“GSK-3 and BCL-XL inhibition mitigates the competitive advantage of APC-mutant colorectal cancer cells” 🔷 Jan Paul Medema latest research is now available to read in #Oncogenesis. ▶️ Read the full open access article here: www.nature.com/articles/s41...

🚨 New strategy against colorectal cancer! Dual GSK-3 & BCL-XL inhibition kills APC-mutant cells in organoid models, tipping the balance towards healthy cells—a promising way to halt early tumor growth 💪🧪 ➡️Read more: www.nature.com/articles/s41...

GSK-3 and BCL-XL inhibition mitigates the competitive advantage of APC-mutant colorectal cancer cells - Oncogenesis

Oncogenesis - GSK-3 and BCL-XL inhibition mitigates the competitive advantage of APC-mutant colorectal cancer cells

nature.com

👀 Just updated my Google Scholar and... can’t believe one of my papers reached 100 citations! 🚀 💪🏼 It might not seem like much, but as a PhD student, it feels like a big achievement. ❤️ To all fellow PhDs, keep going, stay strong, and celebrate every milestone!🔁 Read it: www.jbc.org/article/S002...

🚨 Our team just released a reproducible Docker pipeline for RNAseq assembly and annotation designed for nonmodel organisms! We're using it to explore how bats manage viral infections, but it's built for broad utility in wildlife transcriptomics. @viralemergence.org www.biorxiv.org/content/10.1...

TATAT: a containerized software for generating annotated coding transcriptomes from raw RNA-seq data

Motivation: Many transcriptome creation workflows are not standardized, are difficult to install or share, prone to breaking as dependencies update or cease to be maintained and are resource intensive...

biorxiv.org

SLC7A11 protects amoeboid-disseminating cancer cells from oxidative stress: Cell Reports www.cell.com/cell-reports...

SLC7A11 protects amoeboid-disseminating cancer cells from oxidative stress

Graziani et al. show that SLC7A11 increases during melanoma disease progression. SLC7A11 promotes Myosin II-driven amoeboid invasive behavior while shielding amoeboid cancer cells from oxidative stres...

cell.com

🚨 If you haven’t seen it yet… 📢 The NIH BioArt Source provides a library of FREE professionally designed illustrations and icons, available for anyone to use. They can be Downloaded in High Definition. Check it out at bioart.niaid.nih.gov

📢 Ready for this? A new way to think about Gene Regulation! 🚨A new coregulator complex, Zincore, acts as a "MOLECULAR GRIP", stabilizing TFs at DNA binding sites across the genome!🧬 💪Proud to be part of this work led by @daaninthelab.bsky.social Read more: science.org/doi/10.1126/science.adv2861

🚨 New strategy against colorectal cancer! Dual GSK-3 & BCL-XL inhibition kills APC-mutant cells in organoid models, tipping the balance towards healthy cells—a promising way to halt early tumor growth 💪🧪 ➡️Read more: www.nature.com/articles/s41...

GSK-3 and BCL-XL inhibition mitigates the competitive advantage of APC-mutant colorectal cancer cells - Oncogenesis

Oncogenesis - GSK-3 and BCL-XL inhibition mitigates the competitive advantage of APC-mutant colorectal cancer cells

nature.com

In today’s publication in Science we introduce Zincore: a novel protein of QRICH1 and SEPHS1 and functions as a transcriptional coregulator dedicated to zinc finger transcription factors. Here’s how we found it: 🧵 www.science.org/doi/10.1126/... 1/11

Zincore, an atypical coregulator, binds zinc finger transcription factors to control gene expression

Zinc finger proteins (ZNFs) are the largest family of transcription factors, yet how they activate gene expression remains unclear. In this study, we identified Zincore, a protein complex consisting o...

science.org

🎨 In case anyone need… The NIH BioArt Source is an awesome library of *free* professionally drawn illustrations for scientific presentations or figures. Downloadable in HD. Thank you NIH for this invaluable tool 🙏! Check it out 👇 bioart.niaid.nih.gov

I’ve already seen plenty of images here on Bluesky using #MolecularNodes, so now it’s time to share my first one! 🤔 Which one do you prefer: with or without surface? ⚠️ Follow @bradyajohnston.bsky.social to stay updated on MolecularNodes!