Fantastic interview with Dr. Rafaela Andrade, a former PhD student from my lab who went on to build a multimillion dollar biotech company focused on muscle health. Mentorship matters. thisisepigenetics.podbean.com/e/interview-...

Happy Birthday Canada.

❤️🇨🇦🇨🇦🇨🇦🇨🇦🇨🇦⚽

This level of energy input is not for the weak.

LKB1 loss suppresses estrogen, progesterone, and androgen signalling pathways, and that HLA-DRB5 is consistently downregulated across all STK11-mutated subtypes, suggesting an immune evasion component. A lot going on beyond the canonical AMPK-mTOR axis.

Paola A. Marignani@pmarignani.bsky.social · last mo.

Preprint from marignanilab.com. LKB1 isn't just a tumour suppressor kinase with metabolic function; there's more😁. We used scRNAseq, CRISPR, patient tumours, METABRIC genomics & new mouse model to ask:what is the impact of losing LKB1 expression on breast cancer? www.biorxiv.org/content/10.6...

Preprint from marignanilab.com. LKB1 isn't just a tumour suppressor kinase with metabolic function; there's more😁. We used scRNAseq, CRISPR, patient tumours, METABRIC genomics & new mouse model to ask:what is the impact of losing LKB1 expression on breast cancer? www.biorxiv.org/content/10.6...

🌞☕🏃🏻‍♀️

.....perfect balance of protein, lipids and carbs! #bibimbap

🌤️☕👩🏻‍💻 Spatial distribution of the proteome in the human body and in cancers. The authors present a comprehensive human proteomic landscape, by profiling>13,000 proteins across 2,856 samples. Dataset spans 58 major tissue types, 251 specific tissue subtypes and 25 distinct carcinomas. t.co/GxtrlhTjMb

....slowly easing back into climbing....very slow. Just getting here took some time. Goal: climb midway with controlled descent. Aim1. Put climbing shoes on Aim2. Chalk up hands Aim3. Just do it.

There is still time to register for Hot Topics in Basic and Translational Science @iaslc.bsky.social in Dublin, Ireland, June 26-27, 2026! ht26-iaslc.eventsair.site

I am deeply honoured to receive the Alumni of Distinction Award for Excellence in Basic Science Research, Schulich School of Medicine and Dentistry 2026- Western University www.schulich.uwo.ca/about/news-e...

Alumni of Distinction Awards celebrate impact and leadership - Schulich School of Medicine & Dentistry - Western University

This year’s six honourees exemplify excellence, with meaningful contributions across their professions and communities.

schulich.uwo.ca

🌞☕👩🏻‍💻 Organ aging signatures in the plasma proteome track health and disease. 😳🤔 www.nature.com/articles/s41...

Organ aging signatures in the plasma proteome track health and disease - Nature

Blood plasma protein data was combined with machine learning models for a simple method to determine differences in organ-specific aging; the study provides a basis for the prediction of diseases and ...

nature.com

Today, April 25th, my family commemorates Festa della Liberazione. 🇮🇹 1945, the Italian Resistance, and Allied forces, liberated Italia from fascist dictatorship and Nazi occupation. We honor the courage of the Marchigiani partigiani who fought for the liberty Italy enjoys tod #25Aprile #Italy

🌨️☕👩🏻‍💻 link.springer.com/article/10.1...

Minute amounts of helicase-deficient truncated RECQL4 are sufficient for DNA replication - EMBO Reports

RECQL4, a RecQ family helicase, is essential for DNA replication and genome stability. Mutations in RECQL4 cause severe human disorders yet we do not fully understand its functions, particularly regar...

link.springer.com

Welcome back Earthlings👽😁🧑🏻‍🚀👨🏾‍🚀👨🏻‍🚀👨🏻‍🚀🚀🛸🌑

NASA | ESA Space Updates@nasaupdates.bsky.social · 4mo ago

#Artemis II - Mission Complete! 🚀🌕🌍 Welcome Home Orion Crew! All four astronauts have now been extracted from the Orion Spacecraft

,🌞☕👩🏻‍💻 Chromosome 15q15 Deletion Drives Brain Metastasis in NSCLC - Journal of Thoracic Oncology www.jto.org/article/S155...

Chromosome 15q15 Deletion Drives Brain Metastasis in NSCLC

Brain metastasis (BM) is a devastating complication of NSCLC, particularly in NSCLC tumors harboring EGFR mutations. However, the genomic alterations driving BM remain poorly understood.

jto.org

🌞☕👩🏻‍💻 Landscape and functional impact of variants of unknown significance of immune response genes in human cancer. www.linkedin.com/safety/go/?u...

#ChristinaKoch, first #Woman in history to the moon. Talk about breaking barriers. @cdnwomenstem.bsky.social #CDNWomenSTEM congratulates the little girl that had a big dream and the woman that fulfilled that dream. #STEMWomen #LeadByLifting 🚀🌘👩🏻‍🚀🫰🏻

🚀 History is happening. For the 1st time in 53yrs, humans are on their way to the Moon. NASA's #ArtemisII crew; Commander Reid Wiseman, Pilot Victor Glover, Mission Specialist Christina Koch, and 🇨🇦 astronaut Jeremy Hansen have lifted off aboard the Orion #NASA #Artemis #SpaceExploration #Moon

There is always room for Bibimbap.

💨☕👩‍💻Excited to share our recent discovery. Tumour suppressors LKB1 and SMARCA4 working together to regulate gene expression, acting as a nexus between metabolism and chromatin remodelling. #LungCancer #CancerResearch #Epigenetics #Metabolism #LKB1 #SMARCA4 www.frontiersin.org/journals/cel...

Frontiers | Tumor suppressors LKB1 and SMARCA4 functionally interact to regulate gene expression across diverse biological processes in lung cancer

IntroductionThe tumor suppressor kinase liver kinase B1 (LKB1) is known to regulate the activity of the metabolic sensor AMP-activated protein kinase (AMPK),...

frontiersin.org

What do Signal Transduction, Neural Networks, Artificial Intelligence and Agentics, all have in common? COMMUNICATION. Join us at @dalhousie.bsky.social for an afternoon of science, technology and Guglielmo Marconi. events.dal.ca/medicine/eve...

Please join us on March 11th to celebrate the Evolution of Communication: Marconi to Agentic AI. Faculty of Medicine,Tupper Medical Bldg,Theatre A,4pm. Welcome Italian Ambassador to Canada H.E Alessandro Cattaneo to @dalhousieu.bsky.social @dalhousie.bsky.social 🇨🇦🇮🇹 Open to our Halifax community.

Happy International Women's Day! Today, I am celebrating the incredible strength, resilience, and achievements of women that lift me. In a world facing instability, it's women and girls who are often most affected, facing increased risks and deeper inequalities. #InternationalWomensDay #IWD2026

🌞☕👩🏻‍💻 Targeting amyloid-β pathology by chimeric antigen receptor astrocyte (CAR-A) therapy www.science.org/doi/10.1126/...

Targeting amyloid-β pathology by chimeric antigen receptor astrocyte (CAR-A) therapy

Alzheimer’s disease (AD) is the leading cause of dementia and is characterized by progressive amyloid accumulation followed by tau-mediated neurodegeneration. Despite advances in anti-amyloid immunoth...

science.org

At the end of the day.....of CIHR grant submission. 🎻

❄️☕👩🏻‍💻 🧐SCC demonstrates sensitivity with immunochemotherapy, but non-SCC, especially with KRAS+KEAP1/STK11 co-mutations, represents a distinct, immune-cold, high-risk subtype. www.jto.org/article/S155...

Neoadjuvant Immunochemotherapy in Resectable NSCLC With SMARCA4 Alterations

Neoadjuvant immunochemotherapy has improved pathologic complete response (pCR) rates and event-free survival in resectable NSCLC, yet its efficacy in SMARCA4-altered NSCLC, a subset associated with po...

jto.org

I have been asked by many of you to share my LinkedIn post regarding internal deadlines. Here you go. www.linkedin.com/posts/drpaol...

CIHR Funding Crisis: Canada's Health Research Community in Jeopardy | Paola Marignani PhD, EMBA posted on the topic | LinkedIn

The recent announcement of a 13.6% success rate (86.4% fail rate) for the Canadian Institutes of Health Research | Instituts de recherche en santé du Canada (CIHR) Fall 2025 PG competition is a stark ...

linkedin.com

🌞☕👩🏻‍💻😶 Interbreeding between Neanderthals and modern humans was strongly sex biased. www.science.org/doi/10.1126/...

Interbreeding between Neanderthals and modern humans was strongly sex biased

Sex biases in admixture and other demographic processes are recurrent features throughout human evolution. For admixture between Neanderthals and anatomically modern humans (AMHs), sex bias has been p...

science.org