Access to four-membered cyclic sulfinamides by energy transfer catalysis

Synthetic transformations that advance through excited states proceed by unconventional mechanistic pathways and deliver products not accessible using ground-state chemistry. The breadth of these synt...

science.org

Access to four-membered cyclic sulfinamides by energy transfer catalysis

Synthetic transformations that advance through excited states proceed by unconventional mechanistic pathways and deliver products not accessible using ground-state chemistry. The breadth of these synt...

science.org

Desulfinative Cross-Coupling as a Method to Overcome Problematic Suzuki–Miyaura Reactions of Pharmaceutically Relevant Heteroaromatic Boronates

The well documented difficulties associated with direct (hetero)arylation of aza-aromatics (e.g., azines) at the α-position to nitrogen led to a collaborative project between the Willis group at Oxfor...

pubs.acs.org

A modular synthesis of azetidines from reactive triplet imine intermediates using an intermolecular aza Paternò–Büchi reaction - Nature Catalysis

Azetidines are four-membered saturated N-heterocycles that are of interest in drug discovery and medicinal chemistry. Here the authors report how sulfamoyl fluoride substituents tune the reactivity of...

nature.com

Iron-Catalyzed Decarboxylative Sulfinylation of Alkyl Carboxylic Acids

Sulfinamides, sulfonamides, and sulfonimidamides are valuable motifs in medicinal chemistry, yet methods to synthesize alkyl variants from simple, readily available feedstocks remain scarce. In this report, we detail the synthesis of these three distinct sulfur functional groups, using readily available and structurally diverse alkyl carboxylic acids as the starting materials. The method harnesses alkyl radical generation from carboxylic acids using commercial iron salts and visible light irradiation, in combination with commercial sulfinylamine reagents, to deliver alkyl sulfinamide products. The method is operationally simple and scalable, exhibits broad functional group tolerance, and is translatable to continuous-flow synthesis. Furthermore, it facilitates late-stage diversification of complex molecules, highlighting its potential utility in medicinal chemistry applications.

pubs.acs.org

Iron-Catalyzed Decarboxylative Sulfinylation of Alkyl Carboxylic Acids

Sulfinamides, sulfonamides, and sulfonimidamides are valuable motifs in medicinal chemistry, yet methods to synthesize alkyl variants from simple, readily available feedstocks remain scarce. In this report, we detail the synthesis of these three distinct sulfur functional groups, using readily available and structurally diverse alkyl carboxylic acids as the starting materials. The method harnesses alkyl radical generation from carboxylic acids using commercial iron salts and visible light irradiation, in combination with commercial sulfinylamine reagents, to deliver alkyl sulfinamide products. The method is operationally simple and scalable, exhibits broad functional group tolerance, and is translatable to continuous-flow synthesis. Furthermore, it facilitates late-stage diversification of complex molecules, highlighting its potential utility in medicinal chemistry applications.

pubs.acs.org

2025 Chemical Science HOT Article Collection Home

rsc.li

Chem25@Bath | 25 Years of Discovery, Innovation & Community in 1 South

Chem25: Marking 25 Years of Innovation in the 1 South Chemistry Building, University of Bath

chem25.co.uk

Synthesis and functionalization of vinyl sulfonimidamides and their potential as electrophilic warheads

Covalent inhibitor design is dominated by the use of electrophilic acrylamide warheads. One limitation of acrylamides is that there are limited opportunities to modify their electrophilicity, and henc...

pubs.rsc.org

Meet the Winners of the 2025 Organic Letters Outstanding Publication of the Year Award | ACS Publications Chemistry Blog

Get to know the 2025 recipients, read their winning article, and learn about their plans for building upon their existing research.

axial.acs.org

From compressed yeast to cream cheese and cornflakes: one man’s search for the world’s greatest ...

Barry Enderwick has recreated more than 700 sandwich recipes from history, dating from 200BC to the present day. What has he learned – and crucially – which are the tastiest?

theguardian.com