rangachari lab (vijay)
@rangacharilab.bsky.social
disordered proteins, amyloids, biomolecular condensates, soft matter design. www.rangacharilab.com Chemistry and Biochemistry, School of Math and Natural Sciences Center for Molecular and Cellular Biosciences University of Southern Mississippi
I am thrilled to share our article, out in @pnas.org. Exceptional work from @malaymondal.bsky.social, who demonstrated that our redox-sensitive designer biomolecular condensates efficiently deliver a wide array of molecular cargo to HeLa cells. www.pnas.org/doi/abs/10.1...
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
pnas.org
We are excited to launch the SouthEast Amyloid CONdensate (SEACON) symposium!! Our inaugural meeting will take place in Ocean Springs, MS, in August 2025. For details, please visit: www.rangacharilab.com/1st-seacon-s...
SEACON Symposium — www.rangacharilab.com
rangacharilab.com
Excited to share our new data on the use of redox-sensitive peptide condensates as cell delivery vehicles. We show that our peptide condensates can efficiently deliver a variety of small molecules, DNA, mRNA, and proteins, to the cellular cytoplasm. www.biorxiv.org/content/10.1....
Disulfide cross-linked redox-sensitive peptide condensates are efficient cell delivery vehicles of molecular cargo.
Biomolecular condensates (BCs) are phase-separated viscoelastic hubs within demixed solutions enriched in proteins and nucleic acids. Such condensates, also called membraneless organelles, are increas...
biorxiv.org
Excited to share our latest work on amyloid-synthetic polymer blends. pubs.acs.org/doi/10.1021/...
De Novo Amyloid Peptide–Polymer Blends with Enhanced Mechanical and Biological Properties
Amyloid peptides are structurally diverse materials that exhibit different properties depending on their self-assembly. While they are often associated with neurodegenerative diseases, functional amyl...
pubs.acs.org
Want to know about #IDPs? Why not hear from @rohitpappu68.bsky.social in his typical éloquence royale?
WebsEdge Science@websedgescience.bsky.social · last yr.For our first scientific session spotlight we are "Peeking away from the lampost" with Dr. Rohit Pappu as he joins us to discuss intrinsically disordered proteins. @rohitpappu68.bsky.social @biophysicalsoc.bsky.social #bps2025 youtu.be/pAP2lBWBiGU
Oh am sure every $ spent on $750b military is legit… saving $12b by killing science and bright minds is worth it.. grants.nih.gov/grants/guide...
NOT-OD-25-068: Supplemental Guidance to the 2024 NIH Grants Policy Statement: Indirect Cost Rates
NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Supplemental Guidance to the 2024 NIH Grants Policy Statement: Indirect Cost Rates NOT-OD-25-068. OD
grants.nih.gov
Wishing you all a peaceful, healthy, and a prosperous 2025!!
It was fantastic and humbling to receive a personal email from @J_A_C_S, the editor-in-chief, congratulating us on this work. Malay_Moldal and others deserve all the credit.👏
rangachari lab (vijay)@rangacharilab.bsky.social · 2y agoSharing our latest paper in the Journal of the American Chemical Society (JACS). We show that disulfide bond cross-links can reversibly tune the properties of #biomolecularcondensates to modulate their percolation behavior. pubs.acs.org/doi/10.1021/...
NEW SOCIETY ALERT! "International Society for Proteinopathies" is a group focused on pathomechanisms of protein-misfolding diseases. If you are interested in protein aggregation and phase transitions, this is for you. Please come on board with us.. www.proteinopathies.org
HOME | proteinopathies.org
proteinopathies.org
A significant discovery elegantly demonstrated... www.nature.com/articles/s41...
Stereochemistry in the disorder–order continuum of protein interactions - Nature
Studies on protein–protein interactions using proteins containing d- or l-amino acids show that stereoselectivity of binding varies with the degree of disorder within the complex.
nature.com
Check out our chapter on "Amyloid Polymorphism" in the book "The Three Functional States of Proteins." www.sciencedirect.com/science/arti...
Structural polymorphism in amyloids—states within proteins’ solid-state
Proteins are functionally diverse molecules that exist in a plethora of conformations and structures or as disordered ensembles, depending on their pr…
sciencedirect.com
We strongly suggest that academic publishers and other platforms that host research rapidly implement a Share to Bluesky button for their articles. Here's how: docs.bsky.app/docs/advance... #AcademicSky #HigherEd #Altmetrics
Action Intent Links | Bluesky
Authors, websites, and apps can use action intent links to implement "Share on Bluesky" buttons, or similar in-app actions. Logged-in users will be directed to the corresponding action view in the Blu...
docs.bsky.app
Biomolecular condensate starter pack! Trying to compile & to bring together biomolecular condensate enthusiasts & critics! Please join this non-exhaustive (sorry!) collection & just ping me for addition. #condensates, #phaseseparation, #granules, #IDPs go.bsky.app/NFqmffa
BONUS! If IDPs are your jam, check out an ever-expanding starter pack! go.bsky.app/J23B51L
Sharing our latest paper in the Journal of the American Chemical Society (JACS). We show that disulfide bond cross-links can reversibly tune the properties of #biomolecularcondensates to modulate their percolation behavior. pubs.acs.org/doi/10.1021/...
Reversible Disulfide Bond Cross-Links as Tunable Levers of Phase Separation in Designer Biomolecular Condensates
Biomolecular condensates (BCs) are membraneless hubs enriched with proteins and nucleic acids that have emerged as important players in many cellular functions. Uncovering the sequence determinants of...
pubs.acs.org
When the tweets are gone, it's time to ❌ the X and flutter to the Bluesky 🦋...
