SMARCA4, STK11, and KEAP1 co-inactivation associates with poor prognosis and upregulation of the TGF-β pathway in lung adenocarcinoma https://www.biorxiv.org/content/10.64898/2026.06.03.729911v1
LKB1 (STK11)
@stk11.bsky.social
🎙️ Live, from 19p13, it's Saturday Night! https://en.wikipedia.org/wiki/LKB1
LKB1 loss suppresses estrogen, progesterone, and androgen signalling pathways, and that HLA-DRB5 is consistently downregulated across all STK11-mutated subtypes, suggesting an immune evasion component. A lot going on beyond the canonical AMPK-mTOR axis. www.biorxiv.org/content/10.6...
Multiomic profiling of LKB1 loss of expression in breast cancer
The tumour suppressor LKB1 (STK11) is implicated in diverse cancers, yet its transcriptomic role in breast cancer remains poorly defined. Here, we integrate bulk-tumour genomic analysis of the METABRI...
biorxiv.org
LKB1 loss suppresses estrogen, progesterone, and androgen signalling pathways, and that HLA-DRB5 is consistently downregulated across all STK11-mutated subtypes, suggesting an immune evasion component. A lot going on beyond the canonical AMPK-mTOR axis.
Paola A. Marignani@pmarignani.bsky.social · last mo.Preprint from marignanilab.com. LKB1 isn't just a tumour suppressor kinase with metabolic function; there's more😁. We used scRNAseq, CRISPR, patient tumours, METABRIC genomics & new mouse model to ask:what is the impact of losing LKB1 expression on breast cancer? www.biorxiv.org/content/10.6...
Please RP! Excited to share our new preprint: “Single-cell chromatin tracing reveals multimodal molecular programs during memory formation” We built a single-cell multiomic atlas of aversive learning and used it to trace memory-linked molecular programs. doi.org/10.64898/202...
STK11/KEAP1 Advanced/Metastatic Squamous NSCLC algorithm from Drs. Charu Aggarwal and Ben Bleiberg @pennmedicine.bsky.social: myopenmedicine.com/algorithms/s...
STK11/KEAP1 Advanced/Metastatic Squamous NSCLC
The algorithm is partially aligned with current metastatic squamous NSCLC practice in its emphasis on broad molecular testing and guideline-directed targeted therapy when actionable drivers are presen...
myopenmedicine.com
pubmed.ncbi.nlm.nih.gov/42286854/ New paper in Cancer Reports: Scholl et al. genetically and pharmacologically profiled 20 cervical cancer cell lines against 34 clinically used drugs to identify candidate biomarkers for treatment response or resistance. 🧵
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pubmed.ncbi.nlm.nih.gov
PRMT5-mediated methylation of LKB1 controls PD-L1 expression in NSCLC. PRMT5 modulates PD‑L1 via the LKB1–AMPK axis in NSCLC, shaping #immunotherapy response & offering a biomarker‑guided strategy. www.sciencedirect.com/science/arti... #OpenAccess #MedSky
Garlic-derived metabolite activates LKB1, promotes adipose eNAMPT secretion, and improves age-related muscle function via hypothalamic signaling: Cell Metabolism www.cell.com/cell-metabol...
Garlic-derived metabolite activates LKB1, promotes adipose eNAMPT secretion, and improves age-related muscle function via hypothalamic signaling
Suzuki and Yoshioka et al. show that the garlic-derived metabolite S-1-propenyl-L-cysteine (S1PC) increases circulating eNAMPT, a key NAD+ biosynthetic enzyme, in mice and humans by activating a criti...
cell.com
#LKB1 loss in alveolar epithelial cells reduces #autophagy, induces #EMT, and drives #PulmonaryFibrosis via epithelial–fibroblast crosstalk, highlighting CAB39L‑LKB1 signaling as a potential therapeutic target in IPF. @unisouthampton.bsky.social #OpenAccess: doi.org/10.1016/j.ge...
LKB1 acts as a nexus between metabolism and gene expression, acting via the SMARCA4-SWI/SNF complex to regulate gene expression in lung cancer. New in @frontiersmedia.bsky.social doi.org/10.3389/fcel...
Frontiers | Tumor suppressors LKB1 and SMARCA4 functionally interact to regulate gene expression across diverse biological processes in lung cancer
IntroductionThe tumor suppressor kinase liver kinase B1 (LKB1) is known to regulate the activity of the metabolic sensor AMP-activated protein kinase (AMPK),...
doi.org
🔥 Hot paper from new investigators reveals that LKB1 mono- and bi-allelic loss increasingly reprograms the intestinal epithelium into a regenerative state characterized by autocrine EGF signaling and a predisposition towards serrated #ColorectalCancer development. 🔗 https://ow.ly/aXBj50Yfhem
CIHR funding rate: 13.6%. Early 2000s: 30%+. Canada’s new $1.7B Impact+ program recruits talent — but without increased Tri-Council base funding, we risk further strain on an already stretched system. We’re calling for $1B over 5 years. Support here: tinyurl.com/33c5av46
15% of LUAD lacked TTF-1 expression -> lower PD-L1 & more frequent KRAS and high-risk mutations, such as STK11, KEAP1, & SMARCA4 -> TTF-1 negativity stratified outcomes even among pts with high-risk mutations
TTF-1 expression in lung adenocarcinoma: clinicopathologic, genomic, and immunophenotypic correlates and outcomes to immunotherapy-based treatments and KRASG12C inhibitors
Thyroid transcription factor-1 (TTF-1) expression, routinely assessed through immunohistochemistry (IHC) in the diagnostic evaluation of lung adenocarcinomas (LUAD), is negative (TTF-1Neg) in ∼15-20% ...
jto.org
Proanthocyanidins enhance antitumor immunity by promoting ubiquitin-proteasomal PD-L1 degradation via stabilization of LKB1 and SYVN1 @jci.org www.jci.org/articles/vie...
This preprint maps synthetic lethal (SL) targets across 15 common cancer drivers using genome-wide CRISPR KO screens in isogenic cell line pairs plus a large-scale comparison to DepMap. www.biorxiv.org/content/10.6...
biorxiv.org
What if “undruggable” cancer drivers are druggable indirectly? New bioRxiv preprint: 15 CRISPR synthetic lethality screens + DepMap, then validation with clonogenic assays counted on GelCount. ARID1A→GFPT1, STK11→MARK2, FBXW7→PKMYT1. Read here: www.biorxiv.org/content/10.6...
biorxiv.org
Well, I don’t know what to say here. Discuss… @cashwood.proteaglyco.com pubs.acs.org/doi/10.1021/...
Vibe Coding Omics Data Analysis Applications
Building custom data analysis platforms has traditionally required extensive software engineering expertise, limiting access for many researchers. Here, I demonstrate that modern large language models...
pubs.acs.org
After a long review process, I'm excited that our paper is finally in print: www.cell.com/cell/fulltex... TL;DR: We use CRISPR screens in iPSC-derived neurons to find a new tau E3 ligase and a relationship between oxidative stress, the proteasome, and tau proteolytic fragments. More below 👇
CRISPR screens in iPSC-derived neurons reveal principles of tau proteostasis
CRISPR screens in iPSC-derived neurons reveal that the E3 ubiquitin ligase CRL5SOCS4 ubiquitinates tau, that CUL5 expression is correlated with resilience in human Alzheimer’s disease, and that electr...
cell.com
As generalized before, most cancer promoting genes are enriched in embryonic neural/neural stemness cells, incl. KRAS/HER2/EGFR/STAT3. They confer cancer cell with neural stemness, which determines tumorigenicity&pluripotency in cells. @pnas.org www.pnas.org/doi/10.1073/...
A targeted combination therapy achieves effective pancreatic cancer regression and prevents tumor resistance | PNAS
Pancreatic ductal adenocarcinoma (PDAC) has one of the lowest cancer survival rates. Recent studies using RAS inhibitors have opened the door to mo...
pnas.org
STK11 mutations and deletions define a distinct subtype of cervical adenocarcinoma https://www.medrxiv.org/content/10.64898/2026.01.01.25343162v1
Tumour suppressors LKB1 and SMARCA4 functionally interact to regulate gene expression of diverse biological processes in lung cancer https://www.biorxiv.org/content/10.64898/2026.01.26.699134v1
theconversation.com/ai-disruptio... The knowledge factory model is outdated and ill-suited to meaningful learning. In this form of education, generative AI technologies will increasingly outperform students.
AI disruptions reveal the folly of clinging to an idealized modern university
Alternative educational movements offer insights about how to help university students find purpose and hope as they navigate an increasingly complex world.
theconversation.com
This review examines the roles of #LKB1/STK11 in #cancer, detailing its #TumorSuppressive functions, regulation via #AMPK signaling and #AdaptorProteins, and discusses the challenges of developing LKB1-targeted inhibitors. @westernu.bsky.social #OpenAccess: doi.org/10.1016/j.ge...
Critical role for a high-plasticity cell state in lung cancer @nature.com @mskcancercenter.bsky.social www.nature.com/articles/s41...
Academic publishing is now one of the most lucrative industries per unit of input theconversation.com/when-science...
When science discourages correction: How publishers profit from mistakes
Academic publishing system often allows scientific errors to persist because it prioritises profit and prestige over timely correction.
theconversation.com
Single-cell RNA-seq is younger than the iPhone. 🤯 The first bona fide scRNA-seq transcriptomes were published in 2009 by Tang et al., who sequenced individual mouse cells and showed you could capture a whole transcriptome from a single cell. From “sci-fi” to standard tool in just over a decade...
www.frontiersin.org/journals/cel... Review: "The Tumor Suppressor Kinase LKB1: Metabolic Nexus" LKB1 loss is associated with multiple malignancies and causes metabolic reprograming to increase glycolysis and lactate production, elevate hexosamine biosynthesis and glutamine metabolism.
