New paper in @cp-cellreports.bsky.social where we mapped out the interactions between the microbes that live in the human gut and your repertoire of T-cells, which defend against cancer and infection! doi.org/10.1016/j.ce...
Pieter Meysman
@pmeysman.bsky.social
Professor in biomedical data science at the University of Antwerp. Part-time CTO of ImmuneWatch. Immunoinformatics with a focus on T-cell receptors.
Modern cancer immunotherapies are highly personal, tuned to a specific individual. Highly effective and extremely cool, but how do we do quality control on something that is unique? What if we combined ever cheaper NGS with state-of-the art annotation tools? www.sciencedirect.com/science/arti...
Applications of T-cell receptor specificity annotation models for quality control and immunomonitoring in adoptive T-cell therapies
Adoptive cell therapy (ACT) with tumor-infiltrating lymphocytes (TIL) is a powerful candidate immunotherapy. However, the personalized production proc…
sciencedirect.com
How effective were SARS-CoV-2 vaccines in inducing an immune response in blood cancer patients? And what lessons can we learn for future vaccination programs? (Hint: Antibodies aren't the full story) www.frontiersin.org/journals/imm...
Frontiers | CORSA study finds spike-specific blunted immune responses in lymphoma patients after SARS-CoV-2 vaccine
IntroductionHematological patients are at higher risk of severe SARS-CoV-2 infection and exhibit impaired vaccine responses due to disease and therapy. Treat...
frontiersin.org
From an interesting workshop to an exciting review: What are the best practices to assess the immunogenicity of a novel therapy in silico? www.frontiersin.org/journals/imm...
Frontiers | Review: Application and opportunities for machine learning and artificial intelligence in preclinical immunogenicity risk assessment
The unwanted immune response to Biologic Therapies can result in anti-drug antibodies that complicate clinical development and may adversely affect patient o...
frontiersin.org
Excited to be at the ISLH conference today to talk about where we are with using TCR-epitope AI tools for hematology.
The preprint on IMMREP25 TCR-epitope prediction challenge is now out on preprint, which reveals that unseen epitopes remains an unsolved problem in the field! doi.org/10.64898/202...
doi.org
Annotating novel T-cell receptors with their epitopes is something that I have put a lot of thought into the past decade. So I was excited to help actually frame an opinion on the topic in a white paper with ImmuneWatch: www.immunewatch.com/news/white-p...
New White Paper: How Reliable Are Antigen-Specificity Annotations for T-Cell Receptors?
ImmuneWatch white paper examining the reliability of computational TCR-antigen specificity annotations, covering database matching, seen epitope algorithms, and the validation behind DETECT.
immunewatch.com
🚀 Registration is now OPEN for AIRR Community Meeting VIII: Decoding and Recoding Immunity! Join us June 8–11, 2026 at Yale University (USA) or attend virtually. 💸 Early-bird rates available until April 15! 🔗 Register: tinyurl.com/airrcmeeting8 #AIRRC8 #immunosky
AIRR Community Meeting VIII.
tinyurl.com
Excited to have contributed to this review on how new technologies - including immunopeptidomics and TCR sequencing - might finally break the deadlock on a #Leishmania vaccine with Paul Kaye and Wim Adriaensen: doi.org/10.1016/j.pt...
Redirecting
doi.org
For the latest episode of The Repertoire Room Podcast, I sat down with Samra Turajlic after her talk at The Festival of Genomics and Biodata. "We could only understand this because we were able to track the clones through TCR sequencing." Check it out on YouTube: www.youtube.com/watch?v=QnRd...
Multiomics and TCR Sequencing in Immunotherapy | Repertoire Room Ep. 5
YouTube video by ImmuneWatch
youtube.com
How can #AI help decode our #immune systems and help for next generation #diagnostics? Here is a technical overview from the @airr-community.bsky.social diagnostics working group on where we currently are on this problem: doi.org/10.1016/j.im...
Redirecting
doi.org
Very proud to have been a jury member at the newly revived @iscb.bsky.social RSG Belgium hackathon! Exciting to see so many people giving their best efforts tackling challenging #bioinformatics problems!
The AIRR Diagnostics WG commentary is now available, wherein our members discuss both the challenges of current #AIRR-based #diagnostics, as well as the future directions that we see the field going into! www.sciencedirect.com/science/arti...
Challenges and Future Directions of AIRR-seq-Based Diagnostics
Adaptive Immune Receptor Repertoire sequencing (AIRR-seq) is a promising diagnostic method across various clinical conditions, yet its widespread impl…
sciencedirect.com
That's it. #ATCR25 is over! Thanks again to all attendees, speakers and support staff for making this an amazing meeting!
Fifth speaker, #ATCR25 day 2: Encarnita Mariotti-Ferrandiz on TCR repertoire signatures in auto immune and infectious disease.
Third speaker, #ATCR25 day 2, Soumya Raychaudhuri on how the HLA affects the TCR repertoire, and how the TCR affects cell fate.
#ATCR25 short talk 8: Nicole Mifsud on the immune signatures of alloreactive T cells during transplantation rejection.
#ATCR25 short talk 7: Vincent Van Deuren on using TRIASSIC to identify convergent TCR clusters in the synovial fluid of rheumatoid arthritis patients.
#ATCR25 short talk 6: Orian Bricard on using TWISTAR to identify cognate cancer epitopes of a TCR of interest.
#ATCR25 short talk 5: Giancarlo Croce on using phage display screening to identify cancer-specific TCRs at the epitope level.
#ATCR25 short talk 3: Bjorn Kwee on the possibility that TCR-epitope prediction is poor because the underlying data has more false positives than commonly believed.
#ATCR25 short talk 2: Abi Colley on building a TCR-epitope data set capturing variability on both the TCR and epitope side to build an annotation model.
Fifth #ATCR25 speaker: @kischober.bsky.social on how T cell receptor avidity influences clonal expansion following antigen exposure in a "natural experiment" (vaccination)
