David Puleo, Marina Nelen, Chinatsu Sakata, and Ryan Potts discussed "Degraders in the Era of Precision Oncology" in an #AACRdrugdev26 plenary session chaired by Danette Daniels. @danetteldaniels.bsky.social @pottslab.bsky.social
Ryan Potts - real
@pottslab.bsky.social
VP & Head of Induced Proximity Platform, @Amgen | Scientist | Father
A new #ScienceReview looks at a different approach to drug discovery that may enable drugging of unconventional targets through stabilization of macromolecular complexes with molecules known as “LOCKTACs.” Learn more: https://scim.ag/4lC2aCM
Check out how the Amgen Induced Proximity team repurpose lysosomal membrane proteins for targeted protein relocalization and degradation using LYMTAC molecules. Now published in @NatureComms. Congrats to @dnalawansha0509.bsky.social and team! #mycompany www.nature.com/articles/s41...
LYMTACs:chimeric small molecules repurpose lysosomal membrane proteins for target protein relocalization and degradation
Nature Communications - LYMTACs are heterobifunctional small molecules that take advantage of lysosomal membrane proteins to degrade membrane targets via relocalization and lysosomal degradation,...
nature.com
What if treating disease meant stabilizing biology, not blocking it? We explore that idea in @ScienceMagazine with LOCKTAC molecular glues, a new class of molecules that stabilize natural interactions to either boost or block biology. science.org/doi/10.1126/sc…shorturl.at/976aj #mycompnay
science.org
🎓 Recent STEM grad? Jump-start your PhD journey with Amgen’s new 2-yr paid Postbaccalaureate Research Fellowship in Thousand Oaks! Work with world-class scientists, publish your findings, and make a real impact for patients. Apply by July 15 ➡️ amgen.wd1.myworkdayjobs.com/Careers/job/...
Postbaccalaureate Fellow - Research
Career Category Research Job Description Join Amgen’s Mission of Serving Patients At Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission—to serve patients...
amgen.wd1.myworkdayjobs.com
Our latest paper w/ @pottslab.bsky.social & @amgen.bsky.social in @jacs.acspublications.org by co-first authors @cmzammit.bsky.social & Cory Nadel on discovery of covalent destabilizing degrader of AR & AR-V7 in prostate cancer. Thanks also to @themarkfdn.bsky.social ! pubs.acs.org/doi/10.1021/...
SCAM ALERT. This is a fake conference that ripped off my and other people’s names to trick people into registering. There is no such conference that I or the others shown were invited or agreed to. We are working to try to get this fraud taken down from the web. chemsymposia.com
Join Chemsymposia 2026: Research & Innovation | ChemSymposia 2026
Join us at Chemsymposia 2026 to discover groundbreaking research in physics applications. Connect with experts, engage in insightful discussions, and explore our venue, registration details, and speak...
chemsymposia.com
.@pottslab.bsky.social @amgen.bsky.social demonstrate proof-of-concept of disease-specific targeted degradation by redirecting virally encoded E3 ubiquitin ligases with VIPER-TACs. http://dlvr.it/TJgF0r
🚨 Rational discovery of VHL molecular glues. New Preprint from @amgen.bsky.social Induced Proximity group led by postdoc Jonathan Bushman reports the discovery of a VHL molecular glue degrader of GEMIN3 by Picowell RNA-seq. Read on for details. 🧵1/8 www.biorxiv.org/content/10.1...
Discovery of a VHL molecular glue degrader of GEMIN3 by Picowell RNA-seq
Targeted protein degradation (TPD) is an emerging therapeutic modality in which small molecules are used to recruit targets to the natural protein degradation machinery of the cell. Molecular glue deg...
biorxiv.org
Check out this cover highlighting @amgen.bsky.social postdoc Kyle Mangano’s work on VIPER-TACs! 🐍
Cell Chemical Biology@cp-cellchembiol.bsky.social · last yr.The March issue of Cell Chemical Biology is out! Click here to read it: #condensates #ferroptosis #lipids #VIPER-TACs #PRDX #ergothioneine #proximity #syntheticbio http://dlvr.it/TJfCD8
Thrilled to share the structure of dimerised human PINK1 docked to an endogenous translocase array on the mitochondrial surface, composed of two TOM complexes, bridged by a VDAC2 dimer! Published today in Science www.science.org/doi/10.1126/... @wehi-research.bsky.social @komanderlab.bsky.social
New report shows that NIH grants fueled $95 billion in economic activity and 407,782 jobs in 2024. That's not to mention the countless lives that biomedical research has saved. Show me a better investment than that. www.forbes.com/sites/michae...
NIH Grants Fueled $95 Billion In FY 2024 Economic Activity, Finds New Report
National Institutes of Health grants generated almost $95 billion in economic activity nationwide in FY 2024 according to a new report by United for Medical Research.
forbes.com
Online now! @pottslab.bsky.social @amgen.bsky.social demonstrate proof-of-concept of disease-specific targeted degradation by redirecting virally encoded E3 ubiquitin ligases with VIPER-TACs. http://dlvr.it/TJLmvh
🚨Hiring Alert🚨 Recruiting an accomplished leader to serve as Director and Head of Discovery #Proteomics at Amgen. Find out more and apply here: careers.amgen.com/en/job/south...
Director of Discovery Proteomics Jobs at Amgen in United States of America
Explore the details of a Director of Discovery Proteomics career in South San Francisco. Live. Win. Thrive. Search and apply for a rewarding new career at Amgen.
careers.amgen.com
New @biorxivpreprint.bsky.social preprint from Amgen induced proximity group and @dannomura.bsky.social lab just posted that describes Covalent Destabilizing Degrader of AR and AR-V7 in Androgen-Independent Prostate Cancer Cells. Read on for an overview 1/7 www.biorxiv.org/content/10.1...
Covalent Destabilizing Degrader of AR and AR-V7 in Androgen-Independent Prostate Cancer Cells
Androgen-independent prostate cancers, correlated with heightened aggressiveness and poor prognosis, are caused by mutations or deletions in the androgen receptor (AR) or expression of truncated varia...
biorxiv.org
Happy to share a @nature.com News and Views on the amazing discoveries by @brianliau.bsky.social & Ning Zheng labs on how a molecular glue unexpectedly mimics the effect of cancer mutations. Such cool science and with implications to drug discovery. Check it out. www.nature.com/articles/d41...
Molecular glue unexpectedly mimics the effect of cancer mutations
Protein structures could guide the design of molecular glue degraders.
nature.com
Our latest BioRxiv by @cmzammit.bsky.social, Cory Nadel, @pottslab.bsky.social on a covalent destabilizing degrader against AR & AR-V7 in prostate cancer that targets an IDR C125 to destabilize, inhibit, and degrade TF! Thanks to @amgen.bsky.social, MTI, Berkeley MCB/Chemistry, NCI, TMFCR, and NSF!
Covalent Destabilizing Degrader of AR and AR-V7 in Androgen-Independent Prostate Cancer Cells
Androgen-independent prostate cancers, correlated with heightened aggressiveness and poor prognosis, are caused by mutations or deletions in the androgen receptor (AR) or expression of truncated varia...
biorxiv.org
It’s been a tough few weeks. My 10yo daughter was diagnosed with a very rare, aggressive cancer called interdigitating dendritic cell sarcoma (IDCS). I’m reaching out to identify clinicians/patients who have encountered pediatric IDCS or other (non-LCH) dendritic or histiocytic sarcomas cases.
Harvard and Google AI mapped one cubic millimeter of a human brain. It took up 1.4 petabytes of storage just in pictures of the specimen. So the entire brain would take ~ 1.6 zettabytes of storage, cost $50 billion, and require 140 acres. It would be the largest data center on the planet— one brain.
Full scan of 1 cubic millimeter of brain tissue took 1.4 petabytes of data, equivalent to 14,000 4K movies — Google's AI experts assist researchers
Mind-boggling mind research.
tomshardware.com
Somatic FBXW7-R465C mutant shows promise in targeted protein degradation in cancer cells. This approach enhances protein degradation specificity in diseased cells. Congrats Xiaoyu Zhang and colleagues. 🧪 #chembio #TPD #CancerResearch www.biorxiv.org/content/10.1...
Harnessing the FBXW7 somatic mutant R465C for targeted protein degradation
Targeted protein degradation (TPD) is a pharmacological strategy that eliminates specific proteins from cells by harnessing cellular proteolytic degradation machinery. In proteasome-dependent TPD, exp...
biorxiv.org
Scientists, academics, researchers: We’re excited to share that @altmetric.com is now tracking mentions of your research on Bluesky! 🧪
Altmetric@altmetric.com · 2y agoThere are already many articles for which there is more attention on Bluesky than on other comparable micro-blogging sites, meaning the academic community and the general public have clearly adopted Bluesky as one of its core places to disseminate and discuss new research. A Place of Joy.
Got the chance to put together the "Click of Chemical Biologists" starter pack v1 and v2 over the Thanksgiving Break. Feel free to ping me on who else I might be missing! V1: go.bsky.app/3P5i7nJ V2: go.bsky.app/Cr4ej7
We designed MS2 and PP7 binding coat proteins that are degraded in cells except when bound by their hairpin RNAs. You can check out our pre-print here: tinyurl.com/27p7hyt9, and listen to a Google AI-generated podcast on it here: notebooklm.google.com/notebook/d71...
A fun journey of full-length EGFR with Dan Leahy and @edwardmarcotte.bsky.social at UT Austin @utaustin.bsky.social. See below: Structure and organization of full-length Epidermal Growth Factor Receptor in extracellular vesicles by cryo-electron tomography www.biorxiv.org/content/10.1...
Came to a new understanding of 'colocalization' since starting STED microcopy: there is no colocalizaiton, objects cannot occupy the same physical space!
If you are not yet sure how to best spend your time in May next year, come to Chicago & hear about small molecule drug discovery. It‘s where all the cool stuff is currently happening (I may be slightly biased in my opinion). www.medchemfrontiers.org/@acsmedi.bsk...
