www.nature.com/articles/s41... This was an impressively massive sample size used to identify an ultra-rare (0.01%) coding variant in #FNIP1. The ‘skinny gene’ mutation provides protection against a range of metabolic-driven diseases.
FNIP1 variants are associated with favourable metabolism in 1 million humans - Nature
The FNIP1 pathway has a role in human energy metabolism, and its inhibition is a potential therapeutic strategy in cardiometabolic disease.
nature.com