OMG! A proteomic determinant of #neurodegenerative resiliency Michael R. Duggan, Hamilton Se-Hwee Oh, Philipp Frank...Keenan A. Walker #proteomics #AlzheimersDisease link.springer.com/article/10.1...

"Focusing on specific symptom patterns rather than treating depression as a single, unitary construct could improve early identification of individuals at increased risk of dementia and inform targeted prevention strategies." New free research article: www.thelancet.com/journals/lan...

Specific midlife depressive symptoms and long-term dementia risk: a 23-year UK prospective cohort study

A distinct set of midlife depressive symptoms was associated with an increased risk of dementia, suggesting that these symptoms might be early markers of underlying neurodegenerative processes. These ...

thelancet.com

Six particular depressive symptoms when experienced in midlife predict dementia risk more than two decades later, finds a new study led by Dr @philippfrank.bsky.social @uclpsychiatry.bsky.social @whitehall2study.bsky.social www.ucl.ac.uk/news/2025/de...

Clustering Patients with Pulmonary Hypertension Using the Plasma Proteome Plasma proteomics reveals four molecular clusters in pulmonary hypertension with distinct survival and therapeutic targets @atscommunity.bsky.social #medsky 🔓 Open Access 🔗 tinyurl.com/bpa36xt7

It was a pleasure to celebrate Whitehall II's 40th anniversary this month at UCL with Professor Sir Michael Marmot who set up the study in 1985. Watch the recording of the event here: www.youtube.com/watch?v=__gL...

2 new studies on weight loss 1. Sustained reduction during midlife improved survival and reduced chronic diseases jamanetwork.com/journals/jam... 2. A randomized trial found patient-to-patient care was more effective than professional for weight loss and less CV risk jamanetwork.com/journals/jam...

Long-term follow-up shows that losing weight in midlife—without surgery or medication—can lower the risk of chronic diseases later in life jamanetwork.com/journals/jam...

Weight Loss in Midlife, Chronic Disease Incidence, and All-Cause Mortality

This cohort study investigates the association of sustained weight loss in midlife with long-term health benefits.

jamanetwork.com

People with social disadvantage, during both early and later life, have an increased risk of 66 age-related diseases mediated by 14 age-related proteins, according to a paper in Nature Medicine. https://go.nature.com/4ifgD6T #Medsky 🧪

People with favourable socioeconomic conditions, e.g. high incomes or education levels, face a reduced risk of age-related diseases and show fewer signs of biological ageing than same-aged peers, finds a study led by Prof Mika Kivimaki @uclbrainscience.bsky.social with @ucllifesciences.bsky.social

Social disadvantage can accelerate ageing and increase disease risk

People with favourable socioeconomic conditions, such as high incomes or education levels, face a reduced risk of age-related diseases and show fewer signs of biological ageing than peers of the same ...

ucl.ac.uk

This multicohort study links social disadvantage to accelerated ageing, highlighting NF-κB activation as a key underlying mechanism. #Aging #SocialDeterminants #NFkB rdcu.be/edyqo

Social disadvantage accelerates aging

Nature Medicine - Individuals with social disadvantage, during both early and later life, have an increased risk of 66 age-related diseases mediated by 14 age-related proteins.

rdcu.be

#Ageing is not just about time - it is also shaped by social conditions. In our latest study published in @naturemedicine.bsky.social , we show that social disadvantage is linked to biological ageing @mikakivimaki.bsky.social @uclbrainscience.bsky.social @whitehall2study.bsky.social

Our latest publication in the Lancet Digital Health shows that organs age at different rates. Proteomic data from 6235 Whitehall II Study participants revealed that accelerated ageing of specific organs are predictive for over 30 age-related diseases. Link to paper: www.thelancet.com/journals/lan...

Proteomic organ-specific ageing signatures and 20-year risk of age-related diseases: the Whitehall II observational cohort study

Advanced proteomic organ ageing is associated with the long-term risk of age-related diseases. In most cases, faster ageing of a specific organ increases susceptibility to morbidity affecting multiple...

thelancet.com

Our organs age at different rates, and a blood test determining how much they’ve aged could predict the risk of conditions like lung cancer and heart disease decades later, finds a new study led by Prof Mika Kivimaki @uclbrainscience.bsky.social @whitehall2study.bsky.social

Biological organ ages predict disease risk decades in advance

Our organs age at different rates, and a blood test determining how much they’ve each aged could predict the risk of conditions like lung cancer and heart disease decades later, finds a new study led ...

ucl.ac.uk

Protein organ clocks, as assessed in over 6,000 people (~4,000 plasma proteins, 8 organs) with 20-year follow-up are predictive for over 30 age-related diseases www.thelancet.com/journals/lan...

🔬Our latest research published in the Lancet Digital Health shows that different organs age at different rates, and that accelerated biological ageing is linked to a higher risk of age-related diseases—including multimorbidity across multiple organs. www.thelancet.com/journals/lan...

Proteomic organ-specific ageing signatures and 20-year risk of age-related diseases: the Whitehall II observational cohort study

Advanced proteomic organ ageing is associated with the long-term risk of age-related diseases. In most cases, faster ageing of a specific organ increases susceptibility to morbidity affecting multiple...

thelancet.com