Nils Blüthgen
@molsysbio.bsky.social
Charité and Humboldt University Berlin, Computational Modelling, Cancer, Signaling
www.tagesspiegel.de/wirtschaft/f...
Fatale Signale für den Wirtschaftsstandort Hauptstadt: Die Gesundheitsreform schwächt vor allem Berlin
Warum aktuelle Sparmaßnahmen nicht nur Krankenhäuser belasten, sondern auch Forschung, Fachkräfte und Investitionen gefährden – und damit langfristig dem Wirtschaftsstandort schaden.
tagesspiegel.de
1. How common is LLM use in scientific publishing, and how does it vary across field, publisher, journal prestige, author demographics etc.? @kylesiler.bsky.social has new paper in PNAS that addresses this question on a massive scale: 7.3 million papers from Elsevier, PLOS, MDPI, and Frontiers.
The diffusion of large language models in published academic articles | PNAS
Large language models (LLMs) are rapidly changing academic research, raising questions of who is adopting these tools and under what conditions. Th...
pnas.org
Der Vorname des mutmaßlichen Täters, der Anlass für die Aktuelle Stunde im Bundestag „Gewalt gegen Frauen“ war, lautet übrigens: „Christian“.
Happy birthday to 🇨🇦Canadian medical researcher & #biochemist Maud Menten (1879-1960). 👩🏼🔬🧪🐡 #histsci Not only was she an author of Michaelis-Menten equation for enzyme kinetics, she invented the azo-dye coupling for alkaline phosphatase, 1st example of enzyme histochemistry, still used in imaging of
Chemist/physician Dr. Maud Menten co-authored the seminal paper 𝘋𝘪𝘦 𝘒𝘪𝘯𝘦𝘵𝘪𝘬 𝘥𝘦𝘳 𝘐𝘯𝘷𝘦𝘳𝘵𝘪𝘯𝘸𝘪𝘳𝘬𝘶𝘯𝘨, 1931. This intro'd the Michaelis–Menten equation (image). It remains a cornerstone of #biochemistry, used in drug design, metabolic studies & enzyme engineering. She was born #OTD in 1879. #WomenInSTEM
![A black-and-white historical photograph of Dr. Maud Leonora Menten (1879–1960), the Canadian physician and biochemist who co-developed the Michaelis–Menten equation for enzyme kinetics. Taken in her laboratory (likely at the University of Pittsburgh in the 1910s–1920s), she stands with a serious, focused expression—lips closed, eyes direct and thoughtful—against a backdrop of wooden shelves filled with glass bottles, jars, scientific equipment, and a wire-mesh enclosure. She wears a dark dress with a lace collar, a string of beads, and her hair styled in a neat bun. Superimposed on the image is the Michaelis–Menten equation in white text:v=Vmax[S]Km+[S]v = \frac{V_{\max} [S]}{K_m + [S]}v = \frac{V_{\max} [S]}{K_m + [S]}
This iconic portrait captures Menten during her groundbreaking research in biochemistry and histochemistry, where she helped establish the foundational mathematical model of enzyme-substrate reactions still used today, while overcoming significant gender barriers as one of the first women in Canada to earn both an M.D. and a Ph.D.](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:2xisupj43xdq7uvffzigis5p/bafkreihpw72tjmrypo7d5tc2fv5kzpsmsc7kglj4n3ekw22e2ys4gg6nti)
Thrilled to be at the 2nd Bonn conference on mathematical life sciences. Great to see a huge lecture hall full of people at the kickoff of the conference, all working at the interface of maths and biology.
Toll, dass die Berliner Behörden jetzt verstanden haben, wie Cell Broadcast grundsätzlich funktioniert, jetzt vielleicht noch ne Schulung zum sinnvollen Einsatz, danke.
Zell- & Molekularbiologin Kerstin Kaufmann wird Einstein-Prof & bleibt an der @humboldtuni.bsky.social! Durch Koops mit BIMSB, @mpi-mp-potsdam.bsky.social & @igzleibniz.bsky.social vernetzt sie Molekularbiologie, quantitative Modellierung & Bioengineering. www.einsteinfoundation.de/presse/2026/...
Der #Forschungsausschuss des Bundestags tagt nicht mehr öffentlich — das war’s dann mit Tranzparenz wissenschaftspolitischen Handelns auf Bundesebene! Erschwert die Arbeit von Journalist_innen ebenso wie unsere für #IchBinHanna uvm. massiv. @wpk.bsky.social fordert in 1 offenen Brief, das zu ändern:
Offener Brief an die Bundestagsfraktionen von CDU/CSU, SPD, Bündnis 90/Die Grünen und Die Linke zur Rückkehr der grundsätzlichen Öffentlichkeit der Sitzungen des Forschungsausschusses
An die Vorsitzenden der Bundestagsfraktionen von CDU/CSU, SPD, Bündnis 90/Die Grünen und Die Linke Berlin, 19.11.2025 Öffentlichkeit im Bundestagsausschuss für Forschung, Technologie, Raumfahrt und T...
wpk.org
Die Charité-Chefs haben am Montag im Berliner Wissenschaftsausschuss die Folgen der Kürzungen für die Uniklinik skizziert. "Drittmittel werden sinken, Ambulanzen müssen schließen“, fasste Dekan Joachim Spranger es zusammen. (T+) www.tagesspiegel.de/wissen/chari...
Charité-Chef Heyo Kroemer über Kürzungsfolgen: „Bei keinem Uniklinikum in Deutschland wird derart gespart“
56 Millionen Euro weniger Zuschüsse bekomme das Berliner Uniklinikum 2026, sagt Charité-Chef Kroemer. Das wird sich auf Berlins medizinische Versorgung auswirken – und könnte die Spitzenstellung in de...
tagesspiegel.de
Welcome our new colleagues: Prof. Flasche aus Ede and Prof. Geschirrschwämme! Looking forward to working with you!
I always wanted to join the editorial board for an agricultural journal. Clearly my expertise. Will be a great journal 🤡 #scientificspam
Berlin’s senate invests >12 mio EUR for 3 NFL games in Berlin, at a time where they cut millions at the universities that are already underfunded, with collapsing buildings. They definitely seems to have priorities that are not mine. www.tagesspiegel.de/berlin/senat...
Senat will 12,5 Millionen Euro investieren: NFL kommt 2025 für ein Spiel nach Berlin
Die nordamerikanische Football-Liga NFL wird 2025 ein Spiel in Berlin austragen. Bis 2029 könnten zwei weitere Folgen. Die Kosten dafür sind hoch. Das Land muss trotz Haushaltskrise Millionen investie...
tagesspiegel.de
“Stands out … for its contribution to the society in the field to finance”???? Maybe the most bizarre spam email I ever received…
⚠️ Paper alert: Using a novel CRISPR screening approach, we mapped the entire regulatory network controlling Xist—key for X-chromosome inactivation. 👉 We discover how sex and development signals are decoded at a single gene locus. www.nature.com/articles/s41... 👇 Bluetorial
Reporter CRISPR screens decipher cis-regulatory and trans-regulatory principles at the Xist locus - Nature Structural & Molecular Biology
Here Schwämmle et al. develop CRISPR reporter screens to map transcription-factor-regulatory element interactions at the Xist locus, revealing a two-step mechanism integrating developmental and X-dosage signals to initiate X-chromosome inactivation.
nature.com
When I was at NIH and shutdowns loomed, it was discovered that the administration was planning to shut down PubMed. The head of NCBI called the powers that be and pointed out that this would threaten patient safety Who knows what will happen now Just in case, remember Euruope-PMC (europepmc.org )
a cartoon of donald trump with the words be prepared above him
ALT: a cartoon of donald trump with the words be prepared above him
media.tenor.com
The Ärzteblatt asked me about the instability of Pubmed (Why my? Don't know...). Not sure if I agree with the colleagues that we should build up national resources, I rather think we should strengthen existing European ones (e.g. EuropePMC, ENA, EGA...)... www.aerzteblatt.de/archiv/wisse...
Wissenschaftliche Resilienz: Auf dem Weg aus der PubMed-Abhängigkeit – Deutsches Ärzteblatt
aerzteblatt.de
Nicky McGranahan kicking off the last day showing the evolutionary history of metastasis. Amazing data and analysis.
Very dynamic poster sessions at the late summer school on tumor heterogeneity and treatment followed by a rooftop party. Thank you @mdc-bimsb.bsky.social for hosting us!
Great talks from PhD students Tancredi Massimo Pentimalli, Adila Apsara: and Siddharth Annaldasula!
Efrat Shema kicking off today’s program with a lecture on epigenetics and single cell methods.
Final session for today: Sven Nelander discusses how patient specific models combined with advanced molecular biology and large scale computation allow for a better understanding of CNS cancers.
We continue with Ido Amit who shows how single cell approaches allow to improve immune therapy and Anton Henssen introducing us to the world of extrachromosomal DNA and how this relates to tumor heterogeneity. Fascinating!
First session: Uli Keilholz of the comprehensive cancer center on how complex data and models are now used in the clinics, and Heiko Enderling on modeling approaches. Both show excellent examples on how computation already now is impotent for clinical decisions, and how it will be in future.
Kicking off today’s Late Summer School on tumor heterogeneity and treatment resistance with an amazing program. Great to see a huge turnout!
Very harmonious and inspiring collaboration with Niels Gehring, @volkerboehm.bsky.social and team at Uni Köln, and colleagues at @mdc-berlin.bsky.social . Rapid UPF1 depletion illuminates the temporal dynamics of the NMD-regulated human transcriptome: Molecular Cell www.cell.com/molecular-ce...
Rapid UPF1 depletion illuminates the temporal dynamics of the NMD-regulated human transcriptome
UPF1 depletion inhibits nonsense-mediated mRNA decay (NMD) and stabilizes direct target transcripts within hours. Boehm et al. use conditional protein degradation and advanced transcriptomics to map t...
cell.com
Join us for our first CompCancer seminar this fall on Thursday, 4pm with Chris Sander (Harvard): „Catch Cancer Early with the Help of AI Tools“. Maud Menten Room, House 18, Campus Nord HU
