Sander Wuyts, PhD 🧬
@swuyts.bsky.social
Helping scientists find the epitope specificity of their T-cell receptors at @immunewatch.bsky.social (www.immunewatch.com) Scientist on an entrepreneurial journey PhD in bioinformatics and microbiology Ex-Bork (EMBL) and Lebeer lab
I'll be honest, I wish I wrote this paper on the interface of microbiome and TCR seq 🫣 linkinghub.elsevier.com/retrieve/pii... On the positive, note: it features ImmuneWatch DETECT, so can't complain 😀 cc @pmeysman.bsky.social
Redirecting
linkinghub.elsevier.com
I thought I'd never publish again when transitioning from postdoc to startup founder. Today we proved that wrong as I am happy to share our latest @immunewatch.bsky.social paper on applying TCR-epitope models for TIL-therapy together with Harari and Coukos: www.sciencedirect.com/science/arti...
Modern cancer immunotherapies are highly personal, tuned to a specific individual. Highly effective and extremely cool, but how do we do quality control on something that is unique? What if we combined ever cheaper NGS with state-of-the art annotation tools? www.sciencedirect.com/science/arti...
Applications of T-cell receptor specificity annotation models for quality control and immunomonitoring in adoptive T-cell therapies
Adoptive cell therapy (ACT) with tumor-infiltrating lymphocytes (TIL) is a powerful candidate immunotherapy. However, the personalized production proc…
sciencedirect.com
We're testing something new: access ImmuneWatch DETECT through an MCP integration with Claude. Let me know if you'd like to try it out: xvx5k3zru3y.typeform.com/to/Wq7egCwo
The Microbe Atlas database paper is *finally* published! Out in @cellpress.bsky.social today: www.sciencedirect.com/science/arti...
The MicrobeAtlas database: Global trends and insights into Earth’s microbial ecosystems
Environmental DNA sequencing has revolutionized our understanding of microbial diversity and ecology. Microbiomes have now been sequenced across the e…
sciencedirect.com
For the latest episode of The Repertoire Room Podcast, I sat down with Samra Turajlic after her talk at The Festival of Genomics and Biodata. "We could only understand this because we were able to track the clones through TCR sequencing." Check it out on YouTube: www.youtube.com/watch?v=QnRd...
Multiomics and TCR Sequencing in Immunotherapy | Repertoire Room Ep. 5
YouTube video by ImmuneWatch
youtube.com
Is it possible that in the newest update of Spotify, I can not switch from VIDEO mode to AUDIO only mode anymore? I used to be able to switch very easily and now it seems some button disappeared as I just can't figure it out. Super annoying
I'll be in London at the festival of Genomics later this week. Hit me up if you want to connect!
One of my favourite pics of Peer. Took this one on a summer day in 2021 during a lab get-to-together at his place. Cheer to you too Peer. #PeerBork
Sander Wuyts, PhD 🧬@swuyts.bsky.social · 7mo agoI can not believe this news. The EMBL community, microbiome field and bioinformatics in general loses a legend 😢 www.embl.org/news/embl-an...
For many years, Peer Bork organised Bio-IT retreats to bring together the bioinformaticians across EMBL, in Garmisch-Partenkirchen and later Feldberg. Days out on the mountain followed by forward-looking and meta-science oriented sessions in the hut that fueled many projects and careers.
I can not believe this news. The EMBL community, microbiome field and bioinformatics in general loses a legend 😢 www.embl.org/news/embl-an...
In remembrance of Peer Bork | EMBL
EMBL and its community are deeply saddened by the death of Peer Bork, the organisation’s Interim Director General.
embl.org
I'll bee in London at the end of the month for the Festival of Genomics. Who can I run into?
Any TCR-seq folk attending Festival of Genomics in London? festivalofgenomics.com/london
Finding the putative target of a TCR is hard! But I am really excited to see that innovative cancer therapy companies like Obsidian Therapeutics are getting some real value out of using our database + machine learning algorithm.
Crazy excited about Jack White being on tour again! He was just announced headlining Best Kept Secret festival in the NL 🥳
Episode 3 of “The Repertoire Room” has just been released! After 2 episodes with technology providers in the TCR sequencing space, I now wanted to have a conversation with someone that was really using these technologies to push innovative therapies to patients. Enter: @armanaksoy.bsky.social
This might end up in the void, but is ESMO IO worth attending?
If you asked me 10 years ago, I wouldn't have guessed that I would ever give a guest lecture on "Innovation and Entrepreneurship" Talks about microbiology, sequencing technologies, gene editing technologies, fermentation or bioinformatics: yes. But Entrepreneurship, nah :)
Tonight at a public meeting I clapped when everyone else was murmuring in fear and worry about the idea of reducing the number of lanes on a road in order to accommodate wider sidewalks and bike lanes. Definitely an outlier.
Brent Toderian@brenttoderian.bsky.social · 10mo agoI don’t hate cars. Like most North American males I was raised to think cars are cool, and as a design nerd, few objects are more eye-catching. I hate surrendering our streets, our cities and our lives to them. Car dependence isn’t freedom. Great cartoon by @robcowan.bsky.social #CarDependency
Always curious whether this new update will bring new insights for you!
ImmuneWatch@immunewatch.bsky.social · 10mo agoWe committed ourselves to push new TCR-epitope data to our database every quarter. Last week we published a new version of ImmuneWatch DETECT with TCRs for 75 different epitopes, of which 49 were not yet in our database. Many new HPV epitopes! immunewatch.gitlab.io/detect-docs/...
Episode 2 of my podcast, the Repertoire Room is live! In this podcast I hope to have insightful conversations with people working on TCR sequencing and analysis. Now I sat down with the developer of one of the most used tools in the field: MiXCR www.immunewatch.com/news/podcast...
Podcast: The Repertoire Room - Episode 2 featuring Stanislav Poslavsky (MiLaboratories)
immunewatch.com
Never thought I was going to post something like this on our Slack but after submitting some EU-grants it felt like the right thing to do 😂
From now on, my reading stats and recaps will be incorrect for eternity.
We are looking for a postdoc to study single-cell transcriptional heterogeneity in the human skin microbiome. We have a new protocol mostly developed, but need someone to see it through. Experience with protocol dev or RNAseq appreciated. Funded by a new grant from MIT-HEALS.
Het aantal verkeersdoden in een land en stad is een politieke keuze. Geen technische. Dit is oud nieuws en al heel lang bekend. Doe wat Helsinki en Oslo doen die al jarenlang nul verkeersdoden hebben. Bange politici weigeren de automobilist aan te pakken.
Recently I learnt that EMBL-EBI has a free online course about AlphaFold — how it works, strengths and limitations, how to use it — and it's very good! There are also little quizzes and interactives. www.ebi.ac.uk/training/onl...
AlphaFold - A practical guide
AlphaFold - A practical guide
ebi.ac.uk
First day of #ATCR25 in Antwerp: done ☑️ 🤩 Picture of Antwerp city station #immunology #TCRrepertoire #Tcells #research
