Excited to share matchbox. It’s super fast and versatile to search for patterns in reads, I’m curious to see all the uses it will find! Congrats to @jakobschuster.bsky.social , co-supervisors @michaelbclark.bsky.social @mritchieau.bsky.social and team! www.biorxiv.org/content/10.1...

Powerful read processing with matchbox https://www.biorxiv.org/content/10.1101/2025.11.09.685711v1

Holy crap! This looks awesome. We've been working toward something just like this (github.com/COMBINE-lab/...), and matchbox seems great; and in Rust! Perhaps we've been scooped, but this looks amazing either way!

GitHub - COMBINE-lab/seqproc

Contribute to COMBINE-lab/seqproc development by creating an account on GitHub.

github.com

bioRxiv Bioinfo@biorxiv-bioinfo.bsky.social · 9mo ago

Powerful read processing with matchbox https://www.biorxiv.org/content/10.1101/2025.11.09.685711v1

Keen to use an open source workflow for nanobody discovery? Check out Alpseq 🦙 Alpseq’s diversity analysis, enrichment counts & clustering allow different approaches for nanobody selection Great collab with bioinformaticians @qgouil.bsky.social Kathleen Zeglinski www.biorxiv.org/content/10.1...

alpseq: an open-source workflow to turbocharge nanobody discovery with high-throughput sequencing

Nanobodies have emerged as promising tools for many biotechnological applications due to their small size, high stability, and remarkable binding specificity. Next-Generation Sequencing (NGS) enables ...

biorxiv.org

Excited to share our new preprint: alpseq - an open-source workflow to turbocharge nanobody discovery! 🦙 doi.org/10.1101/2025... This work is the result of Kathleen Zeglinski’s brilliant PhD work and an outstanding collaboration with Wai-Hong Tham's group! Find alpseq at github.com/kzeglinski/a...

alpseq: an open-source workflow to turbocharge nanobody discovery with high-throughput sequencing

Nanobodies have emerged as promising tools for many biotechnological applications due to their small size, high stability, and remarkable binding specificity. Next-Generation Sequencing (NGS) enables ...

doi.org

🚴‍♂️ I’m riding to make a difference: help me support cancer research 🎗️ I’m training for a ride and raising funds for cancer research, support and prevention. You can contribute via my fundraising page here: 👉 vicdiscovery.tourdecure.com.au/quentin-gouil Thank you for your support!

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Long-read transcriptomics is advancing quickly, we benchmarked leading bulk and single-cell protocols in this awesome collaborative effort! We hope it will be a valuable resource for the community. Congrats @youyupei.bsky.social @mritchieau.bsky.social @michaelbclark.bsky.social and all!

Yupei You@youyupei.bsky.social · 11mo ago

Excited to share our latest preprint: LongBench—a cross-platform reference dataset profiling cancer cell lines with bulk and single-cell approaches. www.biorxiv.org/content/10.1...

>1,000 long-read tools in the latest update! 🚀 Long-read trancriptomics heating up 🔥 long-read-tools.org

Discovery: mRNA vaccine candidate blocks malaria from reproducing inside mosquitoes, cuts transmission by up to 99.7%. Built on cryo-EM insights into parasite’s fertilisation machinery. A key step towards elimination. In @science.org 🔗 www.wehi.edu.au/news/reveale...

Cryo-EM of fertilisation complex Pfs230-Pfs48/45 from malaria parasites! 💕💗 🦟 Transgenic parasites without Pfs230 D13D14 do not transmit 🦙 💉Nanobodies + mRNA induced antibodies reduce transmission New in @Science.org www.science.org/doi/10.1126/... #ScienceResearch #Malaria #WEHI

🚨 We're hiring! 🚨 The School of Mathematics & Statistics, UniMelb seeks a scientist in Machine Learning in Omics to lead research in statistical methods for omics. 📍 MIG | 📅 By Apr 11 🔗 jobs.unimelb.edu.au/en/job/91945... #MachineLearning #Omics #DataScience #HigherEd #Mathematics #Statistics

Interested in #malaria transmission and fertilisation? Check out our new work using cryo-EM of ENDOGENOUS sexual stage parasites to determine the Pfs230-Pfs48/45 fertilisation complex - please read & share! structures| nanobodies |human immune responses | mRNA-LNP www.biorxiv.org/content/10.1...

Do you love software engineering for exciting biological applications, open science,open source, R, Bioconductor, modern web, cloud& ML technologies? We're looking for a software engineer to work on R/Bioconductor tools for biological data science and AI embl.wd103.myworkdayjobs.com/en-US/EMBL/j...

Our new paper examining how to analyse longread RNA-seq with no reference genome. We compare approaches for assembly and downstream analysis, from transcript accuracy to differential expression. Lead by @alexyfyf.bsky.social. Thnx to all contributors incl. @qgouil.bsky.social for the pea data!

bioRxivpreprint@biorxivpreprint.bsky.social · last yr.

Towards accurate, reference-free differential expression: A comprehensive evaluation of long-read de novo transcriptome assembly https://www.biorxiv.org/content/10.1101/2025.02.02.635999v1

This blew my mind youtu.be/Xe-83tBcxhs The double Holliday junction comes to life! Gorgeous work from @drewberry.bsky.social and team.

DNA Break Repair by Homologous Recombination (2024) Drew Berry wehi.tv

YouTube video by WEHImovies

youtu.be

No genome, no problem! Check out @nadia-davidson.bsky.social and Alex Yan’s benchmark of reference-free Diff Expr. Helping us out with our 🌱 transcriptomes! www.biorxiv.org/content/10.1...

Towards accurate, reference-free differential expression: A comprehensive evaluation of long-read de novo transcriptome assembly

Long-read RNA sequencing has significantly advanced transcriptomics by enabling the full length of transcripts to be assessed. However, current analysis methods often depend on a high-quality referenc...

biorxiv.org