Bence Kövér
@bencekover.bsky.social
PhD student at King’s College London @pituitarylab.bsky.social Previously at UCL (2019-23) working on multicellularity in fission yeast, and exchange student at Caltech (2021-22)
Wow, such a cool paper. I guess there might come a time when we can reconstruct the entirety of embryonic development.
Jay Shendure@jshendure.bsky.social · 5d agoThrilled to post thread re: new single-cell lineage of mouse embryo reconstructed w/ DNA Typewriter. One animal, zygote to late organogenesis (E13.5). Tree has 1,340,794 transcriptionally profiled, annotated tips (cells), 1,142,588 dated internal nodes, rooted at zygote 1/n
Really cool to have our lab featured by @plasmidsaurus.bsky.social . It’s been a massive boost in productivity to use their rapid bulk RNA-seq and whole plasmid sequencing services.
plasmidsaurus@plasmidsaurus.bsky.social · 3w agoThe @pituitarylab.bsky.social is uncovering the transcription factors that define pituitary cell types, shedding light on hormone deficiencies and hormone-secreting tumors. With Plasmidsaurus RNA-Seq, they've scaled to transcriptome-wide analysis across many engineered cell lines. Learn more →
Very cool! So much left to discover in pre-eukaryotic life
Chung Hyun Cho@chc-evobio.bsky.social · last mo.Excited to share our new preprint led by Fred and me in collaboration with the archaeal community! We found that the molecular foundation of histone-based chromatin has pre-eukaryotic roots in Asgard archaea. (1/4) #ArchaeaSky www.biorxiv.org/content/10.6...
Happy to see our new review paper led by @jameskcl.bsky.social . We discuss evidence on the role of stem cells in pituitary tumours. Furthermore, we discuss practical criteria for identifying stem cells, and develop a framework for their possible contributions to tumours. @pituitarylab.bsky.social
Endocrine-Related Cancer@endocancer.bsky.social · last mo.🧠 What role do stem cells play in pituitary tumour formation and progression? A new review examines the current evidence implicating pituitary stem cells and tumour stem-like populations in pituitary tumour biology. 🔗 Read the review: doi.org/10.1530/ERC-26-0171
Consensus Pituitary Atlas, a scalable resource for annotation, novel marker discovery, and analyses in mouse pituitary gland research
Consensus Pituitary Atlas, a scalable resource for annotation, novel marker discovery, and analyses in mouse pituitary gland research
Single-cell studies of the pituitary gland have been limited by small datasets and inconsistent analyses. Kövér and colleagues integrate 283 datasets (∼1.3 million cells) to build the Consensus Pituitary Atlas, which enables robust marker discovery, automated cell annotation with machine learning, and accessible analysis through the epitome platform.
dlvr.it
TL;DR: We've identified more than 100 cases of apparent manipulation in Thermo Fisher Scientific's antibody verification data. @sholtodavid.bsky.social @johanduchene.bsky.social reeserichardson.blog/2026/05/28/h...
How much of Thermo Fisher’s antibody data has been manipulated?
We’ve documented more than 100 instances of apparent data manipulation in Thermo’s catalog
reeserichardson.blog
Really excited to share that the first part of my PhD is now published in Cell Reports @cp-cellreports.bsky.social @cellpress.bsky.social. We generated the Consensus Pituitary Atlas, a resource of 283 pituitary single-cell samples, totalling ~1.3 million cells. Thread below. 1/19
The pituitary gland may be small, but its impact is huge - regulating growth, stress, reproduction and more. Now, a new study has created a detailed map of how this essential gland works. www.kcl.ac.uk/news/new-atl...
New Atlas reveals more about how the body's “master gland” really works | King's College London
A new study has created a detailed map of the pituitary gland, often called the body’s “master gland” as it controls important functions like growth, stress, and reproduction.
kcl.ac.uk
Arc Institute’s “MULTI-evolve” learns a classical additive model, not epistasis. Preprint (w/ Gian Marco Visani and Aayush Verma): www.biorxiv.org/content/10.6... Blog: dewitt-lab.github.io/posts/2026-0...
Additivity is all you need?
Arc Institute’s “MULTI-evolve” learns a classical additive model, not epistasis.
dewitt-lab.github.io
In my book Twilight of Democracy, I wrote about how authoritarian populism had divided friends, including in Hungary. After Prime Minister Magyar was sworn in today, he said he hoped "Family, friends and communities will be able to speak to each other again." www.theguardian.com/world/2026/m...
Péter Magyar sworn in as Hungary’s prime minister to end 16-year Orbán era
Jubilation in Budapest as Péter Magyar becomes leader and invites people to ‘step through gate of regime change’
theguardian.com
I’m really glad to have been a part of this exciting project studying rare neuroendocrine tumours called phaeochromocytomas and paragangliomas. We performed 10x Genomics single-cell/nucleus RNA-seq on 7 PPGL patients, and integrated published data from another 12 patients. doi.org/10.1530/ERC-...
doi.org
We’ll be sharing a detailed blog post in the coming days with everything that was built, discussed, and what comes next. Stay tuned 🚀
A really great and in-depth summary by @heineikeb.bsky.social on our new paper where we dissect the genetics of multicellular-like phenotypes in fission yeast. It was truly a great project the work on, and strongly shaped me as a scientist. I never thought sticky yeast could be so cool! Thanks Ben!
Ben Heineike@heineikeb.bsky.social · 5mo agoProud of our new paper just out in the @genetics-gsa.bsky.social's #GENETICS journal academic.oup.com/genetics/adv...!
Happy to share scHiCAR, an ultra-high throughout (millions of cells), low cost (5 cents/cell including NGS), and trimodal platform for integrated single-cell level analysis of mRNA, open chromatin, and 5-kb resolution looping with ground-truth data the same individual cell.
Nature Biotechnology@natbiotech.nature.com · 6mo agoTrimodal single-cell profiling of transcriptome, epigenome and 3D genome in complex tissues with scHiCAR - @yaruidiao.bsky.social @dukehealth.bsky.social go.nature.com/4rZqimf
And unfortunately Wilcoxon remains what most people do in their standard scRNA-seq differential expression analysis between thousands of pseudoreplicates…
Wolfgang Huber@wkhuber.bsky.social · 8mo agoWhy does anyone use the Wilcoxon test for anything? It's not even transitive. It's sensitive to things one most likely is not looking for (changes in distribution shape) and relatively insensitive to what one usually is looking for (change in location). www.sciencedirect.com/science/arti...
Not sure why @lpachter.bsky.social did not post this here. But it is brilliant. Single cell genomics finally makes it to the clinic.
The protein concentration in the cytoplasm is so high that the average protein has a water hydration shell with a thickness of only ≈ 10 water molecules separating it from the adjacent protein hydration shell. 1/2
Excited to release the Consensus Pituitary Atlas, which brings a shared framework to process, annotate, and analyze single-cell datasets in the mouse pituitary. www.biorxiv.org/content/10.1...
Happy to share the Biodiversity Cell Atlas white paper, out today in @nature.com. We look at the possibilities, challenges, and potential impacts of molecularly mapping cells across the tree of life. www.nature.com/articles/s41...
This Tuesday I attended the annual @londonomics.bsky.social symposium at the @crick.ac.uk , and presented a methods-focused version of some of the research I’ve done this past year.
We're still not finding any good evidence for a microbiome in any cancer type: see our new paper in @ScienceTM led by PhD student Yuchen (Peter) Ge www.science.org/doi/10.1126/... and the accompanying news piece, www.science.org/content/arti...
Comprehensive analysis of microbial content in whole-genome sequencing samples from The Cancer Genome Atlas project
An analysis of TCGA whole-genome sequencing samples yields a comprehensive resource for investigating the role of microbes in cancer.
science.org
1/27 We have a new paper out! Turns out that snowflake yeast have been hiding a secret from us - they've evolved a (very!) crude circulatory system. Not with blood vessels or a heart, but through spontaneous fluid flows powered by their metabolism. 🧪🔬 www.science.org/doi/full/10....
I had a great time presenting a poster of my research project at the Joint Congress of @esendocrinology.bsky.social and ESPE in Copenhagen.
Between serious research, our lab took some time out today for a fun hormone-themed activity. Endocrinology escape room- all about hormones! #BecauseHormonesMatter #WorldHormoneDay #pituitary #adrenal #endocrineresearch @esendocrinology.bsky.social @ese-eyes.bsky.social @pituitaryorg.bsky.social
Striking new study from @archaeon-alex.bsky.social's lab just out in @science.org on multicellular development induced by compression in Archaea: www.science.org/doi/10.1126/...
Tissue-like multicellular development triggered by mechanical compression in archaea
The advent of clonal multicellularity is a critical evolutionary milestone, seen often in eukaryotes, rarely in bacteria, and only once in archaea. We show that uniaxial compression induces clonal mul...
science.org
The more jargon you have in your paper the less citations you'll get. royalsocietypublishing.org/doi/10.1098/...
David Baker talks about how the current uncertainty and instability hinder creativity because of the difficulty in thinking long-term. From this week’s Night Science Podcast nightscience.buzzsprout.com/1744020/epis... @nightsciencepod.bsky.social
I miss when the biggest controversy about mRNA was whether it correlated with protein or not.
