the nuclear pore complex (NPC) and in particular the nuclear basket - composition, function and beyond...
Fantastic paper from the Kutay Lab. A must-read...
Kutay lab@kutaylab.bsky.social · 6mo agoWe are delighted by the publication of our work identifying human LBR and LAP2 as key heterochromatin tethers at the nuclear envelope. Their loss massively changes 3D chromatin organization, and causes defects in epigenetic maintenance and cell fate determination. doi.org/10.1038/s415...
☕ @kutaylab.bsky.social & co identify #lamin B receptor (LBR) and lamina-associated polypeptide 2 (LAP2) as major factors that tether #heterochromatin to the envelope. Deletion of these proteins causes changes in 3D #genome organization, gene expression and cell fate determination. bit.ly/4aPkNBc
LBR and LAP2 mediate heterochromatin tethering to the nuclear periphery to preserve genome homeostasis - Nature Cell Biology
Lewis et al. identify lamin B receptor (LBR) and lamina-associated polypeptide 2 (LAP2) as major factors that tether heterochromatin to the envelope. Deletion of these proteins causes changes in 3D ge...
bit.ly
We are excited to share the revised version of our preprint elucidating the role of Annulate Lamellae in the assembly of Nuclear Pore Complexes #NPCs during early interphase. Big thanks to Junyan Lin and all collaborators for their fantastic work! 🙏🎉
RanBP2-dependent annulate lamellae drive nuclear pore assembly and nuclear expansion
Nuclear pore complexes (NPCs) enable nucleocytoplasmic transport. While NPCs primarily localize to the nuclear envelope (NE), they also appear in cytoplasmic endoplasmic reticulum (ER) membranes calle...
biorxiv.org
We are very excited that our work on Torsins, dystonia and NE membrane fusion is out on bioRxiv: doi.org/10.1101/2025... Fantastic collaboration with Madhav Jagannathan and the labs of Gautam Dey and Stefano Vanni!
Dystonia-associated Torsins sustain CLCC1 function to promote membrane fusion of the nuclear envelope for NPC biogenesis
DYT1 early-onset dystonia is a severe, incurable disorder of the central nervous system caused by mutations in the gene encoding Torsin1A (Tor1A, DYT1). Torsins are ER-resident AAA+-ATPases implicated...
doi.org
Congratulations to Dirk Görlich and Steven L. McKnight, 2025 #LaskerAward winners! - “for discoveries that exposed the structures and functions of low-complexity domains within protein sequences” 🧪 @mpi-nat.bsky.social #Lasker2025 #LaskerLaureate #structuralbiology #phaseseparation
Governed by surface amino acid composition: HIV capsid passage through the NPC barrier https://www.biorxiv.org/content/10.1101/2025.03.13.643050v1
Registration is open for a great meeting in Potsdam, Germany (July 23-27) ... for everyone interested in the biology of the nuclear envelope and related topics (events.gwdg.de/event/1012/)
📣 Join us for #EESNucleus 🧬 Explore the dynamic world of the nucleus at the new EMBO | EMBL Symposium. From nuclear mechanics to pathomechanisms, join the conversation shaping modern cell biology. 🗓️ 18 – 21 November 2025 📥 Submit your abstract by 26 August 👉 https://s.embl.org/ees25-07-bl
