A study using electroencephalogram (EEG) recordings shows that brain activity under anesthesia shares features with both coma and sleep states, albeit in different areas of the brain and at different EEG frequencies. In PNAS: https://ow.ly/hIri50Z1cZO

New paper in @pnas.org #Neuroskyence The brain state during general anesthesia looks like hybrid of sleep and coma. We also identify distinct neural patterns that are unique to anesthesia using #EEG 👇 www.pnas.org/doi/10.1073/... @yale.edu @wutsaiyale.bsky.social @yaleschoolofmed.bsky.social

Anatomy sets things up, but it’s not the whole story. A low-D communication subspace from PFC to motor cortex reconfigures with context, routing action signals so the same movements can be driven by different rules without rewiring the whole network. www.nature.com/articles/s41... #neuroscience

A communication subspace relays context-dependent actions from human prefrontal to motor cortex - Nature Neuroscience

Context-dependent behavior selects actions according to task demands. Using direct brain recordings in humans, Binish et al. uncover how coordinated population activity efficiently channels informatio...

nature.com

Very excited to share our latest paper led by @nbinish.bsky.social in @natneuro.nature.com We demonstrate how a communication subspace channels higher-dimensional PFC dynamics into lower-D motor activity to enable efficient behavior using human iEEG. www.nature.com/articles/s41... #neuroskyence

A communication subspace relays context-dependent actions from human prefrontal to motor cortex - Nature Neuroscience

Context-dependent behavior selects actions according to task demands. Using direct brain recordings in humans, Binish et al. uncover how coordinated population activity efficiently channels informatio...

nature.com

Two postdoc opportunities @yale.edu in human neurophysiology. One position in my lab @wutsaiyale.bsky.social focusing on human cognitive neurophysiology. Details at helfrich-lab.com/news/ Plus a possible collab with anesthesiology 👇 #NeuroTwitter #NeuroJobs #neuroskyence #EEG Please share.

Does aperiodic activity index neural excitability? Single-unit and LFP recordings during optogenetic interneuron suppression show that aperiodic activity scales with firing, but it depends on context and oscillatory power. New preprint with @juliaveit.bsky.social. www.biorxiv.org/content/10.6...

WTI's research facility, BrainWorks, has launched two social media channels to take a closer look at its welcoming environment, state-of-the-art tools, and community outreach. Follow along on: Instagram: www.instagram.com/brainworksyale Facebook: www.facebook.com/brainworksyale #KnowTogether

New paper alert 📣 #Neuroskyence "Rhythmic sampling of multiple decision alternatives in the human brain" @natcomms.nature.com together with @ycaoneuro.bsky.social @maryamtohidi.bsky.social @donnerlab.bsky.social @ktsetsos.bsky.social www.nature.com/articles/s41... 🧵1/

Rhythmic sampling of multiple decision alternatives in the human brain - Nature Communications

How humans process competing information when making multi-alternative decisions remains unclear. Here, the authors show that the brain resolves the trade-off between “evaluating within” and “comparin...

nature.com

Ripple oscillations are central for memory and sleep. But ripple detection in humans remains challenging. Here we introduce a simulation approach in @natcomms.nature.com as common ripple detectors mainly pick up 1/f noise and not genuine oscillations 👇 www.nature.com/articles/s41... #neuroskyence

Aperiodic 1/f noise drives ripple activity in humans - Nature Communications

How aperiodic 1/f noise drives ripple activity in human brain and impacts on ripple detections is not fully understood. Here authors show that ripple detections should be driven by the 1/f noise, whic...

nature.com

𝗪𝗵𝗮𝘁 𝗶𝘀 𝗻𝗼𝗶𝘀𝗲 𝗶𝗻 𝘁𝗵𝗲 𝗯𝗿𝗮𝗶𝗻? Almost always we average responses thus equating response variability with noise. Well, we shouldn't because variability is also signal, not noise to be entirely discarded. #neuroskyence doi.org/10.1016/j.ne...

Conjunctive population coding integrates sensory evidence to guide adaptive human behavior. New work led by @jonasterlau.bsky.social in @pnas.org. We used human intracranial EEG to understand how coordinated population activity supports context-dependent behavior. www.pnas.org/doi/10.1073/.... (1/4)

Understanding the mind takes many ways of seeing. Faculty at the Wu Tsai Institute are working across neuroscience, engineering, and psychology to study how the mind works. A look inside the institute’s new home shows how shared spaces and new tools are supporting discovery through collaboration.

Wu Tsai Institute: Making the right connections

With state-of-the-art research facilities and collaborative spaces, Yale's Wu Tsai Institute is on a mission to understand human cognition by bridging academic disciplines.

bit.ly

Aperiodic activity reflects pathological waveforms in epilepsy (and not necessarily hyper-excitability or altered E/I-balance). The 1/f slope goes up *or* down as function of waveforms during seizures. New work by Laura Heidiri and Frank van Schalkwijk from the lab: www.jneurosci.org/content/45/5...

Aperiodic Activity Reflects Pathologic Waveform Shapes in Focal Epilepsy

Epilepsy constitutes a clinically manifest excitability disorder that is characterized by aberrant electrophysiological activity in the electroencephalogram (EEG). The correct identification of the se...

jneurosci.org

Our new paper is out in @natneuro.nature.com How do large-scale brain networks route information about where/what to attend at fast timescales? High-frequency bursts facilitate fast communication for human spatial attention www.nature.com/articles/s41...

High-frequency bursts facilitate fast communication for human spatial attention - Nature Neuroscience

Using intracranial electroencephalography from patients with epilepsy during spatial attention tasks, this study shows that high-frequency bursts facilitate fast communications in brain networks and s...

nature.com

New work from the lab published in @cp-neuron.bsky.social by @jonasterlau.bsky.social and Jan Martini. We describe that trial-by-trial variability indexes recurrent connectivity across the cortical hierarchy, which supports reliable and flexible coding www.cell.com/neuron/abstr... (1/4)

Structure in noise: Recurrent connectivity shapes neural variability to balance perceptual and cognitive demands in the human brain

Does neural variability reflect random noise or a feature that benefits adaptive behavior? Using intracranial recordings in humans, Terlau et al. demonstrate that neural variability results from the r...

cell.com

New position, new social media account. After 5 fantastic years in Tuebingen, I moved to @yale.edu and the @wutsaiyale.bsky.social this summer - which means that I’ll be recruiting PhD students and postdocs. Please help me to spread the word and see current opportunities below 👇