@ramsdenlab.bsky.social
Sosumu Tonegawa, Discovered V(D)J recombination. news.mit.edu/2026/mit-pro...
MIT Professor Susumu Tonegawa, renowned molecular biologist and Nobel laureate, dies at 86
Susumu Tonegawa, a renowned MIT professor of biology and neuroscience and a Nobel laureate, has died at the age of 86. His discovery of how the immune system generates many different antibodies earned...
news.mit.edu
Happy to share that I will be joining the Biology Department and Holden Comprehensive Cancer Center at University of Iowa as an assistant professor in summer 2027! My lab will study how recombination is regulated to prevent non-allelic repair and genome rearrangements, and their relation to cancer.
Carolyn started this as a whole-genome revisit of the classic 1996 papers on spontaneous nondisjunction from Hawley (Dros X) and Sherman (human 21) labs. She looked at a metacentric (Dros 2) and found that the rules are different - no obvious relationship between ndj and crossovers. Shape matters!
Genetics Society of America@genetics-gsa.bsky.social · 2mo agoCarolyn Turcotte and @jeffsekelsky.bsky.social employed whole-genome sequencing to study spontaneous meiotic nondisjunction of the metacentric chromosome 2 in #Drosophila, identifying chromosome-specific mechanisms of meiotic nondisjunction. 🪰 Learn more in #GENETICS: 🔗 buff.ly/LmC3qZU
Happy to share our collaborative project with Stephane Marcand, on the protective role of Rap1 at telomeres. It turned out that our favorite protein, MRX, has the ability to measure telomere length, and activate response pathways when telomeres become too short. www.nature.com/articles/s41...
Interesting paper from Virginie Ropars and collegues about the architecture of WRN and KU interaction. Interestingly, WRN binds on the internal (end-distal) side of KU. Thanks for this interesting collaboration! @pietropichierri.bsky.social www.nature.com/articles/s41...
Structural basis of Ku-mediated activation of WRN exonuclease activity - Nature Communications
The WRN helicase helps to protect stalled DNA replication forks during replication stress, but its activation mechanism remains unclear. Here, the authors demonstrate that Ku binds and stimulates WRN ...
nature.com
Big congrats to Spencer Thompson on defending his thesis today! Beautiful @lumicks.bsky.social C-Trap single-molecule work and a major MD/PhD milestone. Proud PI! BioRxiv coming soon.
Come work with us! Please share with anyone who might be a good fit!
Chowdhury Lab@chowdhurylab.bsky.social · 4mo agoThe Chowdhury Lab at the Dana-Farber Cancer Institute is hiring a Senior Research Technician! If you are passionate about NGS and its applications in cancer research, apply here: careers.dana-farber.org/job/650/seni...
Our lab at the UC Irvine is currently hiring a postdoctoral researcher. We have a thriving and growing biomedical research campus and are looking for candidates with a strong interest in DNA damage and repair, cancer etiology, and cancer health disparities. Apply at recruit.ap.uci.edu/JPF09440
As a child, @phosphotig.bsky.social dreamed of being an astronaut, but her curiosity led her to scientific research. Now, she leads her own lab at UNC-Chapel Hill, & studies oxidative stress to find better therapies for triple-negative breast cancer. #WomensHistoryMonth www.asbmb.org/asbmb-today/...
Learning, leading and lifting others
Tigist Tamir’s journey from aspiring astronaut in Ethiopia to cancer researcher at the University of North Carolina highlights the power of mentorship, persistence and curiosity in shaping a scientifi...
asbmb.org
Pleased to share our paper. We found surprising widespread glycogen accumulation in A-T due to mitochondrial impairment that can be improved by targeting the unexpected FNIP2-SERCA2b-axis. #AtaxiaTelangiectasia #ATM #RareDisease #Metabolism #Mitochondria www.nature.com/articles/s41...
Targeting the FNIP2-SERCA2b axis improves metabolic and mitochondrial defects in Ataxia Telangiectasia - Cell Death & Disease
Cell Death & Disease - Targeting the FNIP2-SERCA2b axis improves metabolic and mitochondrial defects in Ataxia Telangiectasia
nature.com
The Sfeir Lab at MSKCC is hiring a Research Assistant! We are looking for a motivated scientist with at least 2 years of research experience and a two-year commitment. Learn more about our work here www.sfeirlab.com, and message me your CV and cover letter if interested
Sfeir Lab
The official website of the Sfeir Lab at the Skirball Institute of Biomolecular Medicine of New York University Langone Medical Center.
sfeirlab.com
Just in time for my grad school lecture on NER!
Luijsterburglab@luijsterburglab.bsky.social · 6mo agoOur great collaboration with the lab of Wei Yang and Kaoru Sugasawa is now online in Nature. We’re glad we could contribute some cell biology to complement this beautiful structural and biochemical work. www.nature.com/articles/s41...
Great conference!!
Bret Freudenthal@freudlab.bsky.social · 6mo ago📣 The 2026 Midwest DNA Repair Symposium is coming to Kansas City (registration is open) 🗓 May 30–31, 2026 ✨ Talks will be selected from abstracts, with a strong focus on trainees and new investigators. Please RT & share with your labs! 🔗 sites.google.com/view/kumc-mi...
RNAseH2 is super picky...which is not always a good thing?
Bret Freudenthal@freudlab.bsky.social · 6mo ago🎉Kicking off 2026 with our first paper from the Freudenthal lab in NAR. Ribonucleotides reshape telomeric G4s and are resistant to RNase H2 repair. Congrats to the authors and huge thanks to our collaborator Hui-Ting Lee! academic.oup.com/nar/article/...
Very cool!
Luijsterburglab@luijsterburglab.bsky.social · 7mo agoExcited to share our new Nature study! 🧬 We (sidrituruci.bsky.social et al) discovered that CFAP20 helps clear stalled RNAPII, preventing harmful clashes with DNA replication machinery. This protects cells from R-loops and genome instability. Full paper: www.nature.com/articles/s41...
Repair of DNA double-strand breaks after low radiation doses in childhood cancer survivors and matched cancer-free individuals https://www.biorxiv.org/content/10.64898/2025.12.22.695953v1
Is NHEJ truly a double-strand break repair pathway...repairing both strands, at the same time?
Great piece of work - congratulations, all!
Alberto Marin@albertomarin.bsky.social · 8mo agoThrilled to share that my postdoc research is published today in @science.org! We found that DNA repair uses cohesin complexes to build new chromatin loops that guide the homology search and boost accurate repair! 1/n www.science.org/doi/10.1126/...
Very cool! Figs 2 and 3 are especially cool!
Pia Reichl@pia-rei.bsky.social · 8mo agoMy PhD work is out as a preprint! Have a read 😊👇🏻
So cool. And hey, its a good thing NHEJ doesnt slow down when you get sleepy.
Pablo Huertas’ lab@pablohuertaslab.bsky.social · 8mo agoFinally published! Our work on how the #CircadianClock controls DNA repair. This has direct implications for cancer treatment: #Chronotherapy. @CABIMER @UniSevilla rdcu.be/eSwxl
New study from the lab on genetic relationship between 53BP1-RIF1 and DNA-PKcs on DSB repair outcomes. Led by PhD student @kaelamakins.bsky.social www.nature.com/articles/s41...
53BP1-RIF1 and DNA-PKcs show distinct genetic interactions with diverse chromosomal break repair outcomes - Nature Communications
DNA double strand breaks can be repaired by several pathways leading to different genetic outcomes. Here, the authors define the interplay between the DNA damage response factors 53BP1-RIF1 and core n...
nature.com
🎉 Joint paper from the Freudenthal and @tmweaver.bsky.social Labs! Abbey Vito’s first publication discusses a tug-of-war between BER enzymes and chromatin for access to damaged DNA, a battle central to genome stability. Built on Tyler's foundational work! tinyurl.com/ywkt2bt5
Base excision repair in chromatin: A tug-of-war for DNA damage
Base excision repair (BER) is a genome surveillance pathway responsible for repairing DNA base lesions distributed throughout the chromatinized eukary…
tinyurl.com
H2B ubiquitination by RNF20/40 safeguards replication fork dynamics in human cells, by facilitating fork reversal and recruiting RNF169 that protects from excessive degradation of nascent DNA @penengolab.bsky.social and collaborators www.embopress.org/doi/full/10....
R.I.P Hamilton Smith, 1978 Nobel Laureate for the discovery of type II restriction-modification systems (HindII).
Pol delta's exo at it again!
Petr Cejka@cejkalab.bsky.social · 9mo agoSee our paper “Mechanism of trinucleotide repeat expansion by MutSβ-MutLγ and contraction by FAN1”. Using biochemistry, we show how DNA incisions by the MutLγ nuclease can lead to expansions, and how expansion is prevented by FAN1. Well done Issam and Valentina! www.nature.com/articles/s41...
See our paper “Mechanism of trinucleotide repeat expansion by MutSβ-MutLγ and contraction by FAN1”. Using biochemistry, we show how DNA incisions by the MutLγ nuclease can lead to expansions, and how expansion is prevented by FAN1. Well done Issam and Valentina! www.nature.com/articles/s41...