Paul Norman

@pn0rmski.bsky.social

Immunology (still not in mice)

'Superresolution microscopy has revealed a nanoscale rearrangement of NK cell receptors at the cell surface upon cellular activation. An emerging idea is that the activation and inhibition of immune cells is influenced by the nanoscale proximities of receptor clusters' www.pnas.org/doi/10.1073/...

Nanoscale restructuring of the immune synapse with an engager enhances NK cell function | PNAS

Engagers are antibody-based therapies which bind immune cell receptors and a target cell ligand. Next-gen engagers typically bind two activating re...

pnas.org