What an incredible few days at #ICBEM2026 in Barcelona! 🇪🇸 I had amazing fun co-chairing the session on #microglia and #metabolism, as well as sharing our work on how to stop chronic #brain inflammation 🚫🔥🧠 So inspired by this community! ✨🚀

I am proud to showcase emerging scientific topics and developments during a Science Spotlight session at the @ISSCR.org 2026 Annual Meeting, taking place in Montréal, Canada, on 8-11 July 2026. Register to hear my presentation! #ISSCR2026 invt.io/1bxblp1gmox

I'm speaking at ISSCR 2026 Annual Meeting, join me

Register now

invt.io

We are incredibly proud to have joined forces with @gregory-ms.com to launch brain-regeneration.com 🙌 This open observatory harnesses the power of GregoryAI to accelerate breakthroughs for everyone living with chronic neurological disorders 🧠 Please help us spread the word and share this big news! 🗣️

Honoured to be shortlisted for the Neurology INNLIFES award! As the winner is decided by public vote, I would truly appreciate yours. Please vote for Peruzzotti-Jametti under "Protagonisti dell’innovazione Neurologia". Shares are also a huge help! Thanks! www.indicon-innovation.tech/premio-i-pro...

Premio I Protagonisti dell’innovazione 2026

Come funziona il Premio Il Premio “I Protagonisti dell’Innovazione 2026” nasce con l’obiettivo di valorizzare professionisti, organizzazioni e startup che, nel corso del 2025, si sono distinti per la ...

indicon-innovation.tech

Epstein–Barr Virus, Lower Vitamin D, Low Sun Exposure, and HLA-DRB1*1501 Risk Variant Share Common Epigenetic Pathways Leading to Multiple Sclerosis Onset onlinelibrary.wiley.com/doi/full/10....

Epstein–Barr Virus, Lower Vitamin D, Low Sun Exposure, and HLA‐DRB1*1501 Risk Variant Share Common Epigenetic Pathways Leading to Multiple Sclerosis Onset

[Color figure can be viewed at www.annalsofneurology.org]

onlinelibrary.wiley.com

I am delighted to share that I have been appointed as Early Career Editor for @stemcellreports.bsky.social, the official journal of the International Society for Stem Cell Research @isscr.org! 🔬🌍 I look forward to seeing your research in the field of stem cells! Submit here: invt.io/1bxb9kpdtfj 👍

Check out ISSCR's society journal, Stem Cell Reports!

invt.io

⚠️ We are hiring a Postdoctoral Research Associate ⚠️ 🚨 Deadline 9th February 2026 🚨 👍 Please like and share with your network! 👍 #CambridgeUniversity #PostdoctoralResearch #JobOpportunity For enquiries please contact me at LP429@CAM.AC.UK or use this 🔗 to apply: www.cam.ac.uk/jobs/postdoc...

🚨ALERT: If you live in the USA, please contact Congress to prioritize Pharmacy Benefit Manager (PBM) reform, so that people with multiple sclerosis receive the medications meant for them!🚨 #MS #Healthcare Please click and act here before the ⚠️Jan 30 deadline⚠️: nmss.quorum.us/campaign/152...

Act Now: Tell Congress to Act on PBM Reform Before January 30

Contact Congress today!

nmss.quorum.us

A new CRISPR-based approach has identified key immune signals that regulate macrophage behavior in multiple sclerosis, offering deeper insight into the mechanisms driving neuroinflammation. doi.org/hbjfrf

New insight into the immune signals driving inflammation in multiple sclerosis

Multiple sclerosis (MS) is a chronic neurological disease characterized by nerve damage and consequent impairments in vision, movement, balance and mental function.

medicalxpress.com

3 papers on EBV and MS Anoctamin-2-specific T cells link Epstein-Barr virus to multiple sclerosis Anoctamin-2 (ANO2) is targeted by T cells in approximately 57% of persons with MS www.cell.com/cell/fu... 1/6

REVIEW | E Asimakidou, @lpjlab.org et al. (U Cambridge) How metabolic interactions between microglia and neurons shape brain health 🧪

The metabolic engine of cognition: microglia–neuron interactions in health, ageing and disease - Nature Metabolism

This Review highlights how metabolic interactions between microglia and neurons shape brain health, and how their disruption in ageing and disease contributes to cognitive decline.

dlvr.it

Merry Christmas from the LPJ Lab! 🎄 It’s been a joy to see the lab grow in 2025. I’m incredibly proud of this brilliant team and our shared mission to improve the lives of those with incurable diseases. Here’s to the challenges ahead! 💪 @camneuro.bsky.social @camneurodept.bsky.social @cam.ac.uk

New research in Nature Metabolism reveals that neuronal fatty acid oxidation is crucial for fueling memory formation after intensive learning. This metabolic shift supports the high energy demands in fruit flies. 🧠🪰 #Neuroscience #Metabolism #Memory www.nature.com/articles/s42...

Neuronal fatty acid oxidation fuels memory after intensive learning in Drosophila - Nature Metabolism

Neurons are shown to use fatty acid β-oxidation as a fuel source for memory formation upon intensive learning in Drosophila, challenging the view that neurons are unable to use fatty acids for energy…

nature.com

Please share the next "Neural Circuits of behavior" school in #Pisa, organised by @biancasilvalab.bsky.social We will be exploring how #neuroplasticity shapes the #brain and #cognition 🧠 #NeuroSky #Neuroscience ⚠️ Applications and #scholarships are open until 15/01/26 ⚠️ www.sns.it/it/evento/ne...

Neural Circuits of behavior: from synapses to action | ScuolaNormaleSuperiore

sns.it

Just wrapped up the CAJAL Advanced Neuroscience Training Programme in Bordeaux! 🍷🧠 It was a privilege to introduce such a brilliant group of students to the world of #Neuroimmunometabolism. The future of our field looks very bright! #Neuroscience #Immunology #Cajal #Bordeaux tinyurl.com/276b6upe

⚠️ Just out in @natmetabolism.nature.com ⚠️ Our latest review with @pluchinolab.bsky.social & @biancasilvalab.bsky.social explores how #microglia and #neuron #metabolism shapes #brain health and cognition! 🧠 Our Evridiki Asimakidou did a wonderful job leading this! 👏 www.nature.com/articles/s42...

The metabolic engine of cognition: microglia–neuron interactions in health, ageing and disease - Nature Metabolism

This Review highlights how metabolic interactions between microglia and neurons shape brain health, and how their disruption in ageing and disease contributes to cognitive decline.

nature.com

New Nature Metabolism review breaks down the history, role, and therapeutic promise of itaconate. Learn how this metabolite exerts potent anti-inflammatory effects—a crucial mechanism for future drug development! #Immunometabolism #Inflammation www.nature.com/articles/s42...

Metabolic Messengers: itaconate

McGettrick et al. provide a succinct yet broad overview of the immunometabolite itaconate as an immunomodulatory molecule.

nature.com

Fascinating read on #brain 🧠 tumor #immunology! Primary brain tumors vs metastases have fundamentally different immune microenvironments. This is why secondaries often show a better response to #immunotherapy. share.google/RJdXIc02PCyH...

The immunology of brain tumors | Science Immunology www.science.org/doi/10.1126/... Happy to share this review article by @lukasbunse.bsky.social, Theresa Bunse and I @platten-lab.bsky.social, Michael Kilian, Fran Quintana @quintanalabhms.bsky.social.

The immunology of brain tumors

The cellular and molecular determinants of the antigenicity of brain tumors and the immunosuppressive brain tumor microenvironment are reviewed.

science.org

New preprint: #Microglia don't just clear debris - they undergo a massive metabolic overhaul after phagocytosis, including adaptive mitochondrial changes, which may make them pro-regenerative! 🥳🧠💪 #Neuroscience #Mitochondria #Metabolism #BioRxiv www.biorxiv.org/content/10.1...

Metabolic and transcriptional adaptations to phagocytosis sustain microglia functionality and regenerative properties

Phagocytosis of apoptotic cells, or efferocytosis, is a tightly regulated process that ensures tissue homeostasis and prevents mounting inflammatory responses. In the brain parenchyma, it is executed ...

biorxiv.org

#PhD position available! Our collaborator Roberta Magliozzi is looking for a motivated student to map the meningeal immune landscape in #MultipleSclerosis. This is a great opportunity for anyone interested in neuroimmunology! 🧠 Please SHARE and APPLY here: www.imperial.ac.uk/brain-scienc...

Funding

Funding is often secured through Wellcome Trust or MRC DTP Fellowships. Further information about this and specific projects studying under the supervision of Departmental supervisors who have obtaine...

imperial.ac.uk

Session Six featured fantastic talks by Prof. Vendeuscolo from the Dept. of Chemistry @cam.ac.uk, Prof. Peruzzotti-Jametti from the Dept. of Clinical Neurosciences @cam.ac.uk, and the Andrew Huxley Plenary Lecture by our special guest Prof. Studer from the Sloan Kettering Cancer Center, NY #CNS2025

Human myelinated brain organoids with integrated #microglia as a model for #myelin repair and remyelinating therapies | Science Translational Medicine www.science.org/doi/10.1126/...

Human myelinated brain organoids with integrated microglia as a model for myelin repair and remyelinating therapies

Human myelinated brain organoids with integrated microglia can be used to investigate demyelination, remyelination, and remyelinating therapies.

science.org

An interview with Dr. Luca Peruzzotti Jametti on the topic of #Myelin repair. ms-perspektive.de/en/129-luca-... #MSchat #MultipleSclerosis #Neurology #StemCells @pluchinolab.bsky.social @restorems.bsky.social @lpjlab.org

Hope for Myelin Repair: Stem Cells & Progressive MS

Can neural stem cells support myelin repair and slow progression in MS? Dr. Luca Peruzzotti Jametti shares research, safety, and timelines.

ms-perspektive.de

Groundbreaking new paper on #Alzheimers disease: researchers found widespread "epigenome erosion" that is linked to cell-type-specific and region-specific changes that correspond with #microglial cell shifts, cognitive decline, and even cognitive resilience! www.cell.com/cell/fulltex...

Single-cell multiregion epigenomic rewiring in Alzheimer’s disease progression and cognitive resilience

A single-cell epigenomic and transcriptomic atlas across six brain regions in Alzheimer’s disease reveals widespread epigenomic relaxation and information loss, associated with the selective depletion...

cell.com

Excited to share that I was a guest on MS-Perspektive - The #MultipleSclerosis #Podcast with Nele von Horsten! 🎧 We had a great chat about the latest research in MS and how we're working to find new treatments. 💪 Listen to the full episode here 👇 ms-perspektive.com/129-luca-per...

Hope for Myelin Repair: Stem Cells & Progressive MS

Can neural stem cells support myelin repair and slow progression in MS? Dr. Luca Peruzzotti Jametti shares research, safety, and timelines.

ms-perspektive.com

www.nature.com/articles/s43... reproduced in vitro thanks to #FluidFM

MIRO2-mediated mitochondrial transfer from cancer cells induces cancer-associated fibroblast differentiation - Nature Cancer

Cangkrama et al. show that tumor cells from various cancer types use the mitochondrial trafficking protein MIRO2 and nanotubes to transfer mitochondria into surrounding fibroblasts, thereby inducing c...

nature.com

PERSPECTIVE | W Wu, H Chen et al. (Wash U St Louis) An overview of historical and more recent approaches for the induction of synthetic torpor and their potential medical application https://bit.ly/4mBb9FF ?utm_source=bluesky&utm_medium=social_&utm_campaign=natmetab

Synthetic torpor: advancing metabolic regulation for medical innovations - Nature Metabolism

Chen et al. provide an overview of historical and more recent approaches for the induction of synthetic torpor, and discuss their potential medical applications.

bit.ly

Beyond understanding the #brain, our goal is to heal it! www.lpjlab.org/news-1/8dgsijj0s02907evez1bmai1fht6pa Join us on September 10-11 at the 8th #Cambridge #Neuroscience Symposium to explore the latest breakthroughs that are poised to transform #patient care! Register here: tinyurl.com/27rzs5ku

The debate on intercellular mitochondrial transfer is heating up! In this new Viewpoint, eminent scientists in the field of mitochondrial biology, including our friend @rubenqc-lab.bsky.social, share their views on the topic. Dive in and let us know what you think! www.nature.com/articles/s42...