Join us the last time before the summer break! Cesar A. Ramirez-Sarmiento will talk about "Unveiling the fold-switching behavior of RfaH: echoes of the past, signals of the present". As always, Tue 5PM CET, follow the link to sign-up: tinyurl.com/prose-seminar2

Join ProSe next week Tuesday, when Noelia Ferruz @noeliaferruz.bsky.social is talking about "Controllable Protein Design with Protein Language Models and Reinforcment Learning", TUE, May 12, 5PM CET! Sign-up here: tinyurl.com/prose-seminar2

Come listen to my talk about how enhancers evolve and how promoters emerge from randomly synthesized DNA sequences!

Protein Structure Evolution (ProSE) Seminar@proteinstructure.bsky.social · 4mo ago

Our next speaker will be Timothy Fuqua @timothyfuqua.bsky.social with "The Evolution and Emergence of Regulatory DNA", 14th April, 5PM CET. Sign-up here: tinyurl.com/prose-seminar2

Our next speaker will be Timothy Fuqua @timothyfuqua.bsky.social with "The Evolution and Emergence of Regulatory DNA", 14th April, 5PM CET. Sign-up here: tinyurl.com/prose-seminar2

Our next Talk will be "Protein Origami and the Hidden Rules of Functional Innovations"! March 11th, 5PM CET. Sign-up here: tinyurl.com/prose-seminar2

ProSe goes into the 2nd with a talk by Vyacheslav Tretyachenko on the pervasive alternative translation in the human proteome. Join us tomorrow via Zoom, 4PM GMT, 5PM CET.

Protein Structure Evolution (ProSE) Seminar@proteinstructure.bsky.social · 6mo ago

Next up in our ProSE seminar series: Vyacheslav Tretyachenko on alternative translation in the human proteome Register to join: tinyurl.com/prose-seminar2 Past seminars: tinyurl.com/ProSE-videos

Next up in our ProSE seminar series: Vyacheslav Tretyachenko on alternative translation in the human proteome Register to join: tinyurl.com/prose-seminar2 Past seminars: tinyurl.com/ProSE-videos

Check out our new review in Nature Reviews Genetics on de novo emerged genes and proteins. How they emerge, are lost and persist - and how de novo emerged proteins relate to randomized proteins! @bornberglab.bsky.social www.nature.com/articles/s41...

Emergence and evolution of protein-coding de novo genes - Nature Reviews Genetics

De novo gene evolution entails the birth of new genes from previously non-coding DNA. In this Review, Bornberg-Bauer and Eicholt overview how protein-coding de novo genes are identified, the mechanist...

nature.com

Bornberglab@bornberglab.bsky.social · 6mo ago

New review out in Nat Rev Genet: Emergence & evolution of protein-coding de novo genes by Erich and Lars Eicholt @lacholt.bsky.social. How non-coding DNA becomes translated, persists or is lost in populations, and can yield structured/functional proteins—plus methods & open questions! rdcu.be/e09SM

New review out in Nat Rev Genet: Emergence & evolution of protein-coding de novo genes by Erich and Lars Eicholt @lacholt.bsky.social. How non-coding DNA becomes translated, persists or is lost in populations, and can yield structured/functional proteins—plus methods & open questions! rdcu.be/e09SM

Emergence and evolution of protein-coding de novo genes

Nature Reviews Genetics - De novo gene evolution entails the birth of new genes from previously non-coding DNA. In this Review, Bornberg-Bauer and Eicholt overview how protein-coding de novo genes...

rdcu.be

🚀We’re excited to share our new paper in Bioinformatics! We introduce a user-friendly toolkit that implements our novel DeNoFo file-format for standardised annotation of de novo gene detection workflows — enabling reproducible methodology descriptions and easier dataset comparison across studies.

Join us tomorrow! Joana Pereira is talking about AI-powered classification and discovery across the protein universe. @joanampereira.bsky.social 5PM CET, link in the post and in our bio.

Protein Structure Evolution (ProSE) Seminar@proteinstructure.bsky.social · 9mo ago

The next ProSE Seminar will be given by Joana Pereira @joanampereira.bsky.social (VIB, KU Leuven) 🗓️ November 11th, 5pm CET Registration is now open: tinyurl.com/prose-seminar2 Please share!

The DeNoFo format & toolkit for annotating, assessing and comparing the tools and tresholds used in studies of de novo evolved genes is out now in Bioinformatics! Great effort led by @drdomain.bsky.social and Anna Grandchamp! academic.oup.com/bioinformati...

DeNoFo: a file format and toolkit for standardized, comparable de novo gene annotation

AbstractMotivation. De novo genes emerge from previously non-coding regions of the genome, challenging the traditional view that new genes primarily arise

academic.oup.com

Elias Dohmen@drdomain.bsky.social · last yr.

De novo genes research community 🧬 - please consider using for your future or past work our new methodology annotation format for better comparability of studies and higher reproducibility. (1/3)

The next ProSE Seminar will be given by Joana Pereira @joanampereira.bsky.social (VIB, KU Leuven) 🗓️ November 11th, 5pm CET Registration is now open: tinyurl.com/prose-seminar2 Please share!

Protein Structure Evolution (ProSe) Seminar is now on BlueSky! Every 2nd Tuesday, 4PM GMT. Sign-Up: tinyurl.com/prose-seminar2 Organized by Claudia Alvarez Carreño, Zachary Ardern, Lars Eicholt, Carolina Sanchez-Rocha, Sergio Romero Romero and Md. Hassan Uz-Zaman.

The next Protein Structure Evolution Seminar will be given by Stephen Fried (JHU): Title: “Who Cares About Protein Refolding Anyway?: Why Some Microbes Do and Others Don’t” Date: October 14th, 5 pm CET Registration link: tinyurl.com/prose-seminar2