I am delighted to announce that The Department of Human Genetics at the University of Utah is continuing a multi-year recruiting initiative for multiple tenure-track faculty positions at the rank of Assistant Professor. Please share and consider applying! utah.peopleadmin.com/postings/208...

We are recruiting new faculty at all levels who seek to solve fundamental problems in biology and disease. @cri-utsw.bsky.social is an exceptional and highly collaborative environment to build a research program and pursue ambitious science. Join us!

Children's Research Institute at UT Southwestern@cri-utsw.bsky.social · 3w ago

Come be part of our #relentlessdiscovery and discover the treatments of tomorrow. Faculty recruitment through Oct. 15 👉 cri.utsw.edu/careers @seanjmorrison.bsky.social @rjdlab.bsky.social @haozhulab.bsky.social @hrshin.bsky.social @peterlylab.bsky.social @henrydebelly.bsky.social

NEW PAPER: Human PIF1 clears secondary DNA structures by coupled DNA unwinding and rewinding activities — with contributions from Jessica Hudson and Ulrich Rass at the GDSC. genesdev.cshlp.org/content/earl...

For the past 30 years, “whole-genome sequencing” has been a misnomer. Today the T2T Consortium publishes a dozen papers heralding a future of truly complete genomes for humans and nearly any vertebrate 👨‍🔬🐒🐦🐀🦒🐎🫏🐹🐟 (sorry, no salamanders): www.cell.com/consortium/t... 🧵[1/15]

1 in 280 people have Lynch syndrome; about 1 million in the US alone. It's a heritable condition where the DNA proofreading machinery fails, leading to VERY high rates of certain cancers (colorectal & endometrial). A new vaccine could intercept tumors in these patients, saving lives.

Testing is underway on vaccines to intercept brewing colon cancer before it takes root

Scientists are creating a new kind of vaccine that teaches the immune system to intercept a type of brewing colon cancer before it turns into a full-fledged tumor.

apnews.com

We (Department of Cell Biology & Human Anatomy) at UC Davis Med School are hiring an assist/assoc professor. Search is underway: recruit.ucdavis.edu/JPF07708

Assistant/Associate Professor- Cell Biology & Human Anatomy

University of California, Davis is hiring. Apply now!

recruit.ucdavis.edu

Come be our colleague. I have been in this Division for 27 years (4 as a postdoc and 23 as a PI). It is an amazing place to work, collaborate, and be inspired. If you are applying to be an Assistant or Associate Professor this Fall, don't miss this deadline.

Fred Hutch Basic Sciences Division@basicsci.fredhutch.org · last mo.

Join @FredHutch.org's Basic Sciences Division as an Assistant or Associate Professor and help shape the future of fundamental biology. We welcome applicants whose work will complement, extend, or bring new directions to the division.

Fantastic talks at the FASEB Genetic Recombination and Genome Rearrangements this year. Pictured here with Wolf Heyer, my postdoc mentor, and Aurèle Piazza. Very lucky to be part of this community.

Check out our published work: We show that L1 insertion intermediates can recombine with one another or with DNA breaks to form genome rearrangements, highlighting the risk of L1 retrotransposition causing genomic instability. @kathleenhburns.bsky.social www.nature.com/articles/s41...

Why is the X chromosome rich in L1 mobile elements? @science.org X-chromosome inactivation draws L1 mutagenesis to the human X chromosome | Science www.science.org/doi/10.1126/...

X-chromosome inactivation draws L1 mutagenesis to the human X chromosome

X-chromosome inactivation (XCI) enables gene dosage compensation in XX eutherians. Long interspersed element-1 (LINE-1 or L1) retrotransposons are unusually abundant on the human X chromosome and are ...

science.org

Planning to apply for faculty positions this fall? Join the GSA Education Committee on July 22 for the New faculty workshop: "How to get a job and thrive in it!" Learn about applications, interviews, negotiations, and succeeding in your first year. 🔗Register now: buff.ly/WVy6b6T

DNA mismatch repair (MMR) deficiency is an important driver of cancer genome instability. Yet it is usually treated as a binary label 0️⃣/1️⃣: MSI-high or not. Our new preprint -- fresh from the oven🔥 -- argues that this simple dichotomy obscures the underlying biology.

Do you work in #cancer and feel behind-the-curve in #CRISPR state of the art? Get up to speed fast with this review! Huge kudos to Joshua Casan, Samuel Grigg, and Carolyn Shembrey for heavy lifting to pull this together. www.nature.com/articles/s41...

CRISPR in clinical oncology: translational advances from molecular diagnostics to therapeutics - Nature Reviews Clinical Oncology

CRISPR–Cas technologies provide a modular, programmable platform for sequence-specific targeting of DNA or RNA and have advanced from experimental molecular biology tools to clinical translation. This...

nature.com

I am thrilled to share that UC Berkeley and UCSF have launched a joint initiative in Computational Biomedicine! cdss.berkeley.edu/news/uc-berk... We will soon be recruiting new faculty and postdoctoral fellows. Please repost to help spread the word.

UC Berkeley and UCSF Launch Computational Biomedicine Initiative

UC Berkeley and UCSF have launched a joint program called the Bakar Computational Biomedicine Initiative to develop the frontier of AI and biomedicine, tremendously accelerating advances in clinical c...

cdss.berkeley.edu

Replication fork directionality reveals how structural variants arise under replication stress https://www.biorxiv.org/content/10.64898/2026.06.29.735381v1

Replication protein A prevents unregulated priming and Rad51 loading on single-stranded DNA in nuclear extracts of Xenopus eggs https://www.biorxiv.org/content/10.64898/2026.06.09.731035v1

We invite applications for a tenure-track assistant professor position in evolutionary ecology, beginning in the academic year 2027. Review of applicants will begin on November 1, 2026 & will continue until the position is filled. For more details and to apply, visit: jobs.uiowa.edu/faculty/view...

🧬 ⛓️‍💥 Our paper is now out in @natsmb.nature.com ! We examined the fate of replication forks that collapse at single-strand DNA breaks (SSBs) in vertebrates 🐸, comparing the consequences of collapse at single vs convergent forks. www.nature.com/articles/s41...

Distinct repair outcomes from single and convergent replication fork collapse - Nature Structural & Molecular Biology

Here the authors show that collapse of single replication forks causes recombination, end fusions or degradation but does not restart DNA synthesis. In contrast, collapse of convergent forks completes...

nature.com

Happy to share that I will be joining the Biology Department and Holden Comprehensive Cancer Center at University of Iowa as an assistant professor in summer 2027! My lab will study how recombination is regulated to prevent non-allelic repair and genome rearrangements, and their relation to cancer.

Excited to finally share our preprint on mapping the genetic interaction network of the DNA damage response with combinatorial knockout screens led by Sam Hayward, Alina Vaitsiankova, and Tomas Lama-Diaz! www.biorxiv.org/cgi/content/...

Mapping the genetic landscape of the DNA damage response with Cas12a-based combinatorial knockout screens

The DNA damage response (DDR) is a complex network of cellular pathways that ensures the faithful maintenance of our genomes upon a wide array of genomic insults. To elucidate the functional architect...

biorxiv.org

The reason I’m coming back is because in July, I will start as a Ramón y Cajal investigator at the Instituto de Parasitología y Biomedicina López-Neyra, in the beautiful town of Granada. I am so excited about this.

At IPBLN, my lab will study how bacteria mutate, repair their DNA, and evolve antibiotic resistance. Again, thank you so much to everyone who made this possible.

NOFO for the K32 postdoc award is published. NCI, NIDCR, NIAID, NINDS, NIBIB are signed on. files.simpler.grants.gov/opportunitie...

Are you ready for the Summer? Social DNAing is! Check out the 2026 Summer line-up! Please note one schedule change on June 4th, 2026. Please RT! Sign up at cancer.columbia.edu/research/pro...

Can SMC5/6 status help guide precision cancer therapy? A new NAR Cancer study links deleterious SMC5/6 variants to tumor mutational burden and immunotherapy responses, driven via POLE dysfunction and mismatch repair deficiency.https://academic.oup.com/narcancer/article/8/2/zcag012/8688771

Disruption of the structural maintenance of chromosomes 5/6 complex enables tumor mutagenesis

Abstract. The structural maintenance of chromosomes (SMC) 5/6 complex is conserved and essential for mammalian development. SMC5/6 germline variants in cel

academic.oup.com

Pan-Cancer Genomic Scars of Alternative End Joining and Single-Strand Annealing https://www.biorxiv.org/content/10.64898/2026.05.22.727283v1

Amazing job opportunity at Brandeis - we are looking for a new manager of our Light Microscopy Facility! Cool instruments, a great community to work with, lots of opportunities for growth - please circulate! brandeis.wd5.myworkdayjobs.com/en-US/Jobs/j...

Light Microscopy Facility Manager

The main purpose of this job is to bring cutting-edge light microscopy research approaches to Brandeis researchers and oversee the day-to-day operations of the Brandeis light microscopy facility. The ...

brandeis.wd5.myworkdayjobs.com

How do cancer-associated eccDNAs arise? Our work shows that single-strand DNA damage in repetitive sequences can trigger i-loop formation and eccDNA generation. What started at telomeres may reflect a much broader principle across the genome and help explain how ecDNA may emerge in cancer. 1/2

Topographical archetypes of somatic mutagenesis in cancer https://www.biorxiv.org/content/10.64898/2026.04.18.719374v1

Happy to see the poster from two fantastic undergraduate students working with me, Jasmine Jia and Lulu Schloss, at the @ucdavis.bsky.social Undergraduate Research Conference, along with other students from the Heyer lab. Both are graduating this year and continuing on to graduate school!