Ingo Hartung
@hartungingo.bsky.social
discovery chemistry nerd @Merckgroup; oncology, immunology, targeted protein degradation, ADCs; soccer, politics, tapas can slip into the feed; my own views
📢We are delighted to share our latest themed collection on Induced-Proximity Pharmacology, guest edited by @lynjoneschembio.bsky.social, @hartungingo.bsky.social & Lindsey James! Explore the articles that make up this fantastic collection, here👇 pubs.rsc.org/en/journals/... #chemsky 🧪
Great visit to our longstanding collaboration partners at the ICR discussing how small molecules continue to generate clinical impact. Learned a lot about how Zoran and his team tackle glue degrader discovery to deliver on the promise of expanding the druggable space.
Rossanese Lab@temt-icr.bsky.social · last yr.Great day & night discussing how to design impactful drugs 💊 with @hartungingo.bsky.social! Thanks for a great talk and lively discussion with @agako7.bsky.social, @robvanmontfort.bsky.social, Zoran Rankovich & the ICR Centre for Protein Degradation! Cheers 🍻!
Hi all, our old #sciencetwitter party place is reopening. Just in case you didn‘t get the invite… bring your Popcorn!
🚀 An inspiring milestone worth sharing! 🎥 Yesterday marked the official kick-off event for the 2nd phase of our BMBF-funded #Cluster4Future @proxidrugs.bsky.social. Thanks to all scientists, stakeholders, citizens & schools for actively participating and making it a very special day for us!
Una copa bien en alto por uno de mis autores favoritos. Gracias por las historias, las palabras, y la valentía. Buen viaje, Mario. 🥂📚 Farewell to the Last Writer of the Latin American Boom www.nytimes.com/2025/04/13/b...
Mario Vargas Llosa: An Appreciation
The Peruvian author Mario Vargas Llosa was the world’s savviest and most accomplished political novelist.
nytimes.com
Life could be worse… unfortunately, a pretty busy working week ahead.
First impressions of comparing #AACR25 coverage on Bluesky with the other place. I am used to check the conference handle regularly to build my conference schedule. Some interesting findings on Twitter, nothing here yet. I hope conference coverage will pick up here as well.
Still difficult for me to judge the reach of this platform. #AACR25 (5 weeks from now) will be the 1st real test for science posting here. The meeting program is packed w/ sessions about novel ADC approaches, degraders/proximity inducers, targeting intracktables, overcoming resistance, using AI.
Besonders die Einleitung des Artikels ist wichtig. Ich frage mich die ganze Zeit: warum sollte Putin warten, bis Europa sich besser verteidigen kann? ME ist das einzige, was ihn noch aufhält, der ukrainische Widerstand.
A bit more than one month til #AACR25 and two months til the ASCMEDI-EFMC symposium - both in Chicago. I never thought that traveling to the US may ever become an issue for political reasons. Let‘s see what the next weeks will bring…
Acyn@acyn.bsky.social · last yr.Canadian MP Charlie Angus: I am here today to urge Canadians to avoid travel to the United States if at all possible and to call on our government to stand up for our citizens who are being denied their rights through arbitrary detention in the United States.
More about rewiring transcription with bifunctional TCIP molecules: biological proof-of-concept in sarcoma cell lines www.biorxiv.org/content/10.1...
A small molecule USP7 activator from the Buhrlage Group! Important information in the SI not to be missed: significant activity differences between enantiomers & an inactive control compound. A very strong data package further enabling studies of USP7 biology.
bioRxivpreprint@biorxivpreprint.bsky.social · last yr.Small-molecule allosteric activator of ubiquitin-specific protease 7 (USP7) https://www.biorxiv.org/content/10.1101/2025.03.14.643379v1
📢Looking ahead to #AACR25 in Chicago — only 6 weeks away! Join the Meet-the-Expert session with Prof. Paul Workman, where he’ll emphasize the critical role of high-quality chemical probes in drug discovery. 📅 April 29, 2025 | ⏰ 5:00-5:45 PM Learn more👇 #CancerResearch
Summary: 1st Ph3 readout for a #PROTAC; likely path-to-approval in metastatic breast cancer patients w/ ESR1 mutations after having received endocrine therapy & CDK4/6 inhibitors; in line with previous clinical data; stock brokers don‘t understand Ph1/2 data. www.fiercebiotech.com/biotech/pfiz...
Pfizer, Arvinas post mixed breast cancer survival results in first phase 3 test for a PROTAC degrader
Pfizer and Arvinas’ estrogen receptor (ER) degrader has
fiercebiotech.com
Tja, das ist mal ein Romanbeginn, der meine Aufmerksamkeit schon im ersten Satz gewonnen hat…
Small molecular weight drug molecules are products of design. Multiple characteristics are designed into one chemical structure. Read about how the combination of experimental data with calculated properties streamlines the discovery of oral designer PROTACs: pubs.rsc.org/en/content/a... @rsc.org
Visiting #Irsee2025 was again a true pleasure. Not only the great science in a unique environment. But also the truly Bavarian weather, food & beer! Already looking forward to 25th til 27th February 2026 for #Irsee2026! @dechema.bsky.social
More biocatalysis at #Irsee2025. It took us a few years to bring Uwe Bornscheuer all the way from the baltic sea to south-western Bavaria. But it was worth the wait… reengineering methyl transferases and monooxygenases. @dechema.bsky.social
The Hit to Lead process is an integral part of contemporary drug discovery. A perspective just published in #ChemMedChem (@chemistryeurope.bsky.social), highlight the new set of @euromedchem.bsky.social best practices focused on H2L. chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/...
The European Federation for Medicinal Chemistry and Chemical Biology (EFMC) Best Practice Initiative: Hit to Lead
Best practices for the Hit-to-Lead phase of drug discovery are exemplified in this article, with links to further materials and references as a learning resource. This consensus output was produced b....
chemistry-europe.onlinelibrary.wiley.com
The new perspective from the @euromedchem.bsky.social Best Practice Initiative is now online: chemistry-europe.onlinelibrary.wiley.com/doi/abs/10.1... Best practice recommendations for the optimization from a Hit to a Lead. Kudos to Bob Young & Jean Quancard for driving this initiative!
The power & coolness of biocatalysis at #Irsee2025: Rebecca Buller from Zurich University of Applied Sciences about strategies to evolve designer enzymes. Enabling the chlorination of the complex macrolide soraphen and the derivatization of terpenes.
„Was bei diesen Wahlen passiert, wird enorme Auswirkungen auf den Rest der Welt haben.“ Timothy Snyder #Bundestagswahl2025
US-Historiker Snyder: Deutschland „wichtigste Demokratie der Welt“
Nach der Münchner Sicherheitskonferenz bleibt Ratlosigkeit: Welche Lehren sind aus den Ergebnissen der vergangenen Tage zu ziehen? US-Historiker Timothy Snyder findet kritische Worte für Trump – und r...
rnd.de
It's finally out – actually out and in print! Many thanks to @jcornlab.bsky.social @matthiasmuhar.bsky.social @jakobfarnung.bsky.social and all the fantastic collaborators. What started as pure curiosity lead to an amazing find! www.nature.com/articles/s41...
C-terminal amides mark proteins for degradation via SCF–FBXO31 - Nature
SCF–FBXO31 scans proteins for C-terminal amidation and marks them for subsequent proteasomal degradation.
nature.com
Talking about VHL-based #PROTACs: Check out our newest publication from the @proxidrugs.bsky.social consortium in which we propose & exemplify a generalizable workflow for the validation of E3 ligands for developing PROTACs. pubs.acs.org/doi/10.1021/...
Ingo Hartung@hartungingo.bsky.social · 2y agoThere are many reasons for drug discovery scientists to be interested in #PROTACs. VHL-based PROTACs should not be ignored, there are important use cases for them. @alessiociulli.bsky.social & colleagues now compiled the VHL ligand chemical space in this paper: www.tandfonline.com/doi/pdf/10.1...
Still all fine on this side of the sea of greenland (formerly known as the atlantic ocean).
Jacquelyn Gill@jacquelyngill.bsky.social · 2y agoAs someone with an actual PhD in geography, I am utterly disgusted with Google for this. What a joke.
There are many reasons for drug discovery scientists to be interested in #PROTACs. VHL-based PROTACs should not be ignored, there are important use cases for them. @alessiociulli.bsky.social & colleagues now compiled the VHL ligand chemical space in this paper: www.tandfonline.com/doi/pdf/10.1...
