Interesting role for m6A in RNA processing! www.nature.com/articles/s41...

Aberrant splicing in Huntington’s disease accompanies disrupted TDP-43 activity and altered m6A RNA modification - Nature Neuroscience

Nguyen et al. identify TDP-43 and METTL3 as key regulators of disrupted RNA splicing in Huntington’s disease, offering insight into how TDP-43 mislocalization and aberrant m6A RNA modification and loc...

nature.com

Awesome resource for #childhoodcancer researchers from @kentsisresearch.bsky.social !

Kentsis Research Group@kentsisresearch.bsky.social · 2y ago

Great to see "Developmental Oncology: Principles and Therapy of Cancers of Children and Young Adults" with Alejandro Gutierrez and many co-authors coming out from CSHL Press www.cshlpress.com/default.tpl?...

Why can a human tolerate a drug that globally inhibits transcription? Why do transcription inhibitors not cure cancer? Our first paper of 2025 may help explain (some) of this! So incredibly proud of @tobiaswilliams.bsky.social & Ewa Michalak who led the work! www.cell.com/molecular-ce...

mRNA export factors store nascent transcripts within nuclear speckles as an adaptive response to transient global inhibition of transcription

Transcription inhibitors also disrupt nuclear export. Here, Williams et al. reveal that mRNA export factors sense transcription inhibition and adapt by storing mature export-competent mRNA in nuclear speckles. This enables rapid release when transcription resumes and ensures retention of cellular identity and viability during a transient global transcription insult.

cell.com

Learn more about Molecular Mechanisms in RNA Biology with this joint collection of the latest Reviews and Perspectives from @CellChemBiol and @MolecularCell http://dlvr.it/TH4dtW

Do you know where transcription of a gene actually stops? Hint: it is not the annotated gene end. In our new paper in Nucleic Acids Research we argue that phosphorylation on threonine 4 of RNA Pol II CTD is a marker of transcription termination in animals... 🧵 academic.oup.com/nar/advance-...

www.sciencedirect.com/science/arti...

Created a starter pack to grow the pediatric neuro oncology community here! go.bsky.app/VTHk2qy

There are more ways to design an mRNA than atoms in the universe, so how do you choose the best one? Our new @basemrna.bsky.social software, mRNArchitect enables you to tune expression, stability, reactogenicity and synthesisability to design more potent #mRNA drugs. www.biorxiv.org/content/10.1...

mRNArchitect: optimized design of mRNA sequences

Summary: mRNA design is the critical first step in the development of a new vaccine or therapy. The mRNA primary sequence is assembled from multiple elements, including the coding sequence of the targ...

biorxiv.org

So cool!

Olivier Duss@olivierduss.bsky.social · 2y ago

First paper of our lab today @natureportfolio.bsky.social by Nussi! We provide a real-time movie on how #transcription and #translation cooperate using #single-molecule FM: we find long-range #ribosome/ RNAP communication mediated by #RNA looping! @embl.org #RNAbiology #RNASky t.co/a24Xxcxdo0

Nice paper from Jenn Prescher and colleagues on tags for bioluminescence imaging of RNAs. www.nature.com/articles/s41...

A modular platform for bioluminescent RNA tracking - Nature Communications

Studying RNA dynamics in vivo often relies on fluorogenic approaches, but these can be hampered by factors such as limited sensitivity and sample autofluorescence. Here, the authors describe an ultras...

nature.com

A special JMB issue on Transcription elongation and termination with really great reviews including @triggerloop.bsky.social @voslab.org @lucas.farnunglab.com www.sciencedirect.com/science/arti...

Controlling Transcription Elongation and Termination: More Than a Means to An End

sciencedirect.com

www.cell.com/current-biol... Sex differences in RNA biology. #RNASky

RNA helicases DDX3X and DDX3Y form nanometer-scale RNA-protein clusters that support catalytic activity

Yanas et al. report that RNA helicases DDX3X and DDX3X form nanometer-scale RNA-protein clusters (RPCs) both in vitro and in cells. Differences in RPC size and catalytic activity between DDX3X and DDX...

cell.com

Time for Pediatric Cancer Starter Pack! go.bsky.app/2UbwR5L

Women are under-represented at senior levels in #academia globally, & across all #science 🧪 disciplines, as shown by these "scissor-shaped curves" ✂️ So how can we ever achieve #gender #equality? We discuss various strategies in this #Cell Commentary #WomeninSTEM www.cell.com/cell/fulltex... 🧵 1/

RNAkinet identifies nascent RNA by predicting 5EU metabolically labeled #RNA from raw #nanopore electrical signal. Should allow association of RNA metabolism dynamics with isoform usage, poly(A) tails and native RNA mods. academic.oup.com/nargab/artic...

How long does an mRNA stay in the nucleus? How long does it stay in the cytoplasm? In an amazing collaboration with @landthalerm.bsky.social, we used metabolic labeling, cell fractionation and mathematical modeling to quantify mRNA flow through the cell. Finally out in MSB: doi.org/10.1038/s443...

Would you prefer to lead a lab alone or together with a science buddy? How interesting would be a research institute where joint labs are the standard?!

Created a pediatric neuro oncology group. Please message to grow the community! go.bsky.app/VTHk2qy

Hi #RNAsky, I've made a much needed #RNA modifications starter pack! Let me know if you’d like to be added or know someone who should be. go.bsky.app/E7zXGSF #RNAmodifications

RNA modifications

Join the conversation

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Interesting role of m6A in the coding sequence of RNA www.cell.com/molecular-ce...

m6A sites in the coding region trigger translation-dependent mRNA decay

Zhou et al. discovered a specific role of adenosine modifications in the coding region of mRNAs. These chemical alterations slow down the movement of the ribosome during translation and trigger degrad...

cell.com

What a nice tool!

Anne Simon 🧪🌱🐴🦠🍊🇨🇦🇺🇦@annealiz1.bsky.social · 2y ago

#RNA #RNAsky Such a great RNA community being built here! Thought I’d introduce our wonderful RNA structure drawing app RNAcanvas. 100’s of daily users all over the world rna2drawer.app RNAcanvas: interactive drawing and exploration of nucleic acid structures academic.oup.com/nar/article/...

Check it out! The RNA Society 2025 Meeting Site is now live! Registration will open in January RNASociety Note the fabulous artwork by former EmoryBCDB student Dr. Carly Lancaster- make your plans now to join us in San Diego May 27-June 1, 2025