🚀 My first Cryo-EM structures are OUT on the PDB! 🎉Super excited about this milestone as PhD, it’s been a journey, and I’m grateful to finally have these as my first Cryo-EM structures! 🙌 🔁Thank you for sharing!❤️ Read @daaninthelab.bsky.social et. al.: www.science.org/doi/10.1126/... ⬇️ 2nd video

📢 Ready for this? A new way to think about Gene Regulation! 🚨A new coregulator complex, Zincore, acts as a "MOLECULAR GRIP", stabilizing TFs at DNA binding sites across the genome!🧬 💪Proud to be part of this work led by @daaninthelab.bsky.social Read more: science.org/doi/10.1126/science.adv2861

In today’s publication in Science we introduce Zincore: a novel protein of QRICH1 and SEPHS1 and functions as a transcriptional coregulator dedicated to zinc finger transcription factors. Here’s how we found it: 🧵 www.science.org/doi/10.1126/... 1/11

Zincore, an atypical coregulator, binds zinc finger transcription factors to control gene expression

Zinc finger proteins (ZNFs) are the largest family of transcription factors, yet how they activate gene expression remains unclear. In this study, we identified Zincore, a protein complex consisting o...

science.org

I think there is still much to learn about SRBD1, not only in mitosis but also regarding other potential functions. Its similarity to Spt6/SUPT6H continues to intrigue me 🤔

Cell Reports@cp-cellreports.bsky.social · last yr.

SRBD1, a highly conserved gene required for chromosome individualization

⚠️Don't forget! You have FREE alternatives! 🔖Reminder that @niaidnews.bsky.social offers 2000+ scientific and biomedical high-quality icons for free use! Check their full catalog: bioart.niaid.nih.gov 📢And if that’s not enough, you also have SciDraw and Bioicons! Comment if you want the websites.

I think there is still much to learn about SRBD1, not only in mitosis but also regarding other potential functions. Its similarity to Spt6/SUPT6H continues to intrigue me 🤔

Cell Reports@cp-cellreports.bsky.social · last yr.

SRBD1, a highly conserved gene required for chromosome individualization

📢 Excited to announce that our Opinion paper on GPI-anchored proteins is now Published! 🎉 👀 If you're working in this field, be sure to check out our paper — we've highlighted some truly outstanding questions on the topic! ⚠️ www.cell.com/trends/cell-...

🚨 New strategy against colorectal cancer! Dual GSK-3 & BCL-XL inhibition kills APC-mutant cells in organoid models, tipping the balance towards healthy cells—a promising way to halt early tumor growth 💪🧪 ➡️Read more: www.nature.com/articles/s41...

GSK-3 and BCL-XL inhibition mitigates the competitive advantage of APC-mutant colorectal cancer cells - Oncogenesis

Oncogenesis - GSK-3 and BCL-XL inhibition mitigates the competitive advantage of APC-mutant colorectal cancer cells

nature.com

👀 Just updated my Google Scholar and... can’t believe one of my papers reached 100 citations! 🚀 💪🏼 It might not seem like much, but as a PhD student, it feels like a big achievement. ❤️ To all fellow PhDs, keep going, stay strong, and celebrate every milestone!🔁 Read it: www.jbc.org/article/S002...

🚨New Article Out!! 📢 In our latest work, we propose a Three-Point Lock binding mode for ATX inhibitors 🔒 🚀 This approach may represent the final piece in the puzzle of known binding mode types — and could have therapeutic relevance ♥️ Thanks for your support Read more here: doi.org/10.1016/j.bm...

🚀 My first Cryo-EM structures are OUT on the PDB! 🎉Super excited about this milestone as PhD, it’s been a journey, and I’m grateful to finally have these as my first Cryo-EM structures! 🙌 🔁Thank you for sharing!❤️ Read @daaninthelab.bsky.social et. al.: www.science.org/doi/10.1126/... ⬇️ 2nd video

📢 Ready for this? A new way to think about Gene Regulation! 🚨A new coregulator complex, Zincore, acts as a "MOLECULAR GRIP", stabilizing TFs at DNA binding sites across the genome!🧬 💪Proud to be part of this work led by @daaninthelab.bsky.social Read more: science.org/doi/10.1126/science.adv2861

🚀 Excited about our pre-print: AlphaBridge: A User-Friendly Tool for Interpreting Protein Predictions Whether you're an expert or just new to the field of Protein Prediction, AlphaBridge is the way to go! 🔁Try it and share your thoughts! 📜 Article: www.biorxiv.org/content/10.1...

📢 Make your work FASTER and EASIER! Use AlphaBridge to analyze your AlphaFold results and receive a clear, easy-to-understand output—even for non-experts. ➡️ Let AlphaBridge help you accelerate your workflow! ❤️ Share and try it here: alpha-bridge.eu 👀Read more: www.biorxiv.org/content/10.1...

AlphaFold can predict protein, DNA, or RNA complexes.. BUT is it easy to determine the reliable interactions?🤔 ➡️ AlphaBridge will identify the most confident interactions, making your analysis easier! 🌐Try it here: alpha-bridge.eu 👀Read more: www.biorxiv.org/content/10.1...

@science.org Zincore-coregulator dedicated to zinc🖐️ TFs essential in development www.science.org/doi/10.1126/... @rborza.bsky.social @sgregoricchio.bsky.social @amazouzi.bsky.social @zwartlab.bsky.social @lindersimon.bsky.social @tassosperrakis.bsky.social @thijnbrummel.bsky.social + al.

Danielle Bianchi@daaninthelab.bsky.social · last yr.

In today’s publication in Science we introduce Zincore: a novel protein of QRICH1 and SEPHS1 and functions as a transcriptional coregulator dedicated to zinc finger transcription factors. Here’s how we found it: 🧵 www.science.org/doi/10.1126/... 1/11

🚨New Article Out!! 📢 In our latest work, we propose a Three-Point Lock binding mode for ATX inhibitors 🔒 🚀 This approach may represent the final piece in the puzzle of known binding mode types — and could have therapeutic relevance ♥️ Thanks for your support Read more here: doi.org/10.1016/j.bm...

⚠️THREAD OF ALL SCIENCE-RELATED STARTER PACKS! ⚠️ 🔄Share to help people finding its topic/field - STRUCTURAL BIOLOGY Structural Biology 1: bsky.app/starter-pack... Structural Biology 2: bsky.app/starter-pack... Crystallography: bsky.app/starter-pack... Synchrotron&CryoEM: bsky.app/starter-pack...

I created this Starter Pack for PhDs and Postdocs in Structural Biology to help connect with colleagues who share similar interests and concerns in the field. Feel free to recommend people or yourself! I'll be adding people 💪🏼😁 bsky.app/starter-pack...

📢 Excited to announce that our Opinion paper on GPI-anchored proteins is now Published! 🎉 👀 If you're working in this field, be sure to check out our paper — we've highlighted some truly outstanding questions on the topic! ⚠️ www.cell.com/trends/cell-...

🎄✨ Early Holiday Update from AlphaBridge! ✨🎄 Exciting new features: 🔬 Confidence Filters: Identify more/less confident interfaces. 🔬 Scoring System: New scores for overall structure & individual interfaces. Try it here!! alpha-bridge.eu 🎁 📄 Preprint: www.biorxiv.org/content/10.1...

Surely you have been using AlphaFold3 for your research project? If so, have you considered #AlphaBridge to analyze the output for macromolecule complexes prediction? Web server: alpha-bridge.eu Preprint: www.biorxiv.org/content/10.1... New features coming soon!

📢 Make your work FASTER and EASIER! Use AlphaBridge to analyze your AlphaFold results and receive a clear, easy-to-understand output—even for non-experts. ➡️ Let AlphaBridge help you accelerate your workflow! ❤️ Share and try it here: alpha-bridge.eu 👀Read more: www.biorxiv.org/content/10.1...

📢 Bluesky is emerging as the New Platform for Academia, but what's missing? 📊 Altmetric integration to track attention for articles 🔄 Share and ♥️ Like if you agree! 🙏 @altmetric.com please tell us it’s going to happen!

Just got some nice positional averaging inside of #MolecularNodes. Smooth out trajectories across frames when visualising, add subframes, also takes into account periodic boundary crossing so you don't have zooming lipids #b3d #GeometryNodes #GlycoTime #SciArt

🚨 If you haven’t seen it yet… 📢 The NIH BioArt Source provides a library of FREE professionally designed illustrations and icons, available for anyone to use. They can be Downloaded in High Definition. Check it out at bioart.niaid.nih.gov

I’ve already seen plenty of images here on Bluesky using #MolecularNodes, so now it’s time to share my first one! 🤔 Which one do you prefer: with or without surface? ⚠️ Follow @bradyajohnston.bsky.social to stay updated on MolecularNodes!