Martin Plöderl
@ploederl.bsky.social
Clinical psychologist and psychotherapist, part-time researcher with a focus on suicide prevention and psychopharmacology. https://ploederlm.github.io/publications/ https://scholar.google.at/citations?user=76cO6AEAAAAJ&hl=de Nature, espresso, cycling.
A Harvard psychiatrist explains how SSRIs work with the chemical imbalance theory. Which is said that it was never taken seriously in psychiatry 🙄
Thorsten Padberg@padbergthorsten.bsky.social · 11h agoNiemand hat je behauptet, Depressive hätten zuwenig Serotonin. Psychiaterin: www.youtube.com/watch?v=z_yG...
41 degree Celsius in Austria. All time high! wien.orf.at/stories/3365...
41 Grad: Allzeithöchstwert gemessen
Am Dienstagnachmittag wurde ein neuer österreichweiter Allzeit-Temperaturhöchstwert aufgestellt. In Wien-Stammersdorf wurden am Dienstagnachmittag 41 Grad gemessen, wie aus Daten der GeoSphere Austri...
wien.orf.at
Likely the best observational study on lithium and suicide. Sometimes being a peer reviewer is a privilege, not a burden mentalhealth.bmj.com/content/29/1...
Lithium for the prevention of suicide in US veterans: a target trial emulation
Background Lithium has long been considered to reduce suicidal behaviour in patients with affective disorders, but evidence from large real-world populations remains limited.Objective To estimate the ...
mentalhealth.bmj.com
I love the mood in this song so much www.youtube.com/watch?v=hTj0... A good sound system is necessary to unfold it. @davidef.bsky.social
Hundreds - Ten Headed Beast (official music video)
YouTube video by Sinnbus
youtube.com
Three reasons to be happy today. 1/ I'm on holiday (long overdue)... 🏝️
🙈🙈🙈
allen institute@alleninstitute.org · 5d agoKetamine increases neuroplasticity in female mice but not males. With @istaresearch.bsky.social, we found the key gene behind the difference. If it holds in humans, it could reshape how we approach assessing treatments. 🔗 Story: https://bit.ly/4yM4hvL 🔬 Journal article: https://bit.ly/4pYisK8
This paper cites our meta-analysis of RCTs (!) on antidepressant and suicidal behavior where we found a signal for harm. "Counterintuitively, and without evidence of causality, some even infer that the treatments themselves cause suicide" So they have no clue about RCTs. Peinlich.
Suicide prediction, prevention, and the blame culture: A narrative review based on trends in mortality rates | European Psychiatry | Cambridge Core
Suicide prediction, prevention, and the blame culture: A narrative review based on trends in mortality rates - Volume 68 Issue 1
cambridge.org
1. New paper on biases associated with response rate odds-ratio as outcome in antidepressant trials. There's the convention of using a 50% reduction from baseline to define "response". Totally arbitrary. Or not? It maximizes the odds-ratio, giving a biased impression of efficacy.
Highlighting a Systemic Bias in the Responder Odds Ratio
Click on the article title to read more.
onlinelibrary.wiley.com
Canadian politician Bill Oliver has gone viral after he appeared to accidentally read AI-generated editing instructions aloud, not once, but twice, during a speech to lawmakers in early June.
The top 10% in America consume 50% of resources, products, and services. How much does a human need to consume to live a good life? www.morningbrew.com/stories/weal...
The top 10% of Americans account for nearly half of consumer spending
Commerce data released yesterday showed that spending at US retailers jumped 0.6% last month, more than double economists’ expectations of 0.2%.
morningbrew.com
Albert Pinto@70sbachchan.bsky.social · 9mo agoTop 10% by income now getting half of all consumption
Post a perfect album from the 90's that isn't nirvana, soundgarden, pearl jam, or Alice In Chains
New preprint led by Tala Jajieh from the ResToRes project. By analysing RCTs with confirmed data fabrication, our new preprint reveals that most zombie trials arise from monocentric, recurrent patterns of misconduct and often remain undetected for many years. www.medrxiv.org/content/10.6...
It is incredibly difficult to show that national suicide prevention programs can reduce suicide rates, as discussed in this review of related studies. What I miss: most programs include awareness programs, and there is recent evidence for iatrogenic effects of such programs.
Evaluating the outcomes of national suicide prevention strategies: evidence and challenges
The public health approach to suicide prevention recognises the importance of maintaining a whole-of-government policy focus. In many countries, this focus is achieved through the planning and impleme...
thelancet.com
I'm reposting this after discovering more problems (thanks @ploederl.bsky.social). BOTTOM LINE: No trials have tested antidepressants in preschool children. This one has major flaws, including some that erode trust in the whole paper. See why psych-partners.com/fluoxetine-f... #psychiatry #pmhnp
Fluoxetine: A Problematic Trial in Ages 4-6 - PsychPartners
The first trial to test fluoxetine (Prozac) in children as young as four with major depression. See the results, the safety signal that didn't match the data, and what to do next.
psych-partners.com
Chris Aiken, MD@chrisaikenmd.bsky.social · 3w agoHere's the first trial to test fluoxetine for #depression in children under 6: psych-partners.com/fluoxetine-f... Positive signal, but agitation is a risk, and a single study doesn't change the fact that Parent-Child Interaction #Therapy has the best evidence in this age group. #psychiatry #pmhnp
From Alessandra Olanow, Brooklyn-based artist and poet, the author of 'I Used To Have A Plan'.
'If transporting an 80-kg person requires a vehicle weighing 1,500 kgs that consumes a 100 times as much energy, then from an energy perspective, that is absurd. However, the brain calculates this quite differently; all that matters there is saving one's own bodily energy—walking' #hermannknoflacher
8/ @JonasRueppel gives an insight how psychiatry keeps on promising a future of personalized treatment, despite the past/ongoing failures. He points out strategies/arguments to keep this promise alive. He used papers and interviews with psychiatrists working in biomarker research
1. It is concerning that, in an editorial of a leading psychiatric journal, there is a discussion of treatment effect heterogeneity, w/o distinguishing appropriate studies from those which simply looked at associations of variables with reponse/nonresponse without a placebo control group.
Editorial: Toward More Individualized Treatment of Pediatric Depression
For decades, antidepressant trials in children and adolescents have been designed to answer the question: does the medication work better than placebo? As clinicians, however, we confront a different ...
jaacap.org
Does the (live) shingles vaccine protect against dementia? Fergus Hamilton and colleagues provide important evidence in a new preprint using hospital data from the whole of England in a regression discontinuity design from which we *don't* show evidence of a meaningful protective effect /cont
Another depression study from Iran with implausible findings: - standard deviations too small - effect sizes too large (not impossible, but suspicious) - miscalculated effect size (at least for 6 weeks). They also referenced a retracted paper (even flagged as such on the journal homepage).
Rosiglitazone Adjunct to Sertraline for Major Depressive Disorder: A Randomized, Double‐Blind, Placebo‐Controlled Trial
Insufficient responses to available treatments for major depressive disorder (MDD) underscores the necessity for innovative therapeutic strategies. This study investigated the efficacy of adjunctive ....
onlinelibrary.wiley.com
Nach Spahn-Rücktritt: Postillon entlässt 700 Mitarbeiter www.der-postillon.com/2026/07/spah...
Nach Spahn-Rücktritt: Postillon entlässt 700 Mitarbeiter
Fürth (dpo) - Mitteilung in eigener Sache: Nach dem Rücktritt von Jens Spahn als Unions-Fraktionschef sind heute 700 Mitarbeiter des Postillon fristlo
der-postillon.com
Alternatives to the prescribing automatism ("unmedicated deemed as untreated") are much needed and first evidence is promising.
Prof. James Davies@drjamesdaviesbskys.bsky.social · 3w agoMedication-free mental health units are defying all expectations - the outcomes are good.... the larger dataset indicated superiority for 'med free treatment' in the full sample and noninferiority in sensitivity analyses". t.co/uG2ZYJx1is
The controversy around the boxed warning, as summarized by Bob Whitaker from @mad-in-america.bsky.social
Yet Another Claim About the Benefits of Antidepressants Bites The Dust
Former FDA officials write that claims that the black warning led to an increase in youth are "factually inaccurate in ways that are directly verifiable," echoing arguments published on Mad in America
madinamerica.substack.com
Martin Plöderl@ploederl.bsky.social · 4w agoThe boxed warning regarding treatment emerging suicide with antidepressants keeps on causing controversies. Here is a very recent exchange bw leading psychiatrists and (former) FDA officials. IMO, the latter have more convincing arguments.
For adults, DSM-IV deleted the time requirement for Social Anxiety Disorder. The checklist expanded. More people fit it. Wonder why the diagnosis feels so common now? This is a key reason. Pro-history, not anti-therapy. Talk to professionals. Read the sources. DSM-III, 1980, DSM-IV, 1994
Before 1980: 3 doors locked. No billing code. No pharma market. No diagnosis calling shyness an illness. 1980: ∼15 psychs voted yes on DSM-III 300.23. One vote unlocked insurance, pharma, identity. Behavior existed. Billion-dollar industries didn’t. Pro-history, not anti-therapy.
1. We wrote a letter to the editor about this fluoxetine trial for children aged 4-6. Given the urgency and the expected delay in response, we also published it as a preprint, available here: doi.org/10.31234/osf... Which problems did we detect with this study ? 🧵
Chris Aiken, MD@chrisaikenmd.bsky.social · 3w agoHere's the first trial to test fluoxetine for #depression in children under 6: psych-partners.com/fluoxetine-f... Positive signal, but agitation is a risk, and a single study doesn't change the fact that Parent-Child Interaction #Therapy has the best evidence in this age group. #psychiatry #pmhnp
