Elamipretide: A Review of Its Structure, Mechanism of Action, and Therapeutic Potential

Mitochondria serve an essential metabolic and energetic role in cellular activity, and their dysfunction has been implicated in a wide range of disorders, including cardiovascular conditions, neurodeg...

pmc.ncbi.nlm.nih.gov

Gut microbiota can predict risk of type 2 diabetes years before it develops

The presence of certain bacteria in the gut microbiota, and fluctuations in a person's metabolism, can be seen in people who go on to develop type 2 diabetes years later. This has been shown in a larg...

medicalxpress.com

Tauroursodeoxycholic Acid May Improve Liver and Muscle but Not Adipose Tissue Insulin Sensitivity in Obese Men and Women

Insulin resistance is commonly associated with obesity. Studies conducted in obese mouse models found that endoplasmic reticulum (ER) stress contributes to insulin resistance, and treatment with tauro...

pmc.ncbi.nlm.nih.gov

Whole organ 3D imaging reveals remaining insulin producing cells in type 1 diabetes

Researchers at Umeå University have conducted a unique three-dimensional mapping of an entire human pancreas. The study shows that insulin-producing cells can remain long after the onset of type 1 diabetes – a finding that suggests the disea...

eurekalert.org

Karius Spectrum - Advanced Infectious Disease Blood Test | Karius

Karius Spectrum is an infectious disease blood test that uses next-generation sequencing to detect over 1,000 pathogens with speed and accuracy.

kariusdx.com

Analysis of SARS-CoV-2 known and novel subgenomic mRNAs in cell culture, animal model, and clinical samples using LeTRS, a bioinformatic tool to identify unique sequence identifiers

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has a complex strategy for the transcription of viral subgenomic mRNAs (sgmRNAs), which are targets for nucleic acid diagnostics. Each of t...

pmc.ncbi.nlm.nih.gov

Autoantibody landscapes in neurological Long COVID and post-COVID cognitive impairment show heterogeneity without a shared disease signature

Background Neurological Long COVID (n-LC) includes persistent cognitive and autonomic symptoms after SARS-CoV-2 infection. Prior studies of post-COVID conditions have described diverse humoral autorea...

medrxiv.org

Invasive mosquitoes and brain-swelling virus detected in B.C.’s Sea-to-Sky region

Health officials in British Columbia say invasive mosquitoes and a virus that can cause brain swelling in humans have been detected in the Sea-to-Sky region north of Vancouver, after an investigation triggered by a cluster of childhood encephalitis cases.

cheknews.ca

A putative xanthine dehydrogenase is critical for Borrelia burgdorferi survival in ticks and mice

Borrelia burgdorferi is a pathogenic bacterium and the causative agent of Lyme disease. It is exposed to reactive oxygen species (ROS) in both the vertebrate and tick hosts. While some mechanisms by w...

pmc.ncbi.nlm.nih.gov

Epstein-Barr Virus Antibodies to Differentiate Multiple Sclerosis From Other Neuroinflammatory Diseases - PubMed

Results of this case-control study reveal that persistent high-level EBNA-1 peptide antibody titers may serve as a reliable biomarker for differentiating MS from MOGAD, and NMOSD.

pubmed.ncbi.nlm.nih.gov

Galaxy Dx: Lyme Borrelia Detection Trusted 25+ Years

Lyme Borrelia detection at Galaxy Dx improves diagnosis with trusted, science-backed testing solutions.

galaxydx.com

Thiamine deficiency leads to reduced nitric oxide production and vascular dysfunction in rats

Thiamine deficiency is a condition that is known to cause damage to the nervous and cardiovascular systems because it interferes with cellular metabol…

sciencedirect.com

Behçet's Disease with Severe Autonomic Disorders Developing after Herpes Zoster

A 58-year-old Japanese woman with herpes zoster developed Behçet's disease (BD) with symptoms including orthostatic intolerance as an autonomic disorder. Multiple immune-suppressive therapies and a β-...

pmc.ncbi.nlm.nih.gov