Beautiful imaging of Killifish!

Phil Abitua@ohnolog.bsky.social · 2mo ago

Annual killifish continue to surprise us: they make neutrophils before almost every other cell type, even before gastrulation. Neutrophils usually arise from the lateral plate mesoderm (forming in cyan), but in killifish they are already patrolling around the embryo in gold. tinyurl.com/killiphil

Now at Princeton, @clairebedbrook.bsky.social and @ravi-nath.bsky.social led a study during their time as postdocs at Stanford that mapped the full arc of aging in individual vertebrates for the first time, finding that activity levels in young adults may serve as an early predictor of longevity.

Daily movement and sleep patterns can predict lifespan with striking accuracy

Some fish, it turns out, are morning people. They swim hard during daylight, sleep mostly at night, and tend to live longer.

yahoo.com

ICYMI 🧪

Claire Bedbrook@clairebedbrook.bsky.social · 6mo ago

Aging may feel gradual… but what if it’s not? In our recent paper, we tracked fish continuously from puberty until death. This gave us a unique view of how aging unfolds across the adult lifespan. 🧵

Youthful antics predict lifespan? Using machine learning & continuous recordings of #killifish behavior from adolescence until death, @brunetlab.bsky.social & @deisseroth.bsky.social find early-life behavior predicted future lifespan! Now published @science.org: www.science.org/doi/10.1126/... 🧪 1/2

Great work from Claire, Ravi, and the whole team– the initial lifelong continuous screen of behaving vertebrates provided a wealth of ideas on progression/staging of brain function across lifespan. Behavior is unmatched as a noninvasive quantitative readout of brain function (and, one that matters).

Zebrafish Rock!@zebrafishrock.bsky.social · 6mo ago

Youthful antics predict lifespan? Using machine learning & continuous recordings of #killifish behavior from adolescence until death, @brunetlab.bsky.social & @deisseroth.bsky.social find early-life behavior predicted future lifespan! Now published @science.org: www.science.org/doi/10.1126/... 🧪 1/2

Lifelong behavioral screen reveals an architecture of vertebrate aging | Science Was a wonderful collaboration with @clairebedbrook.bsky.social, Libby Zhang, Scott Linderman, @brunetlab.bsky.social & @deisseroth.bsky.social www.science.org/doi/10.1126/...

Lifelong behavioral screen reveals an architecture of vertebrate aging

Mapping behavior of individual vertebrate animals across lifespan could provide an unprecedented view into the lifelong process of aging. We created a platform for high-resolution continuous behaviora...

science.org