Two-spotted scoliid wasp on mountain mint. Very skittish species, but the mint has tamed them! Such beautiful animals #bugsky

Latest from @arnaudkr.bsky.social on TF cooperation at enhancers, liked the combination of single-molecule footprinting at ectopic vs endogenous loci in mESCs. Curious if the cumulative activation frequency model holds for other less proliferative/plastic cell types? www.nature.com/articles/s41...

Cumulative transcription factor binding and p300-mediated histone acetylation drive enhancer activation frequency - Nature Genetics

This study uses single-molecule footprinting to quantify chromatin accessibility at enhancers and promoters in mouse embryonic stem cells and to dissect the contributions of transcription factor bindi...

nature.com

Excited to share our paper, now out in @jcb.org! 🎉 Co-led with @georgegalea.bsky.social at embl.org, we uncover a new layer of spatiotemporal regulation of the #DNADamageResponse between the Golgi and the nucleus, revealing an active role of the Golgi in #DNArepair. doi.org/10.1083/jcb.... 📷by me ❤️

流れ星つかまえたよ💫 Caught a little shooting star!

Happy to share the final version of our study on the evolution of chromatin states across eukaryotes, out today in @natgenet.nature.com Led by @crisnava.bsky.social and @seanamontgomery.bsky.social www.nature.com/articles/s41... Some highlights below

Diversity and evolution of chromatin regulatory states across eukaryotes - Nature Genetics

This study introduces iChIP2, a low-input chromatin immunoprecipitation followed by sequencing method that profiles histone post-translational modifications (hPTMs) simultaneously across diverse eukar...

nature.com

A resource of human RNA-protein associations is produced using a sequencing-based method go.nature.com/4gmf1Ii rdcu.be/fxFn1

Genome-wide mapping of RNA-protein associations through sequencing - Nature Biotechnology

A resource of human RNA-protein associations is produced using a sequencing-based method.

go.nature.com

Why do intrinsically disordered proteins behave so weirdly during SDS-PAGE? This is the question we aim to answer in our recent paper: onlinelibrary.wiley.com/doi/10.1002/...

Sequence determinants of the hypomobility of intrinsically disordered proteins in <fc>SDS</fc>‐<fc>PAGE</fc>

Proteins with intrinsically disordered regions (IDRs) migrate at a higher apparent molecular weight in sodium dodecyl sulfate (SDS)-polyacrylamide gel electrophoresis, complicating their analysis and...

onlinelibrary.wiley.com

🚀 New preprint 🥳 Fantastic work by our recent PhD graduate Daan ! How are mRNPs remodeled as they exit the nucleus? We identify PAIP1 as a factor that promotes exchange of the nuclear poly(A)-binding protein PABPN1 for cytoplasmic PABPC1, coupling mRNA export to cytoplasmic mRNP maturation.

bioRxiv Molecular Biology@biorxiv-molbio.bsky.social · 3d ago

PAIP1 couples mRNA export to cytoplasmic mRNP remodeling and poly(A) homeostasis https://www.biorxiv.org/content/10.64898/2026.07.31.742013v1

New in @embojournal.org: Polo/PLK1 phosphorylation relieves Cnn autoinhibition to drive centrosome scaffold assembly. Human CDK5RAP2 appears to share the fly-like mechanism.

Polo/PLK1 phosphorylation relieves Centrosomin/Cnn autoinhibition to promote centrosome scaffold assembly - The EMBO Journal

Mitotic centrosome maturation requires Polo/PLK1-dependent expansion of the pericentriolar material (PCM). In Drosophila, Centrosomin (Cnn) assembles a scaffold around mitotic centrioles through inter...

link.springer.com

Riboseek is a fast RNA/DNA search. More sensitive than nhmmer at 250x speed. Structure-aware realignment produces MSAs approaching rMSA quality. Plus 1.7M precomputed RNA MSAs, and an API to search your own 📄 www.biorxiv.org/content/10.6... 💾 github.com/steineggerla... 🌐 search.foldseek.com/riboseek

砂に潜るミミイカは何度みてもかわいい🦑

Happy RNA day!

Japan has now joined Horizon Europe. Japan’s researchers can now partner with teams across the EU. Together, we will advance global research in health, digital technologies, and climate neutrality ↓ link.europa.eu/YP7MtB

HOW IS THIS SKIPPER SO CUTE?! It’s like an anime character with those big eyes. And you can see the proboscis! (Grass Skipper) #invertebrates #BugSky 🌿

Get your calendars, because the new 2027 EMBL Annual Poster has arrived: s.embl.org/2027-poster Whether you'd like to enhance your skills in a practical course or engage with the latest research at one of our conferences, we've got you covered. See you at EMBL in 2027! 🙌 #LifeSciences #EMBL

Our study published today @science.org shows that X-chromosome inactivation (XCI) attracts L1 mutations to the human X chromosome: doi.org/10.1126/scie... With outstanding Perspective from @aurelien-doucet.bsky.social & @retrogenomics.bsky.social: doi.org/10.1126/scie...

Why is the X chromosome rich in L1 mobile elements? @science.org X-chromosome inactivation draws L1 mutagenesis to the human X chromosome | Science www.science.org/doi/10.1126/...

X-chromosome inactivation draws L1 mutagenesis to the human X chromosome

X-chromosome inactivation (XCI) enables gene dosage compensation in XX eutherians. Long interspersed element-1 (LINE-1 or L1) retrotransposons are unusually abundant on the human X chromosome and are ...

science.org

New from Fawzi + @mittalgrouptamu.bsky.social labs led by Busra Ozguney and Ryan Puterbaugh. Methionine oxidation in both helical conserved region and disordered regions of TDP-43 C-terminal domain decreases phase separation by perturbing different sets of contacts www.pnas.org/doi/10.1073/...

Methionine oxidation alters both helical assembly and disordered contacts in human TDP-43 C-terminal domain phase separation | PNAS

TAR DNA binding protein 43 (TDP-43), a key protein linked to ALS pathology, undergoes phase separation and forms functional assemblies via condensa...

pnas.org

EMBL researchers & colleagues show for the first time that the Golgi Complex plays an active role in regulating DNA repair. The research opens up new avenues for therapeutic interventions and drug development. Learn more: www.embl.org/news/science...

Today's @cosheidelberg.bsky.social seminar speaker is @chc-evobio.bsky.social talking on chromatin evolution #evochromo. Check out his really cool #preprint here: www.biorxiv.org/content/10.6...

ANNNNND introducing the amazing Katelyn @cookkate.bsky.social on bluesky... She finally made an account!

André Nadler@nadlerlab.bsky.social · last wk.

Lipids build the membranes of all cells, but identifying their precise functions is extremely challenging. Here’s our attempt to change that: How to find and understand lipid-protein interactions, by Katelyn Cook & company. www.biorxiv.org/content/10.6...

Lipids build the membranes of all cells, but identifying their precise functions is extremely challenging. Here’s our attempt to change that: How to find and understand lipid-protein interactions, by Katelyn Cook & company. www.biorxiv.org/content/10.6...

@georgegalea.bsky.social, @kuodyte.bsky.social, Pepperkok et al. reveal that RAD51C is anchored at the #Golgi by Giantin until DNA damage triggers ATM-dependent release & nuclear import, establishing the Golgi as a spatiotemporal regulator of nuclear #DNArepair rupress.org/jcb/article/...

Jim Shorter and his postdoc Miriam wrote a beautiful preview about our most recent paper on mRNAs preventing misfolding of IDR-containing proteins. UTR-ly unexpected: RNA chaperones tame intrinsically disordered proteins: Cell www.cell.com/cell/fulltex...

UTR-ly unexpected: RNA chaperones tame intrinsically disordered proteins

How do cells ensure that complex, multidomain proteins fold correctly? Luo et al. reveal a self-contained solution. The 3′UTR of an mRNA co-translationally chaperones the protein it encodes, preventin...

cell.com

Excited to see this project finally come together 🥳 I used the timing of nucleolar assembly at the 8-cell stage as an assay for concentration-dependent phase separation (doi.org/10.1016/j.cu...), but could never explain why they don't appear at the 4-cell stage. Now we know!! 🤓

GW Gant Luxton@gwgl.bsky.social · 2w ago

The nucleolus is the largest condensate in the nucleus and the site where ribosomes are built. It has no membrane. It assembles by phase separation, components demixing from the nucleoplasm into a droplet. So what decides when it forms? 🧵🪱💧 www.biorxiv.org/content/10.6...

The nucleolus is the largest condensate in the nucleus and the site where ribosomes are built. It has no membrane. It assembles by phase separation, components demixing from the nucleoplasm into a droplet. So what decides when it forms? 🧵🪱💧 www.biorxiv.org/content/10.6...

Thrilled to share that a big piece of my thesis here in the Starr–Luxton is now out in Science Advances! We discovered that the cytoplasm of living animal tissues is extremely crowded and constrained, maintained by ribosomes and the giant KASH protein ANC-1. www.science.org/doi/10.1126/...

Giant KASH proteins and ribosomes establish distinct cytoplasmic biophysical properties in vivo

Living tissues maintain unique intracellular biophysical properties under the control of cytoplasmic constraints and crowding.

science.org

We have a new paper out today from superstar Nora Herzog! A virus that fluidizes the nucleus to enable replication! Check it out here: lnkd.in/e-xV8acK This was an amazing collaboration with Ian Mohr and Angus Wilson

We are ready to welcome you to the FASEB Lipid Droplet Conference in beautiful Scottsdale, Arizona! #LipidSRC

Today’s @cosheidelberg.bsky.social seminar speaker is Andreas Meyer from UniBonn talking on #glutathione biology