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Andoniadou Lab

@pituitarylab.bsky.social

Pituitary stem cell research, but we also love an adrenal. KCL, London

8 Posts163 Follower192 Folgt
Bence Kövér@bencekover.bsky.social · 2mo ago

Happy to see our new review paper led by @jameskcl.bsky.social . We discuss evidence on the role of stem cells in pituitary tumours. Furthermore, we discuss practical criteria for identifying stem cells, and develop a framework for their possible contributions to tumours. @pituitarylab.bsky.social

Endocrine-Related Cancer@endocancer.bsky.social · 2mo ago

🧠 What role do stem cells play in pituitary tumour formation and progression? A new review examines the current evidence implicating pituitary stem cells and tumour stem-like populations in pituitary tumour biology. 🔗 Read the review: doi.org/10.1530/ERC-26-0171

Endocrine-Related Cancer logo. Open Access logo. The role of stem cells in pituitary tumour formation. By James Kaufman-Cook, Bence Kövér, and Cynthia L Andoniadou. Figure 3. Stem cell models of pituitary tumourigenesis. Schematic illustrating the potential roles of PSCs and TSC-like cells in tumour formation. Under oncogenic stimuli, stem cells can drive tumourigenesis through cell-autonomous mechanisms by proliferating rapidly, differentiating and directly giving rise to tumours, in a classic cancer stem cell (CSC) paradigm (purple box). Thus far, this has been demonstrated in SOX2+ cells harbouring mutations in BRAFV600E in human PCP. Tumourigenesis can also occur via non-cell-autonomous mechanisms (yellow box), where paracrine signals or a senescence-associated secretory phenotype from a transformed tumour-initiating cell (TIC) promotes proliferation and/or transformation of other cells into TSCs or TSC-like cells. Thus far, this has been demonstrated only in ACP. Whether TSC-like cells contribute to tumourigenesis through either cell-autonomous or non-cell-autonomous mechanisms in pituitary neuroendocrine tumours (PitNETs) remains to be determined. PSCs exposed to oncogenic stimuli that become lineage-committed may retain stem-like characteristics, marker expression or proliferative potential, contributing to tumour formation as TSCs. Conversely, and still unconfirmed, committed endocrine cells may undergo de-differentiation in response to oncogenic signals, acquiring stem-like properties and promoting tumourigenesis through either cell-autonomous or non-cell-autonomous pathways, as TSCs. These populations may also influence tumour progression by modulating the tumour microenvironment. Finally, healthy PSCs may become trapped within the expanding tumour mass and contribute to tumour maintenance or progression through... Endocrine-Related Cancer 33, 6; 10.1530/ERC-26-0171. Published by Bioscientifica logo. 80 Years 1946-2026 Society for Endocrinology logo.
Jérôme Bertherat@jeromebertherat.bsky.social · last yr.

The first-ever joint ESPE-ESE congress will begin this Saturday. I look forward to meeting our warm and vibrant community in Copenhagen. 👇👇👇 PS: For those unable to attend, there is still time to register online to participate in this great event !

European Society of Endocrinology@esendocrinology.bsky.social · last yr.

Registration for the Joint Congress of ESPE and ESE 2025 is still possible! If you cannot travel to Copenhagen join us remotely via @ HOME. Register now at ow.ly/gTL150VM6mW