Come check out our poster tomorrow on whole-exome sequencing of colitis adverse events in patients treated with immune checkpoint inhibitors #AACR25 @ucsfcancer.bsky.social @mskcancercenter.bsky.social

Thrilled to share our work on investigating the role of a polygenic risk score for overall autoimmunity in cessation of immune checkpoint inhibitor therapy for toxicities. bit.ly/3E3NkoX @adamjschoenfeld.bsky.social @ucsfcancer.bsky.social @ucsfmedicine.bsky.social @mskcancercenter.bsky.social

Excited to share our latest work exploring the role of germline genetics in the development of multiple primary cancers @lindakachuri.bsky.social @jovia-n.bsky.social @johnwitte.bsky.social

Human Genetics and Genomics Advances@hggadvances.bsky.social · 2y ago

📣Online now! 📄Unraveling the genetic landscape of susceptibility to multiple primary #cancers 🧑‍🤝‍🧑@johnwitte.bsky.social @poojamiddha.bsky.social & co 👉https://bit.ly/3WPyzfG

Work by PhD student @jayatirsharma.bsky.social on how grouping Hispanic/Latino participants into a single group can obfuscate substantial substructure, leading to false conclusions. We show how heterogeneity by background group wrt genetic ancestry and environment can affect genetic risk models.

Jayati Sharma, PhD, ScM@jayatirsharma.bsky.social · 2y ago

New preprint! Within the HCHS/SOL study, we looked at the roles of self-identified background and genetic ancestry in describing GxE interactions of a PGS and sociocultural variables in a Hispanic/Latino population. www.medrxiv.org/content/10.1...

This paper was a long time coming, happy to see it out today in @naturecomms.bsky.social: www.nature.com/articles/s41... We found some interesting links between genetic regulation of blood cell traits and #glioma risk + survival, pointing to #immune related mechanisms 🧠🧬

Genetic predisposition to altered blood cell homeostasis is associated with glioma risk and survival - Nature Communications

Glioma is an aggressive brain tumor subtype with few known risk factors. Here, the authors utilise Mendelian Randomisation to investigate correlation of immune cell counts with subtype-specific risk a...

nature.com

As incoming chair of the young investigator committee of the International Genetic Epidemiology Society (IGES), I'd like to share a great opportunity for 5 Early Career Researchers to join the different IGES committees, deadline 31st Dec, details here: www.geneticepi.org/yic_position...

One of the most important multi-cancer analyses on #ImmuneRelatedAdverseEvent grading and clinical outcome is out this week from @JNCI : https://buff.ly/499OIBj

These people made it all possible: @supportingswog.bsky.social

Elad Sharon, MD, MPH@eladsharonmd.bsky.social · 2y ago

One of the most important multi-cancer analyses on #ImmuneRelatedAdverseEvent grading and clinical outcome is out this week from @JNCI : https://buff.ly/499OIBj

academic.oup.com/aje/article/... #episky #statsky #epidemiology #statistics

What is Machine Learning? A Primer for the Epidemiologist

Abstract. Machine learning is a branch of computer science that has the potential to transform epidemiologic sciences. Amid a growing focus on “Big Data,”

academic.oup.com

🎨 In case anyone need… The NIH BioArt Source is an awesome library of *free* professionally drawn illustrations for scientific presentations or figures. Downloadable in HD. Thank you NIH for this invaluable tool 🙏! Check it out 👇 bioart.niaid.nih.gov

In a new preprint led by @TheNikhilMilind, we explored a fascinating paradox: For many traits the number of duplications or loss-of-function (LoF) mutations is correlated with phenotype. Curiously, for most traits, the AVERAGE direction of LoFs and Dups is the SAME. Why?

Thrilled to see our work on genetic prediction of immune checkpoint inhibitor-mediated colitis published t.co/nsCV47ahwl

Polygenic risk score for ulcerative colitis predicts immune checkpoint inhibitor-mediated colitis - Nature Communications

Colitis is one of the most common immune-related adverse events in patients with cancer treated with immune checkpoint inhibitors. Here the authors show that a polygenic risk score for ulcerative coli...

t.co

Our isoTWAS work with the Pasaniuc and Gandal labs is out at Nature Genetics! Great team effort, especially from Daniel Vo and Connor Jops. Appreciate the helpful and thoughtful comments from reviewers that improved our work! www.nature.com/articles/s41...

Isoform-level transcriptome-wide association uncovers genetic risk mechanisms for neuropsychiatric d...

A multivariate framework for isoform-resolution transcriptome-wide association studies enables modeling of a greater number of genes, with the benefit of identifying isoform-specific associations with...

nature.com

I'm writing a molecular perspective on heritability, behavior, (and eventually) race/ancestry, group differences. The idea is to start with what we've learned from genetic data and then work backwards to what we used to know from classical studies. gusevlab.org/projects/hsq/

We’re back with a bigger and better GWAS of PSA levels! 🤩 We substantially increased sample size in African ancestry (+58k) and Hispanic/Latino (+23k) men, which translates into meaningful improvements in PRS performance www.medrxiv.org/content/10.1...

Trying to be better with sharing work on here 😅 Check out our paper that identifies novel immune-mediated risk factors for glioma. We also found interesting genetic associations with survival and features of the tumor immune microenvironment 🧬 🧠

medRxivpreprint@medrxivpreprint.bsky.social · 3y ago

Genetic predisposition to altered blood cell homeostasis is associated with glioma risk and survival https://www.medrxiv.org/content/10.1101/2023.10.15.23296448v1